NAD+ precursors, senolytics, and cellular health compounds that target aging pathways and promote vitality.
31 itemsA focused look at fasting‑mimicking diets and autophagy: what human trials and animal studies suggest, how nutrient‑sensing pathways are involved, and where evidence is still emerging.
Homocysteine is a practical window into methylation. Learn what your level means, how B vitamins, genetics, and lifestyle affect it, and where food-first strategies fit—without the hype.
How CoQ10 supports cellular energy through mitochondrial electron transport, plus evidence on aging, statins, heart failure (Q-SYMBIO), migraines, fertility, forms, and PQQ.
Can astragalus (Huang Qi) or TA-65 meaningfully support telomere health? A concise, evidence-based review of telomerase activation, human data, safety, and where traditional and modern perspectives meet.
A focused look at how caloric restriction and rapamycin converge on the mTOR pathway, what ITP mouse studies show, early human and dog trial signals, risks, and natural mTOR modulators.
What MRI and DTI studies suggest about meditation and brain structure, from cortical thickness and hippocampal volume to amygdala changes, plus outcomes and caveats.
A focused, evidence-based look at turkey tail mushroom’s PSK/PSP beta-glucans, how they may modulate immunity, what clinical research suggests, why extraction matters, and how this aligns with TCM.
Research-based look at when autophagy may start during fasting, what triggers it, and how time-restricted eating, alternate-day fasting, fasting-mimicking diets, and Ramadan relate to autophagy.
A focused, evidence-based guide to homocysteine as a practical marker of B‑vitamin status and methylation, what affects it, and food-first strategies.
A focused, evidence-based look at how CoQ10 powers mitochondrial electron transport and cellular energy, with aging, statin, bioavailability, and PQQ context.
A focused look at how chronic stress relates to telomere length, what mechanisms and trials suggest, and why telomere testing is not a stress gauge.
Resveratrol’s mixed human results may stem from low bioavailability and metabolite complexity. This focused review explains the sirtuin controversy, summarizes clinical evidence, and compares resveratrol with other polyphenols.
A focused review of what the NIA Interventions Testing Program (ITP) reveals about rapamycin’s lifespan effects, how it intersects with caloric restriction via mTOR, early dog and human data, risks, and natural modulators.
A focused, evidence-based look at turkey tail mushroom’s PSK/PSP and immunity—mechanisms, clinical adjunct data, extraction methods, and how TCM perspectives align with modern research.
Does time-restricted eating trigger autophagy? Research suggests TRE creates conditions that may activate cellular cleanup pathways linked to longevity, though direct human evidence remains limited.
MTHFR C677T is common and usually benign. Learn what it means for folate, homocysteine, and real-world health, plus practical, food-first steps grounded in evidence.
A focused, evidence-based look at how stress and mindfulness practices relate to telomere biology, what testing can (and can’t) tell you, and why oversimplified telomere claims fall short.
Resveratrol’s promise meets pharmacokinetics: how low bioavailability shapes human results, what sirtuin research really suggests, and which delivery strategies are emerging.
The ITP’s rapamycin results show strong lifespan extension in mice via mTORC1 inhibition. Here’s how that connects to caloric restriction, ongoing human and dog trials, risks, and natural mTOR modulators—and why excitement is tempered by caution.
A focused look at how meditation relates to cortical thickness on MRI — where changes appear, what meta-analyses show, and how practice style and dose may matter.
Does autophagy start at a specific hour of fasting? This evidence-based guide explains what animal and human studies suggest about fasting, timing, and real-world patterns like TRE, 5:2, ADF, fasting-mimicking diets, and Ramadan.
Human results for resveratrol are mixed, and bioavailability is a key reason. This focused review explains how metabolism, food matrix, and formulations shape exposure—and why that matters for interpreting clinical evidence.
A focused review of how CoQ10 underpins cellular energy, how aging and statins intersect with CoQ10 biology, and where clinical research signals potential benefits—plus forms and PQQ as a complement.
Does HIIT or steady endurance do more for telomere health? Research suggests both aerobic styles may support telomerase activity and telomere-protective mechanisms, while resistance-only effects are mixed. Here’s what randomized trials and reviews say.
BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids derived from a protective protein found in human gastric juice. It was first isolated by researchers studying the mechanisms behind the stomach's remarkable ability to heal itself despite constant exposure to hydrochloric acid and digestive enzymes. Animal studies have demonstrated accelerated healing of tendons, ligaments, muscles, nerves, and the gastrointestinal tract. The proposed mechanisms include upregulation of growth hormone receptors, promotion of angiogenesis (new blood vessel formation), modulation of the nitric oxide system, and interaction with the FAK-paxillin pathway involved in tissue repair. Despite promising preclinical data, human clinical trials remain limited. Most evidence comes from rodent models, and the peptide's regulatory status varies by country. It is not FDA-approved for any medical condition. Users in the biohacking and athletic recovery communities report benefits for joint injuries, gut healing, and tendon repair, but these remain anecdotal.
Hydrolyzed collagen protein fragments used to support skin elasticity, joint health, and connective tissue repair.
A rich source of EPA and DHA omega-3 fatty acids, commonly used to support cardiovascular health and reduce inflammation.
A hormone naturally produced by the pineal gland that regulates sleep-wake cycles, commonly supplemented for sleep disorders and jet lag.
Nicotinamide mononucleotide (NMN) is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in every living cell that participates in over 500 enzymatic reactions. NAD+ is essential for mitochondrial energy production, DNA repair via PARP enzymes, and activation of sirtuins — a family of seven proteins often called "longevity regulators." NAD+ levels decline significantly with age — by roughly 50% between ages 40 and 60 in some tissues. This decline is implicated in mitochondrial dysfunction, impaired DNA repair, metabolic disorders, and the broader phenotype of aging. NMN supplementation aims to restore NAD+ levels by providing the immediate biosynthetic precursor. Animal studies have demonstrated remarkable results: improved insulin sensitivity, enhanced mitochondrial function, increased exercise endurance, and extended healthspan in aged mice. The first long-term human clinical trial (2022) showed that 250mg NMN daily for 12 weeks increased blood NAD+ levels and improved muscle function in older men. However, the field is still young, and optimal dosing, long-term safety, and definitive anti-aging effects in humans remain under investigation.
Omega-3 fatty acids — specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) — are polyunsaturated fats that the human body cannot synthesize de novo. They must be obtained from dietary sources, primarily fatty fish (salmon, mackerel, sardines, anchovies), shellfish, and marine algae. EPA and DHA serve as structural components of cell membranes throughout the body, with particularly high concentrations in the brain (DHA comprises roughly 40% of polyunsaturated fatty acids in the brain) and retina. Beyond structural roles, they are precursors to specialized pro-resolving mediators (SPMs) — resolvins, protectins, and maresins — that actively resolve inflammation rather than simply suppressing it. The evidence base for omega-3 supplementation is extensive. Large-scale trials and meta-analyses support benefits for cardiovascular health (triglyceride reduction, modest blood pressure lowering), inflammatory conditions, mood disorders, and cognitive maintenance. The American Heart Association recommends at least two servings of fatty fish per week, and higher-dose EPA supplementation has been shown to reduce cardiovascular events in the REDUCE-IT trial.
Alzheimer’s disease (AD) and cardiovascular disease (CVD) are tightly linked along a brain–heart axis. They share many modifiable risk factors—hypertension, diabetes, dyslipidemia, obesity, smoking...
