Condition / Condition Mental Health

ADHD and Anxiety

Attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders frequently co-occur across the lifespan. In children and adolescents with ADHD, about one-quarter to one-third have a current anxiety disorder, with higher lifetime rates. In adults with ADHD, meta-analyses estimate roughly 40–50% experience an anxiety disorder at some point. This overlap is clinically meaningful: anxiety can mask ADHD (especially in females and inattentive presentations), worsen executive dysfunction, and amplify social and academic/work impairment. Conversely, unrecognized ADHD can perpetuate worry and physiological hyperarousal through repeated failures, time blindness, and overstimulation. Shared mechanisms help explain the link. Both conditions show alterations in fronto-striatal and fronto-limbic circuits governing attention, salience, and emotion regulation; dysregulated catecholamines (dopamine/norepinephrine) and stress-axis signaling (HPA axis) are implicated. Genetic studies indicate a modest positive genetic correlation between ADHD and anxiety, and both are sensitive to sleep disruption, early-life stress, and circadian misalignment. Clinically, ADHD-related executive deficits (planning, organization, inhibition) can trigger secondary anxiety (e.g., fear of missing deadlines), while trait anxiety can further erode working memory and set-shifting, creating a feed-forward cycle. Assessment should screen for both conditions and prioritize the most impairing symptoms, recognizing that treating ADHD often reduces secondary anxiety by lowering daily chaos and improving task success. Evidence-based overlapping treatments include cognitive-behavioral approaches that target both anxious cognitions and executive skills, aerobic exercise, sleep optimization (including CBT-I where indicated), and mindfulness-based strategies. Pharmacologically, stimulants remain first-line for ADHD and typically do not worsen—and may improve—anxiety once ADHD symptoms remit, though a subset may

Updated February 21, 2026

This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication regimen.

Shared Risk Factors

Shared genetic liability

Moderate Evidence

Twin and genome-wide studies show a modest positive genetic correlation between ADHD and anxiety disorders, suggesting overlapping heritable risk.

Increases susceptibility to ADHD via neurodevelopmental pathways affecting dopaminergic/noradrenergic signaling.
Raises baseline risk for anxiety through neuroticism/negative affect traits and stress-response sensitivity.

Sleep disturbance and circadian misalignment

Moderate Evidence

Short sleep, delayed sleep phase, and irregular schedules impair attention and heighten arousal, fueling both inattention/impulsivity and anxious reactivity.

Worsens inattention, impulsivity, and emotional lability.
Increases physiological arousal and worry; poor sleep is a maintenance factor for anxiety.

Early-life stress and adverse childhood experiences (ACEs)

Moderate Evidence

Trauma, chronic stress, and inconsistent caregiving are linked with emotion dysregulation and HPA-axis changes.

Associated with more severe ADHD symptoms and externalizing comorbidity.
Strongly associated with anxiety disorders and hypervigilance.

Temperament: negative emotionality and emotional dysregulation

Strong Evidence

High reactivity, low distress tolerance, and rejection sensitivity contribute to both conditions’ onset and persistence.

Predicts greater impulsivity, frustration intolerance, and executive-control lapses.
Increases vulnerability to generalized worry, social anxiety, and panic.

Perinatal exposures (e.g., maternal stress, nicotine)

Emerging Research

Prenatal stress and toxin exposure associate with neurodevelopmental alterations and later internalizing symptoms.

Linked to higher ADHD risk and symptom severity in cohort studies.
Associated with greater internalizing symptoms, including anxiety.

Female sex/internalizing presentation

Moderate Evidence

Females with ADHD are more likely to present with inattentive symptoms and internalizing problems that overlap with anxiety, contributing to underdiagnosis and delayed care.

Increases missed or late ADHD diagnosis due to quieter inattentive profile.
Higher baseline risk for anxiety disorders, especially during adolescence.

Comorbidity Data

Prevalence

Children/adolescents with ADHD: ~25–35% have a current anxiety disorder; lifetime rates higher. Adults with ADHD: ~40–50% lifetime anxiety disorder prevalence.

