Protein C is a major physiological anticoagulant. It is a vitamin K-dependant serine protease enzyme (EC that is activated by thrombin into activated protein C (APC). The activated form (with protein S as a cofactor) degrades Factor Va and Factor VIIIa.


... Why get tested?
To help evaluate a thrombotic episode, to determine whether you may have an inherited or acquired Protein C or Protein S deficiency

When to get tested?
When you have had an unexplained thromboembolism (a blood vessel blocked by a blood clot), when your newborn has a severe clotting disorder, such as disseminated intravascular coagulation (DIC) or purpura fulminans; sometimes when a close relative has an inherited Protein C or Protein S deficiency

Sample required?
A blood sample drawn from a vein in your arm
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