The insulin-like growth factors (IGFs) are polypeptides with high sequence similarity to insulin. They can trigger the same cellular responses as insulin, including mitogenesis in cell culture. IGF-II is thought to be a primary growth factor required for early development while IGF-I expression is seen in later life. Gene knockout studies in mice have confirmed this though other animals are likely to regulate the expression of these genes in distinct ways. ...


... Why get tested?
To identify diseases and conditions caused by deficiencies and overproduction of growth hormone (GH), to evaluate pituitary function, and to monitor the effectiveness of GH treatment

When to get tested?
As part of an evaluation of pituitary function; if you have symptoms of slow growth, short stature, and delayed development (in children) or decreased bone density, reduced muscle strength, and increased lipids (in adults) that suggest insufficient GH and IGF-1 production; if you have symptoms of gigantism (in children) or acromegaly (in adults) that suggest excess GH and IGF-1 production; during and after treatment for GH abnormalities

Sample required?
A blood sample drawn from a vein in your arm or by a fingerstick (in children)
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  • IGF-1 (Lab Tests Online)