Morphine for the Treatment of Pain in Patients With Breast Cancer - Article Avinza; Kadian; MS Contin; Oramorph SR
Clinical Trial: Morphine for the Treatment of Pain in Patients With Breast Cancer
This study is no longer recruiting patients.
PURPOSE: Randomized clinical trial to compare the effectiveness of morphine injected directly into the underarm area with morphine injected into the back of the shoulder in treating pain in patients who have breast cancer and who are undergoing axillary lymph node dissection.
|Condition||Treatment or Intervention|
|Pain || Drug: fentanyl |
MedlinePlus related topics: Pain
Study Type: Interventional
Study Design: Educational/Counseling/Training
Study start: May 1992
PROTOCOL OUTLINE: This is a prospective, double blind, randomized study.
Patients are randomized into 3 groups with 6 patients in each group. Group 1 receives morphine diluted in normal saline (NS), which is administered in the axillary region at the completion of surgery before surgical closure. The area is flooded and the solution is allowed to remain in the wound for 5 minutes. Group 2 (control group) receives NS only, administered in the same fashion as group 1. Group 3 receives morphine subcutaneously in the deltoid area, ipsilateral to the site of surgery, at the beginning of wound closure. Postoperatively, patients self-administer IV fentanyl analgesia through a patient controlled analgesia pump. Comparisons of daily IV fentanyl utilization is done among the three groups. Quality of pain is assessed via visual analog pain scores four times a day at 2, 4, 6, and 24 hours postoperatively.
PROJECTED ACCRUAL: A total of 18 patients will be accrued over a period of 2 years.
PROTOCOL ENTRY CRITERIA:
- No oral-equivalent doses of morphine greater than 10 mg a day
-- Patient Characteristics--
- Age: Not specified
- Sex: Not specified
- Other: Not allergic to morphine
Roswell Park Cancer Institute, Buffalo, New York, 14263-0001, United States
Anthony T. Yarussi, Study Chair, Roswell Park Cancer Institute
Record last reviewed: July 2004
Last Updated: October 13, 2004
Record first received: November 1, 1999
ClinicalTrials.gov Identifier: NCT00003000
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08
Cache Date: April 9, 2005