Clinical Trial: Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors

This study is no longer recruiting patients.

Sponsors and Collaborators: Children's Oncology Group
National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)

Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. It is not yet known which therapy regimen is most effective for treating patients with kidney tumors.

PURPOSE: Phase III trial to compare the effectiveness of chemotherapy with or without radiation therapy, surgery, and/or peripheral stem cell or bone marrow transplantation in treating young patients with kidney tumors.

Condition Treatment or Intervention Phase
recurrent Wilms' tumor and other childhood kidney tumors
clear cell sarcoma of the kidney
rhabdoid tumor of the kidney
 Drug: carboplatin
 Drug: cyclophosphamide
 Drug: dactinomycin
 Drug: doxorubicin
 Drug: etoposide
 Drug: filgrastim
 Drug: vincristine
 Procedure: biological response modifier therapy
 Procedure: chemotherapy
 Procedure: colony-stimulating factor therapy
 Procedure: conventional surgery
 Procedure: cytokine therapy
 Procedure: radiation therapy
 Procedure: surgery
Phase III

MedlinePlus related topics:  Cancer;   Cancer Alternative Therapy;   Kidney Cancer;   Soft Tissue Sarcoma

Study Type: Interventional
Study Design: Treatment

Official Title: Phase III Study of Multimodality Therapy Based on Prior Therapy and Histology in Patients With Relapsed Wilms' Tumor

Further Study Details: 

OBJECTIVES:

OUTLINE: This is a multicenter study.

Patients are assigned to a treatment group based on initial therapy and histology. Patients under age 2 at diagnosis who were previously treated with nephrectomy as initial therapy for stage I favorable histology Wilms' tumor weighing less than 550 grams are assigned to group A. Patients who received Regimen EE-4A as initial therapy for Wilms' tumor are assigned to group B. Patients who received Regimen DD-4A as initial therapy for Wilms' tumor are assigned to group C. Patients with clear cell sarcoma of the kidney or diffuse anaplastic Wilms' tumor are assigned to group D.

Group A

Group B

  • Patients undergo resection. After resection, patients receive regimen I comprising DOX IV on weeks 0, 6, 12, 18, and 24; VCR IV on weeks 1, 2, 4, 5-8, 10-13, 18, and 24; cyclophosphamide (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; and etoposide (VP-16) IV over 1 hour (after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21 in the absence of disease progression. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy and continuing until blood counts recover. Patients undergo radiotherapy to site of recurrence beginning within 1 week after initiation of chemotherapy.

Group C

  • Induction: Patients receive CTX IV over 1 hour on days 1-5 of weeks 0 and 3; VP-16 IV over 1 hour (after CTX infusion) on days 1-5 of weeks of 0 and 3 and on days 1-3 of weeks 6 and 9; and carboplatin (CBDCA) IV over 6 hours on days 1 and 2 of weeks 6 and 9 in the absence of disease progression. G-CSF is administered SC beginning 24 hours after completion of CTX/VP-16 or CBDCA/VP-16 and continuing until blood counts recover.
  • Surgery: Patients with detectable disease undergo resection on week 13. If complete resection is not achieved or if it is deemed impossible, resection must be attempted no later than 3 weeks after consolidation radiotherapy.
  • Consolidation: Beginning within 9 days of surgery, patients receive CTX IV over 1 hour on days 1-5 of week 1; VP-16 IV over 1 hour (after CTX infusion) on days 1-5 of week 1 and on days 1-3 of week 4; CBDCA IV over 6 hours on days 1 and 2 of week 4; G-CSF as in induction; and radiotherapy in the absence of disease progression. Patients with complete or partial response after resection and/or radiotherapy proceed to maintenance therapy.
  • Maintenance: Patients receive CTX IV over 1 hour on days 1-5 of weeks 0 and 3; VP-16 IV over 1 hour on days 1-5 of weeks 0 and 3 and on days 1-3 of weeks 6 and 9; CBDCA IV over 6 hours on days 1 and 2 of weeks 6 and 9; and G-CSF as in induction. Treatment continues every 12 weeks for 6 courses in the absence of disease progression.

Group D

  • Patients receive CBDCA IV over 6 hours on days 1 and 2 and VP-16 IV over 1 hour (after CBDCA infusion) on days 1-3 of weeks 0 and 3. Treatment continues weekly for 6 courses in the absence of disease progression. Patients are followed every 3 months for 15 months, every 6 months for 1 year, and then annually for 3 years.

