Clinical Trial: Study for Subjects with Chronic Kidney Disease (CKD) Not Receiving Dialysis

This study is no longer recruiting patients.

Sponsored by: Amgen
Information provided by: Amgen

Purpose

The proposed study is designed to test a novel dosing paradigm that would facilitate the treatment of anemia in CKD patients not on dialysis. Anemic patients who have achieved and maintained target hemoglobin (Hb) on every 2 weeks (Q2W) dosing of darbepoetin alfa will have the dosing interval extended to once monthly (QM) dosing. Extending the dosing interval for darbepoetin alfa to QM represents a major potential benefit to both patients with CKD and their caregivers.

Condition Treatment or Intervention Phase
Chronic Kidney Disease
Kidney Diseases
 Drug: De Novo Administration of Darbepoetin Alfa
Phase III

MedlinePlus related topics:  Kidney Diseases

Study Type: Interventional
Study Design: Treatment, Single Blind

Official Title: A Multi-Center, Single-Arm Study Evaluating De Novo Once Every Two Week Darbepoetin Alfa Dosing in Subjects with Chronic Kidney Disease (CKD) Not Receiving Dialysis

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

  • Diagnosis of CKD and not expected to initiate dialysis for the duration of the study
  • Estimated glomerular filtration rate (eGFR): greater than or equal to 15 mL/min and less than or equal to 60 mL/min measured by the following modified MDRD (Modification of Diet in Renal Disease) equation: eGFR = 186 x [serum creatinine]-1.154 x [Age]-0.203 x [0.742 if subject is female] x [1.212 if subject is black]
  • Clinically stable, in the judgment of the investigator
  • Mean Hb greater than or equal to 11.0 g/dL to less than or equal to 13.0 g/dL (mean of 2 values drawn at least 3 days apart during the screening period)
  • Transferrin saturation (Tsat) greater than or equal to 15.0%
  • Serum vitamin B12 and folate levels above the lower limit of the normal range
  • Receiving stable Q2W subcutaneous (SC) doses of Aranesp® (darbepoetin alfa). A stable dose is defined as less than or equal to a 25% change in dose over the 6-week period immediately prior to enrollment and with no missed doses in this period

Exclusion Criteria:

  • Prior recipient or scheduled to receive a kidney transplant
  • Diastolic blood pressure (BP) greater than 110 mm Hg or systolic BP greater than 180 mm Hg during screening
  • Acute myocardial ischemia
  • Hospitalization for congestive heart failure or myocardial infarction within 12 weeks before enrollment
  • Parathyroid hormone level greater than 1500 pg/mL
  • Major surgery within 12 weeks before enrollment (excluding vascular access surgery)
  • Currently receiving antibiotic therapy for systemic infection
  • Known positive HIV antibody or positive hepatitis B surface antigen
  • Clinical evidence of current malignancy and/or receiving systemic chemotherapy/radiotherapy with the exception of basal cell or squamous cell carcinoma of the skin and cervical intraepithelial neoplasia
  • Red blood cell (RBC) transfusions within 8 weeks before enrollment
  • Androgen therapy within 8 weeks before enrollment
  • Systemic hematologic disease (e.g., sickle cell anemia, myelodysplastic syndromes, hematologic malignancy, myeloma, hemolytic anemia)
  • Any disorder that may impact (in the judgment of the investigator) the ability to give informed consent for participation in this study
  • Pregnant or breast-feeding women
  • All subjects must practice adequate contraception (in the judgment of the investigator) throughout this trial
  • Treatment with an investigational agent or device within 30 days before enrollment or scheduled to receive an investigational agent other than those specified by this protocol during the course of this study

More Information

Study ID Numbers:  20030237
Record last reviewed:  May 2005
Last Updated:  May 27, 2005
Record first received:  May 27, 2005
ClinicalTrials.gov Identifier:  NCT00112008
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-05-31

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