Mechanistic Link

Overlapping fronto-limbic dysfunction, catecholaminergic signaling differences, HPA-axis hyperreactivity, sleep/circadian disruption, and shared genetic liability underlie co-occurrence. Executive dysfunction in ADHD can precipitate secondary anxiety; chronic anxiety further degrades executive control.

Clinical Implications

Screen routinely for both conditions. Sequence treatment to the most impairing domain; treating ADHD often reduces secondary anxiety. Behavioral therapy is beneficial for both. Choose medications thoughtfully: stimulants often help overall functioning and may ease anxiety once ADHD is controlled; consider atomoxetine or alpha-2 agonists when anxiety is prominent. Combine pharmacotherapy with CBT for optimal outcomes.

Sources (4)
  1. Simon V, Czobor P, Bálint S, Mészáros Á, Bitter I. Prevalence and correlates of adult ADHD: meta-analysis. Br J Psychiatry. 2009.
  2. Jensen PS et al. The MTA Study: comorbidity and treatment response. J Am Acad Child Adolesc Psychiatry. 2001.
  3. Kessler RC et al. The prevalence and effects of adult ADHD. Psychol Med. 2006.
  4. NICE Guideline NG87: Attention deficit hyperactivity disorder: diagnosis and management (2018/2019).

Overlapping Treatments

Cognitive-behavioral therapy (CBT) with executive-skills modules

Strong Evidence
Benefits for ADHD

Improves organization, time management, cognitive restructuring for procrastination and self-criticism.

Benefits for Anxiety

Addresses worry cycles, avoidance, and safety behaviors using exposure and cognitive strategies.

Requires engagement and practice; may be optimized when ADHD symptoms are reasonably controlled.

Aerobic exercise (moderate-to-vigorous, 120–150 min/week)

Moderate Evidence
Benefits for ADHD

Acute and chronic improvements in attention, working memory, and mood regulation.

Benefits for Anxiety

Reduces somatic tension and trait anxiety; enhances stress resilience.

Start gradually; schedule earlier in the day to protect sleep in sensitive individuals.

Sleep optimization and CBT-I where indicated

Moderate Evidence
Benefits for ADHD

Better vigilance, executive function, and emotion regulation.

Benefits for Anxiety

Meaningfully reduces anxiety severity and relapse risk.

Address caffeine, screens, and circadian regularity; rule out sleep apnea/RLS when suspected.

Mindfulness-based interventions (e.g., MBSR/MbCT adapted for ADHD)

Moderate Evidence
Benefits for ADHD

Improves sustained attention and self-regulation; reduces reactivity.

Benefits for Anxiety

Decreases worry and ruminative loops; improves interoceptive calm.

Effects are dose-dependent; guided programs outperform unguided apps.

Atomoxetine (non-stimulant SNRI)

Moderate Evidence
Benefits for ADHD

Reduces core ADHD symptoms.

Benefits for Anxiety

Evidence for concurrent reduction in anxiety symptoms in comorbid patients.

Titration over weeks; monitor for GI upset, sleep changes, rare mood effects.

Stimulants (methylphenidate/amphetamine class)

Strong Evidence
Benefits for ADHD

First-line, robust improvement in ADHD symptoms and functioning.

Benefits for Anxiety

Often indirectly reduce anxiety once executive control improves; a minority experience increased jitteriness early in treatment.

Start low/go slow in high-anxiety patients; monitor sleep, appetite, heart rate/BP.

Alpha-2A agonists (guanfacine ER, clonidine ER)

Moderate Evidence
Benefits for ADHD

Reduce hyperactivity/impulsivity and emotional lability.

Benefits for Anxiety

Lower autonomic arousal and can ease somatic anxiety.

Sedation and hypotension possible; caution with other sedatives.

Omega-3 (EPA-dominant, ~1–2 g/day combined EPA+DHA)

Emerging Research
Benefits for ADHD

Small-to-moderate benefit on ADHD symptoms in some meta-analyses.

Benefits for Anxiety

May reduce anxiety symptoms in individuals with elevated baseline anxiety/inflammation.

Adjunctive, not a replacement for first-line therapies; GI fishy aftertaste possible.