PROJECTED ACCRUAL: Not specified

Eligibility

Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

  • Diagnosis of Wilms' tumor
  • Eligible subtypes:
  • Favorable histologies
  • Anaplastic histologies
  • Clear cell sarcoma of the kidney
  • Rhabdoid tumor of the kidney
  • Relapsed disease after entry on protocol NWTS-5 (NWTS-Q9401)

PATIENT CHARACTERISTICS: Age:

  • 21 and under at original diagnosis

Performance status:

  • Not specified

Life expectancy:

  • At least 4 weeks

Hematopoietic:

  • Absolute neutrophil count at least 1,000/mm^3
  • Platelet count at least 100,000/mm^3

Hepatic:

  • Bilirubin no greater than 1.5 times normal
  • SGOT or SGPT less than 2.5 times normal

Renal:

  • Creatinine no greater than 1.5 times normal OR
  • Creatinine clearance or GFR at least 70 mL/min

Cardiovascular:

  • Shortening fraction at least 27% by echocardiogram OR
  • Ejection fraction greater than 50% by echocardiogram or MUGA scan

Other:

  • Not pregnant
  • Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy

  • Not specified

Chemotherapy

Endocrine therapy

  • Not specified

Radiotherapy

  • Not specified

Surgery

  • Not specified

Other

  • No prior therapy for relapsed Wilms' tumor
  • Recovered from the toxic effects of any other prior therapy

Location Information


Alabama
      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35233,  United States

      University of South Alabama Medical Center, Mobile,  Alabama,  36604,  United States

Arizona
      Arizona Cancer Center, Tucson,  Arizona,  85724,  United States

      Phoenix Children's Hospital, Phoenix,  Arizona,  85016-7710,  United States

Arkansas
      University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States

California
      Cedars-Sinai Medical Center, Los Angeles,  California,  90048,  United States

      Chao Family Comprehensive Cancer Center, Orange,  California,  92868,  United States

      Children's Hospital Central California, Madera,  California,  93638-8762,  United States

      Children's Hospital Los Angeles, Los Angeles,  California,  90027-0700,  United States

      Children's Hospital of Oakland, Oakland,  California,  94609-1809,  United States

      Children's Hospital of Orange County, Orange,  California,  92868,  United States

      Children's Hospital San Diego, San Diego,  California,  92123-4282,  United States

      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States

      David Grant Medical Center, Travis Air Force Base,  California,  94535,  United States

      Jonathan Jaques Children's Cancer Center, Long Beach,  California,  90801-1428,  United States

      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States

      Kaiser Permanente Medical Center - San Francisco Geary Campus, San Francisco,  California,  94115,  United States

      Kaiser Permanente Medical Center - Santa Clara, Santa Clara,  California,  95051-5386,  United States

      Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego,  California,  92120,  United States

      Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States

      Lucile Packard Children's Hospital at Stanford, Palo Alto,  California,  94304,  United States

      Rebecca and John Moores UCSD Cancer Center, La Jolla,  California,  92093-0658,  United States

      Santa Barbara Cottage Hospital, Santa Barbara,  California,  93102,  United States

      Southern California Permanente Medical Group, Downey,  California,  90242,  United States

      Sutter Cancer Center, Sacramento,  California,  95816,  United States

      UCSF Comprehensive Cancer Center, San Francisco,  California,  94143-0128,  United States

      University of California Davis Medical Center, Sacramento,  California,  95817,  United States

Colorado
      Childhood Hematology/Oncology Associates, Denver,  Colorado,  80218,  United States

      Children's Hospital of Denver, Denver,  Colorado,  80218-1088,  United States

      Presbyterian-St Luke's Medical Center, Denver,  Colorado,  80218,  United States

Connecticut
      University of Connecticut Health Center, Farmington,  Connecticut,  06360-7106,  United States

      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8028,  United States

Delaware
      Alfred I. Dupont Institute, Wilmington,  Delaware,  19899,  United States

District of Columbia
      Children's National Medical Center, Washington,  District of Columbia,  20010-2970,  United States

      Lombardi Cancer Center, Washington,  District of Columbia,  20007,  United States

      Walter Reed Army Medical Center, Washington,  District of Columbia,  20307-5000,  United States

Florida
      All Children's Hospital, St. Petersburg,  Florida,  33701,  United States

      Baptist Hospital of Miami, Miami,  Florida,  33176-2197,  United States

      Broward General Medical Center, Fort Lauderdale,  Florida,  33316,  United States

      Children's Hospital of Southwest Florida, Fort Myers,  Florida,  33908,  United States

      Florida Hospital Cancer Institute, Orlando,  Florida,  32803,  United States

      Joe DiMaggio Children's Hospital at Memorial, Hollywood,  Florida,  33021,  United States

