NAD+ precursors, senolytics, and cellular health compounds that target aging pathways and promote vitality.
31 itemsDoes resveratrol truly activate sirtuins in humans? A concise, evidence-based look at the science, controversies, bioavailability, and how it compares with other polyphenols.
How long does fasting take to trigger autophagy? A focused, evidence-based look at timelines, mechanisms, and what human studies do—and don’t—show.
Homocysteine offers a practical window into methylation and B‑vitamin status. Learn what influences it, how food-first strategies help, and where forms like methylfolate may fit.
How CoQ10 powers mitochondrial ATP production, why levels change with age and statins, what clinical signals say about “energy,” how ubiquinol compares to ubiquinone for bioavailability, and where PQQ may complement CoQ10.
A focused, evidence-based review of how exercise relates to telomere biology, what trials and meta-analyses show, how mind–body movement may contribute, and why telomere testing has limits.
A focused look at the ITP rapamycin mouse studies—what they showed about mTOR and longevity, how they relate to caloric restriction, translation to humans and dogs, and why researchers remain cautiously optimistic.
A clear, evidence-based look at homocysteine as a methylation marker—what raises it, what it predicts, and how food-first strategies with B vitamins support healthy levels.
A focused, evidence-based look at MTHFR polymorphisms—what they change in methylation, how common they are, and what matters most (homocysteine and B vitamin status) versus hype.
Does endurance exercise influence telomere length? A focused, evidence-based look at HIIT and aerobic training, telomerase activity, mechanisms, caveats, and what it means for healthy aging.
A focused look at the NIA Interventions Testing Program’s findings on rapamycin, how it intersects with caloric restriction and mTOR, current human and dog trials, risks, and why researchers remain cautiously optimistic.
A focused review of rapamycin in the NIA Interventions Testing Program (ITP) and what the robust mouse data mean—mechanisms via mTOR, links to caloric restriction, early human and dog studies, and why researchers are cautiously optimistic.
Research-based look at how chronic psychological stress relates to telomere length, what mechanisms are involved, what interventions may help, and where the hype overreaches.
A focused look at rapamycin and the mTOR pathway in longevity: ITP mouse findings, how caloric restriction converges on mTOR, the status of human and dog trials, potential risks, and natural mTOR modulators—why the field is hopeful yet cautious.
A focused look at how long fasting may take to engage autophagy, summarizing animal data, human intermittent fasting trials, fasting-mimicking diets, and traditional fasts—highlighting what’s known and what remains uncertain.
Research-backed look at how mindfulness and stress reduction relate to telomere length, what mechanisms are plausible, and where claims outpace evidence.
Does resveratrol really activate sirtuins in humans? A focused review of the evidence—French Paradox origins, bioavailability challenges, mixed trials, and how it compares to EGCG, curcumin, and quercetin.
A focused look at the NIA Interventions Testing Program’s rapamycin findings in mice, how they align with mTOR and caloric restriction biology, and what this means—cautiously—for human longevity research.
Does time-restricted eating (TRE) trigger autophagy? A focused, evidence-based review of mechanisms, human trials, and how TRE compares with other fasting models.
A focused, evidence-based look at how chronic psychological stress relates to telomere length, what interventions may help, and what telomere testing can and cannot tell you.
A focused look at the Interventions Testing Program (ITP) mouse studies of rapamycin, how they link to mTOR and caloric restriction, and what they do—and don’t—imply for human longevity.
A focused look at fasting‑mimicking diets and autophagy: what human trials and animal studies suggest, how nutrient‑sensing pathways are involved, and where evidence is still emerging.
Homocysteine is a practical window into methylation. Learn what your level means, how B vitamins, genetics, and lifestyle affect it, and where food-first strategies fit—without the hype.
How CoQ10 supports cellular energy through mitochondrial electron transport, plus evidence on aging, statins, heart failure (Q-SYMBIO), migraines, fertility, forms, and PQQ.
Can astragalus (Huang Qi) or TA-65 meaningfully support telomere health? A concise, evidence-based review of telomerase activation, human data, safety, and where traditional and modern perspectives meet.
BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids derived from a protective protein found in human gastric juice. It was first isolated by researchers studying the mechanisms behind the stomach's remarkable ability to heal itself despite constant exposure to hydrochloric acid and digestive enzymes. Animal studies have demonstrated accelerated healing of tendons, ligaments, muscles, nerves, and the gastrointestinal tract. The proposed mechanisms include upregulation of growth hormone receptors, promotion of angiogenesis (new blood vessel formation), modulation of the nitric oxide system, and interaction with the FAK-paxillin pathway involved in tissue repair. Despite promising preclinical data, human clinical trials remain limited. Most evidence comes from rodent models, and the peptide's regulatory status varies by country. It is not FDA-approved for any medical condition. Users in the biohacking and athletic recovery communities report benefits for joint injuries, gut healing, and tendon repair, but these remain anecdotal.
Hydrolyzed collagen protein fragments used to support skin elasticity, joint health, and connective tissue repair.
A rich source of EPA and DHA omega-3 fatty acids, commonly used to support cardiovascular health and reduce inflammation.
A hormone naturally produced by the pineal gland that regulates sleep-wake cycles, commonly supplemented for sleep disorders and jet lag.
Nicotinamide mononucleotide (NMN) is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in every living cell that participates in over 500 enzymatic reactions. NAD+ is essential for mitochondrial energy production, DNA repair via PARP enzymes, and activation of sirtuins — a family of seven proteins often called "longevity regulators." NAD+ levels decline significantly with age — by roughly 50% between ages 40 and 60 in some tissues. This decline is implicated in mitochondrial dysfunction, impaired DNA repair, metabolic disorders, and the broader phenotype of aging. NMN supplementation aims to restore NAD+ levels by providing the immediate biosynthetic precursor. Animal studies have demonstrated remarkable results: improved insulin sensitivity, enhanced mitochondrial function, increased exercise endurance, and extended healthspan in aged mice. The first long-term human clinical trial (2022) showed that 250mg NMN daily for 12 weeks increased blood NAD+ levels and improved muscle function in older men. However, the field is still young, and optimal dosing, long-term safety, and definitive anti-aging effects in humans remain under investigation.
Omega-3 fatty acids — specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) — are polyunsaturated fats that the human body cannot synthesize de novo. They must be obtained from dietary sources, primarily fatty fish (salmon, mackerel, sardines, anchovies), shellfish, and marine algae. EPA and DHA serve as structural components of cell membranes throughout the body, with particularly high concentrations in the brain (DHA comprises roughly 40% of polyunsaturated fatty acids in the brain) and retina. Beyond structural roles, they are precursors to specialized pro-resolving mediators (SPMs) — resolvins, protectins, and maresins — that actively resolve inflammation rather than simply suppressing it. The evidence base for omega-3 supplementation is extensive. Large-scale trials and meta-analyses support benefits for cardiovascular health (triglyceride reduction, modest blood pressure lowering), inflammatory conditions, mood disorders, and cognitive maintenance. The American Heart Association recommends at least two servings of fatty fish per week, and higher-dose EPA supplementation has been shown to reduce cardiovascular events in the REDUCE-IT trial.
Alzheimer’s disease (AD) and cardiovascular disease (CVD) are tightly linked along a brain–heart axis. They share many modifiable risk factors—hypertension, diabetes, dyslipidemia, obesity, smoking...