HRV-biofeedback and paced breathing

Emerging Research
Benefits for ADHD

Improves emotional regulation and attention in small studies.

Benefits for Anxiety

Reduces physiological arousal and anxiety.

Access and adherence limit effect sizes; best with trained coaching.

Medical Perspectives

Western Perspective

Western medicine views ADHD and anxiety as distinct but frequently comorbid neuropsychiatric disorders with shared risk factors and bidirectional maintenance loops. Best practice emphasizes differential diagnosis, measuring impairment across settings, and integrated treatment plans that combine pharmacotherapy with skills-based psychotherapy and lifestyle interventions.

Key Insights

  • Comorbidity is common; anxiety can mask inattentive ADHD, especially in females.
  • Treat the most impairing condition first; controlling ADHD often reduces secondary anxiety.
  • CBT tailored to executive dysfunction is synergistic with exposure-based CBT for anxiety.
  • Stimulants typically do not worsen—and may improve—anxiety once ADHD symptoms remit; atomoxetine is an option when anxiety is prominent.
  • Address sleep, exercise, and substance use because they modulate both symptom sets.

Treatments

  • ADHD: stimulants (methylphenidate/amphetamine), atomoxetine, guanfacine/clonidine; CBT for ADHD; coaching.
  • Anxiety: CBT with exposure, SSRIs/SNRIs, buspirone (for GAD), mindfulness-based therapies; avoid routine benzodiazepines in ADHD due to dependence/cognitive risks.
  • Cross-cutting: sleep optimization/CBT-I, aerobic exercise, mindfulness/HRV-biofeedback, omega-3 as adjunct.
Evidence: Strong Evidence

Sources

  • NICE NG87: Attention deficit hyperactivity disorder (2018/2019).
  • Canadian ADHD Practice Guidelines, 4.1 (2021).
  • Kratochvil CJ et al. Atomoxetine for ADHD with comorbid anxiety. J Am Acad Child Adolesc Psychiatry. 2005.
  • Simon V et al. Adult ADHD comorbidity meta-analysis. Br J Psychiatry. 2009.

Eastern Perspective

In Traditional Chinese Medicine (TCM), ADHD and anxiety are viewed as patterns of disharmony affecting the Heart (Shen/mind), Liver (qi flow), Spleen (transformation/transport), and Kidney (essence). Overlapping patterns—such as Heart-Spleen deficiency, Liver qi stagnation with phlegm-heat, and yin deficiency with empty heat—can manifest as distractibility, restlessness, insomnia, and worry. Treatment aims to calm the Shen, harmonize qi, clear phlegm-heat, and nourish deficiencies through acupuncture, herbal formulas, and lifestyle practices.

Key Insights

  • Shared patterns (e.g., Heart-Spleen qi deficiency; Liver qi stagnation) can present as both agitation/inattention and anxious rumination.
  • Insomnia and palpitations reflect Shen disturbance; addressing sleep is central in both conditions.
  • Regulating daily rhythm (meals, movement, light) is emphasized to settle the Shen and anchor attention.

Treatments

  • Acupuncture protocols commonly include Yintang (EX-HN3), Shenmen (HT7), Sanyinjiao (SP6), Baihui (DU20), and auricular Shenmen to calm the Shen and regulate autonomic tone.
  • Herbal approaches tailored to pattern: Suan Zao Ren Tang (insomnia/anxiety with yin-blood deficiency); An Shen Ding Zhi Wan (palpitations, timidity, poor concentration); Chai Hu Long Gu Mu Li Tang (restlessness with constraint/yang rising).
  • Mind-body: breathwork, qigong/taiji to smooth Liver qi and build parasympathetic tone.
Evidence: Emerging Research

Sources

  • Amorim D et al. Acupuncture for anxiety: systematic review/meta-analysis. Complement Ther Clin Pract. 2018.
  • Sampaio LV et al. Acupuncture for ADHD: systematic review. Medicine (Baltimore). 2021.
  • Bensky D, Clavey S, Stöger E. Chinese Herbal Medicine: Materia Medica, 3rd ed. 2004.

Evidence Ratings

~25–35% of youth with ADHD have a current anxiety disorder; adult ADHD shows ~40–50% lifetime anxiety.