      Miami Children's Hospital, Miami,  Florida,  33155-4069,  United States

      Nemours Children's Clinic, Jacksonville,  Florida,  32207,  United States

      Nemours Children's Clinic-Orlando, Orlando,  Florida,  32806,  United States

      Sacred Heart Children's Hospital, Pensacola,  Florida,  32504,  United States

      Shands Hospital and Clinics, University of Florida, Gainesville,  Florida,  32610-100277,  United States

      St. Mary's Hospital, West Palm Beach,  Florida,  33407,  United States

      Tampa Children's Hospital, Tampa,  Florida,  33677-4227,  United States

      University of Miami-Jackson Memorial Hospital, Miami,  Florida,  33136,  United States

Georgia
      Children's Healthcare of Atlanta - Scottish Rite, Atlanta,  Georgia,  30342,  United States

      Emory University Hospital - Atlanta, Atlanta,  Georgia,  30322,  United States

      Medical Center of Central Georgia, Macon,  Georgia,  31201,  United States

      Medical College of Georgia Comprehensive Cancer Center, Augusta,  Georgia,  30912-4000,  United States

      Memorial Health University Medical Center, Inc., Savannah,  Georgia,  31403-3089,  United States

Hawaii
      Cancer Research Center of Hawaii, Honolulu,  Hawaii,  96813,  United States

      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States

      Tripler Army Medical Center, Honolulu,  Hawaii,  96859-5000,  United States

Idaho
      Mountain States Tumor Institute, Boise,  Idaho,  83712,  United States

Illinois
      Children's Memorial Hospital - Chicago, Chicago,  Illinois,  60614,  United States

      Hope Children's Hospital, Oak Lawn,  Illinois,  60453,  United States

      Lutheran General Hospital, Park Ridge,  Illinois,  60068-1174,  United States

      Rush-Presbyterian-St. Luke's Medical Center, Chicago,  Illinois,  60612,  United States

      Saint Jude Midwest Affiliate, Peoria,  Illinois,  61637,  United States

      Southern Illinois University School of Medicine, Springfield,  Illinois,  62794-9658,  United States

      University of Chicago Cancer Research Center, Chicago,  Illinois,  60601,  United States

      University of Illinois at Chicago, Chicago,  Illinois,  60612,  United States

Indiana
      Indiana University Cancer Center, Indianapolis,  Indiana,  46202-5289,  United States

      St. Vincent Hospital and Health Care Center, Indianapolis,  Indiana,  46260,  United States

Iowa
      Holden Comprehensive Cancer Center, Iowa City,  Iowa,  52242-1009,  United States

      John Stoddard Cancer Center, Des Moines,  Iowa,  50309,  United States

      Raymond Blank Memorial Hospital for Children, Des Moines,  Iowa,  50308,  United States

Kansas
      Wesley Medical Center, Wichita,  Kansas,  67214,  United States

Kentucky
      Albert B. Chandler Medical Center, University of Kentucky, Lexington,  Kentucky,  40536-0284,  United States

      Kosair Children's Hospital, Louisville,  Kentucky,  40202-3830,  United States

Louisiana
      Children's Hospital of New Orleans, New Orleans,  Louisiana,  70118,  United States

      Ochsner Clinic, New Orleans,  Louisiana,  70121,  United States

      Tulane University School of Medicine, New Orleans,  Louisiana,  70112,  United States

Maine
      Eastern Maine Medical Center, Bangor,  Maine,  04401,  United States

      Maine Children's Cancer Program, Scarborough,  Maine,  04074,  United States

Maryland
      Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore,  Maryland,  21201-1595,  United States

      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States

      Sinai Hospital of Baltimore, Baltimore,  Maryland,  21225,  United States

Massachusetts
      Baystate Medical Center, Springfield,  Massachusetts,  01107,  United States

      Dana-Farber Cancer Institute, Boston,  Massachusetts,  02115,  United States

      Floating Hospital for Children, Boston,  Massachusetts,  02111,  United States

      University of Massachusetts Memorial Medical Center - University Campus, Worcester,  Massachusetts,  01655,  United States

Michigan
      Bronson Methodist Hospital, Kalamazoo,  Michigan,  49007,  United States

      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States

      Children's Hospital of Michigan, Detroit,  Michigan,  48201,  United States

      Henry Ford Hospital, Detroit,  Michigan,  48202,  United States

      Hurley Medical Center, Flint,  Michigan,  48503,  United States

      Michigan State University, East Lansing,  Michigan,  48824,  United States

      Mott Children's Hospital, Ann Arbor,  Michigan,  48109-0914,  United States

      Spectrum Health and DeVos Children's Hospital, Grand Rapids,  Michigan,  49503,  United States

