NAD+ precursors, senolytics, and cellular health compounds that target aging pathways and promote vitality.
23 itemsDoes autophagy start at a specific hour of fasting? This evidence-based guide explains what animal and human studies suggest about fasting, timing, and real-world patterns like TRE, 5:2, ADF, fasting-mimicking diets, and Ramadan.
Does HIIT or steady endurance do more for telomere health? Research suggests both aerobic styles may support telomerase activity and telomere-protective mechanisms, while resistance-only effects are mixed. Here’s what randomized trials and reviews say.
Human results for resveratrol are mixed, and bioavailability is a key reason. This focused review explains how metabolism, food matrix, and formulations shape exposure—and why that matters for interpreting clinical evidence.
A focused review of how CoQ10 underpins cellular energy, how aging and statins intersect with CoQ10 biology, and where clinical research signals potential benefits—plus forms and PQQ as a complement.
The ITP mouse studies put rapamycin and mTOR at the center of longevity science. Here’s what those data show, how they relate to caloric restriction, early human and dog trials, safety concerns, and why researchers are optimistic yet cautious.
A focused review of time-restricted eating and autophagy: what human trials show, how it compares with alternate-day and fasting-mimicking diets, and insights from Ramadan and traditional fasts.
mTOR and rapamycin are at the center of longevity research. Here’s what robust mouse studies, early human trials, and traditional practices suggest—along with the key risks and why scientists remain cautiously optimistic.
Neuroimaging and clinical trials suggest meditation may reshape attention and emotion circuits—supporting reductions in anxiety/depressive symptoms and echoing 2,500+ years of contemplative tradition.
A research-grounded review of CoQ10’s role in mitochondrial energy, aging, statin-related depletion, heart failure, migraines, fertility, and the ubiquinone vs ubiquinol debate—plus how PQQ may complement CoQ10.
Resveratrol helped spark the French Paradox era and the hunt for “longevity molecules.” Two decades later, evidence shows mixed human benefits, bioavailability hurdles, and nuanced sirtuin biology—while other polyphenols like EGCG, curcumin, and quercetin show more consistent effects on select health markers. A food-first, tradition-informed approach remains the most evidence-aligned path for healthy aging.
A balanced, evidence-based look at how lifestyle may influence telomeres, what telomerase activators like TA‑65 and astragalus can and can’t do, and what telomere testing really means for longevity.
CoQ10 powers mitochondrial energy production and may support healthy aging. This evidence-based guide reviews age-related decline, statin effects, heart failure (Q-SYMBIO), migraine prevention, fertility research, bioavailability of ubiquinone vs. ubiquinol, and PQQ as a complementary compound.
Autophagy, fasting, and longevity—what Nobel-winning cell biology, clinical trials, and traditional practices collectively suggest about healthspan, with evidence levels and practical context.
The most studied supplement in history does far more than build muscle. A deep dive into creatine for cognition, energy, and healthy aging.
Inside the science of nicotinamide mononucleotide, NAD+ precursors, and why researchers believe they may slow biological aging.
EPA vs. DHA ratios, oxidation concerns, triglyceride vs. ethyl ester forms — the definitive guide to choosing the right omega-3.
BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids derived from a protective protein found in human gastric juice. It was first isolated by researchers studying the mechanisms behind the stomach's remarkable ability to heal itself despite constant exposure to hydrochloric acid and digestive enzymes. Animal studies have demonstrated accelerated healing of tendons, ligaments, muscles, nerves, and the gastrointestinal tract. The proposed mechanisms include upregulation of growth hormone receptors, promotion of angiogenesis (new blood vessel formation), modulation of the nitric oxide system, and interaction with the FAK-paxillin pathway involved in tissue repair. Despite promising preclinical data, human clinical trials remain limited. Most evidence comes from rodent models, and the peptide's regulatory status varies by country. It is not FDA-approved for any medical condition. Users in the biohacking and athletic recovery communities report benefits for joint injuries, gut healing, and tendon repair, but these remain anecdotal.
Hydrolyzed collagen protein fragments used to support skin elasticity, joint health, and connective tissue repair.
A rich source of EPA and DHA omega-3 fatty acids, commonly used to support cardiovascular health and reduce inflammation.
A hormone naturally produced by the pineal gland that regulates sleep-wake cycles, commonly supplemented for sleep disorders and jet lag.
Nicotinamide mononucleotide (NMN) is a direct precursor to NAD+ (nicotinamide adenine dinucleotide), a coenzyme found in every living cell that participates in over 500 enzymatic reactions. NAD+ is essential for mitochondrial energy production, DNA repair via PARP enzymes, and activation of sirtuins — a family of seven proteins often called "longevity regulators." NAD+ levels decline significantly with age — by roughly 50% between ages 40 and 60 in some tissues. This decline is implicated in mitochondrial dysfunction, impaired DNA repair, metabolic disorders, and the broader phenotype of aging. NMN supplementation aims to restore NAD+ levels by providing the immediate biosynthetic precursor. Animal studies have demonstrated remarkable results: improved insulin sensitivity, enhanced mitochondrial function, increased exercise endurance, and extended healthspan in aged mice. The first long-term human clinical trial (2022) showed that 250mg NMN daily for 12 weeks increased blood NAD+ levels and improved muscle function in older men. However, the field is still young, and optimal dosing, long-term safety, and definitive anti-aging effects in humans remain under investigation.
Omega-3 fatty acids — specifically EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) — are polyunsaturated fats that the human body cannot synthesize de novo. They must be obtained from dietary sources, primarily fatty fish (salmon, mackerel, sardines, anchovies), shellfish, and marine algae. EPA and DHA serve as structural components of cell membranes throughout the body, with particularly high concentrations in the brain (DHA comprises roughly 40% of polyunsaturated fatty acids in the brain) and retina. Beyond structural roles, they are precursors to specialized pro-resolving mediators (SPMs) — resolvins, protectins, and maresins — that actively resolve inflammation rather than simply suppressing it. The evidence base for omega-3 supplementation is extensive. Large-scale trials and meta-analyses support benefits for cardiovascular health (triglyceride reduction, modest blood pressure lowering), inflammatory conditions, mood disorders, and cognitive maintenance. The American Heart Association recommends at least two servings of fatty fish per week, and higher-dose EPA supplementation has been shown to reduce cardiovascular events in the REDUCE-IT trial.
Alzheimer’s disease (AD) and cardiovascular disease (CVD) are tightly linked along a brain–heart axis. They share many modifiable risk factors—hypertension, diabetes, dyslipidemia, obesity, smoking...