Simon V et al., 2009; Jensen PS et al., 2001; Kessler RC et al., 2006.

Strong Evidence

Treating ADHD often reduces secondary anxiety by improving executive control and daily functioning.

NICE NG87 (2018/2019); Canadian ADHD Practice Guidelines (2021).

Moderate Evidence

Stimulants generally do not worsen, and may improve, anxiety once ADHD symptoms are controlled.

NICE NG87; Canadian ADHD Practice Guidelines; clinical trials/meta-analyses referenced therein.

Moderate Evidence

Atomoxetine improves ADHD and can reduce comorbid anxiety symptoms.

Kratochvil CJ et al., 2005 RCT in pediatric ADHD with anxiety.

Moderate Evidence

CBT with executive-skills components benefits both ADHD and anxiety.

NICE NG87; multiple CBT for ADHD and anxiety meta-analyses.

Strong Evidence

Aerobic exercise improves attention and reduces anxiety.

Den Heijer AE et al., 2017 systematic review; Cooney GM et al., 2013 exercise for anxiety/depression.

Moderate Evidence

Omega-3 supplementation yields small benefits for ADHD and may reduce anxiety in high-anxiety groups.

Bloch & Qawasmi, 2011; Chang JP et al., 2018; Su KP et al., 2018 anxiety meta-analysis.

Emerging Research

Acupuncture can reduce anxiety symptoms; evidence for ADHD is limited and mixed.

Amorim D et al., 2018; Sampaio LV et al., 2021.

Emerging Research

ADHD and anxiety share a modest genetic correlation.

Brainstorm Consortium, 2018; Demontis D et al., 2019 ADHD GWAS.

Moderate Evidence

Western Medicine Perspective

ADHD and anxiety frequently travel together and interact in clinically important ways. Executive dysfunction inherent to ADHD creates a fertile ground for chronic stress: missed deadlines, disorganization, and inconsistent performance drive anticipatory worry and hyperarousal. Anxiety then feeds back to impair working memory, attentional shifting, and inhibition, worsening the very executive functions that ADHD already taxes. Neurobiologically, both conditions involve dysregulation within fronto-striatal and fronto-limbic networks and altered catecholamine signaling; both are sensitive to sleep loss and circadian delay. Genetic data support partially shared heritability, while environmental contributors such as adverse childhood experiences further heighten risk for both. Evaluation should include structured screening for each condition, collateral information across settings, and a functional impairment focus. Treatment sequencing generally targets the most impairing domain; in many cases, optimizing ADHD management alleviates a substantial proportion of secondary anxiety. Stimulants are first-line for ADHD and, when titrated thoughtfully, often improve overall calm by restoring task control; atomoxetine is an evidence-based alternative when anxiety is prominent or stimulants are poorly tolerated. Adding CBT tailored to ADHD (organization, time management, cognitive restructuring around procrastination) and standard CBT for anxiety (exposures, worry management) provides additive benefits. Lifestyle interventions—regular aerobic exercise, sleep optimization or CBT-I, mindfulness/HRV-biofeedback—are low-risk, cross-cutting supports that can reduce arousal and improve attention. SSRIs/SNRIs treat primary anxiety but should be combined with ADHD-focused therapy or medication to address executive deficits; benzodiazepines are generally avoided due to dependence and cognitive dulling. Ongoing monitoring is key, as symptom balance and treatment tolerability can shift over time.