      St. John Hospital and Medical Center, Detroit,  Michigan,  48236,  United States

      William Beaumont Hospital, Royal Oak,  Michigan,  48073-6769,  United States

Minnesota
      Children's Hospitals and Clinics - Minneapolis, Minneapolis,  Minnesota,  55404,  United States

      Children's Hospitals and Clinics of Minnesota, Saint Paul,  Minnesota,  55102,  United States

      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905,  United States

      St. Mary's/Duluth Clinic Cancer Center, Duluth,  Minnesota,  55805-1983,  United States

Mississippi
      University of Mississippi Medical Center, Jackson,  Mississippi,  39216-4505,  United States

Missouri
      Cardinal Glennon Children's Hospital, Saint Louis,  Missouri,  63104,  United States

      Children's Mercy Hospital, Kansas City,  Missouri,  64108,  United States

      St. Louis Children's Hospital, Saint Louis,  Missouri,  63110,  United States

Nebraska
      Children's Hospital of Omaha, Omaha,  Nebraska,  68114,  United States

      University of Nebraska Medical Center, Omaha,  Nebraska,  68198-2168,  United States

Nevada
      Sunrise Hospital and Medical Center, Las Vegas,  Nevada,  89109-2306,  United States

New Hampshire
      Norris Cotton Cancer Center, Lebanon,  New Hampshire,  03756-0002,  United States

New Jersey
      Atlantic Health System, Summit,  New Jersey,  07901,  United States

      Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08903,  United States

      Hackensack University Medical Center, Hackensack,  New Jersey,  07601,  United States

      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112-2094,  United States

      St. Joseph's Hospital and Medical Center, Paterson,  New Jersey,  07503,  United States

New Mexico
      University of New Mexico Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131,  United States

New York
      Albert Einstein Clinical Cancer Center, Bronx,  New York,  10461,  United States

      Brookdale University Hospital and Medical Center, Brooklyn,  New York,  11212,  United States

      Brooklyn Hospital Center, Brooklyn,  New York,  11201,  United States

      Cancer Center of Albany Medical Center, Albany,  New York,  12208,  United States

      Columbia Presbyterian Hospital, New York,  New York,  10032,  United States

      James P. Wilmot Cancer Center, Rochester,  New York,  14642,  United States

      Maimonides Medical Center, Brooklyn,  New York,  11219,  United States

      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States

      Mount Sinai School of Medicine, New York,  New York,  10029,  United States

      New York Medical College, Valhalla,  New York,  10595,  United States

      New York Presbyterian Hospital - Cornell Campus, New York,  New York,  10021-4885,  United States

      North Shore University Hospital, Manhasset,  New York,  11030,  United States

      Roswell Park Cancer Institute, Buffalo,  New York,  14263-0001,  United States

      Schneider Children's Hospital, New Hyde Park,  New York,  11042,  United States

      State University of New York - Upstate Medical University, Syracuse,  New York,  13210,  United States

      State University of New York Health Science Center at Brooklyn College of Medicine, Brooklyn,  New York,  11203,  United States

      State University of New York Health Sciences Center - Stony Brook, Stony Brook,  New York,  11790-7775,  United States

North Carolina
      Carolinas Medical Center, Charlotte,  North Carolina,  28232-2861,  United States

      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1081,  United States

      Duke Comprehensive Cancer Center, Durham,  North Carolina,  27710,  United States

      East Carolina University School of Medicine, Greenville,  North Carolina,  27858-4354,  United States

      Lineberger Comprehensive Cancer Center, UNC, Chapel Hill,  North Carolina,  27599-7295,  United States

      Mission Saint Joseph's Health System, Asheville,  North Carolina,  28801,  United States

      Presbyterian Healthcare, Charlotte,  North Carolina,  28233-3549,  United States

North Dakota
      Dakota Cancer Institute, Fargo,  North Dakota,  58103-4940,  United States

Ohio
      Children's Hospital Medical Center - Cincinnati, Cincinnati,  Ohio,  45229-3039,  United States

      Children's Hospital Medical Center of Akron, Akron,  Ohio,  44308,  United States

      Children's Hospital of Columbus, Columbus,  Ohio,  43205-2696,  United States

      Children's Medical Center - Dayton, Dayton,  Ohio,  45404,  United States

      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195,  United States

      Forum Health-Tod Childrens Hospital, Youngstown,  Ohio,  44501,  United States

      Ireland Cancer Center, Cleveland,  Ohio,  44106-5065,  United States

      St. Vincent Mercy Medical Center, Toledo,  Ohio,  43608,  United States

      Toledo Children's Hospital, Toledo,  Ohio,  43601,  United States

Oklahoma
      CCOP - Oklahoma, