Article: Imipenem/cilastatin

Imipenem/cilastatin is a broad spectrum beta-lactam antibiotic containing equal quantities of imipenem and cilastatin. Imipenem, the active antibacterial agent, is rapidly degraded by the renal enzyme dehydropeptidase if administered alone. Cilastatin is a dehydropeptidase inhibitor, with no intrinsic antibacterial activity, and must be co-administered with imipenem to ensure its efficacy. Imipenem/cilastatin is marketed by Merck & Co. under the trade names Primaxin and Tienam.

See also

  • Imipenem
  • Cilastatin
Retrieved from "http://en.wikipedia.org/wiki/Imipenem/cilastatin"

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