Eastern Medicine Perspective

From a TCM perspective, the shared features of ADHD and anxiety—restlessness, distractibility, insomnia, palpitations—reflect Shen (mind/spirit) disturbance arising from different pattern constellations. Heart-Spleen deficiency can yield poor concentration, fatigue, and worry; Liver qi stagnation with phlegm-heat may present as irritability, impulsivity, and racing thoughts; yin deficiency with empty heat leads to insomnia, agitation, and anxiety. Because these patterns overlap, a single individualized plan can address both conditions by calming the Shen, harmonizing qi, clearing phlegm-heat, and nourishing deficiency. Acupuncture selections such as Yintang, HT7 (Shenmen), SP6 (Sanyinjiao), and DU20 (Baihui) are used to modulate autonomic tone and quiet internal agitation. Auricular acupuncture at Shenmen is commonly added for anxiety. Herbal formulas are chosen by pattern: Suan Zao Ren Tang (yin-blood deficiency with insomnia/anxiety), An Shen Ding Zhi Wan (timidity, palpitations, poor concentration), or Chai Hu Long Gu Mu Li Tang (constraint with yang rising). Gentle daily practices—regulated sleep-wake cycles, warm cooked foods at regular times, qigong/taiji, and breathwork—aim to smooth Liver qi and anchor the Shen. While clinical tradition is strong, modern evidence is still developing: small randomized trials suggest acupuncture can reduce anxiety symptoms, but findings for ADHD are mixed and heterogeneous. Accordingly, TCM approaches are best considered complementary to, not replacements for, established Western therapies, and should be guided by a licensed practitioner with attention to herb–drug interactions and individual safety.

Sources
  1. NICE Guideline NG87: Attention deficit hyperactivity disorder: diagnosis and management (2018, updated 2019). https://www.nice.org.uk/guidance/ng87
  2. Canadian ADHD Practice Guidelines, 4.1 Edition. CADDRA; 2021. https://www.caddra.ca/
  3. Simon V, Czobor P, Bálint S, Mészáros Á, Bitter I. Prevalence and correlates of adult ADHD: meta-analysis. Br J Psychiatry. 2009;194(3):204-211. doi:10.1192/bjp.bp.107.048827
  4. Jensen PS et al. Comorbidity and the Multimodal Treatment Study of ADHD (MTA). J Am Acad Child Adolesc Psychiatry. 2001;40(2):147-158. doi:10.1097/00004583-200102000-00008
  5. Kessler RC et al. The prevalence and effects of adult ADHD. Psychol Med. 2006;36(2):159-167. doi:10.1017/S0033291705006140
  6. Kratochvil CJ, Newcorn JH, Arnold LE, et al. Atomoxetine treatment for pediatric patients with ADHD and comorbid anxiety. J Am Acad Child Adolesc Psychiatry. 2005;44(9):915-924. doi:10.1097/01.chi.0000169018.91580.63
  7. Den Heijer AE et al. The effects of physical activity on executive functions in children with ADHD: a systematic review and meta-analysis. J Atten Disord. 2017;21(11):993-1005. doi:10.1177/1087054714547067
  8. Cooney GM et al. Exercise for anxiety disorders: systematic review. Cochrane Database Syst Rev. 2013;(9):CD004366. doi:10.1002/14651858.CD004366.pub2
  9. Bloch MH, Qawasmi A. Omega-3 fatty acid supplementation for the treatment of children with ADHD: meta-analysis. J Am Acad Child Adolesc Psychiatry. 2011;50(10):991-1000. doi:10.1016/j.jaac.2011.06.008
  10. Chang JP et al. Omega-3 PUFAs in ADHD: systematic review and meta-analysis. Neuropsychopharmacology. 2018;43:534–545. doi:10.1038/npp.2017.160
  11. Su KP et al. Omega-3 PUFAs for anxiety symptoms: systematic review and meta-analysis. JAMA Netw Open. 2018;1(5):e182327. doi:10.1001/jamanetworkopen.2018.2327
  12. Amorim D et al. Acupuncture for anxiety disorders: systematic review/meta-analysis. Complement Ther Clin Pract. 2018;31:31-37. doi:10.1016/j.ctcp.2018.01.008
  13. Sampaio LV et al. Acupuncture for ADHD: systematic review. Medicine (Baltimore). 2021;100(17):e25672. doi:10.1097/MD.0000000000025672
  14. The Brainstorm Consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018;360(6395). doi:10.1126/science.aap8757
  15. Demontis D et al. Discovery of the first genome-wide significant risk loci for ADHD. Nat Genet. 2019;51:63–75. doi:10.1038/s41588-018-0269-7
  16. American Academy of Pediatrics. ADHD Clinical Practice Guideline. Pediatrics. 2019;144(4):e20192528. doi:10.1542/peds.2019-2528

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Health Disclaimer

This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication regimen.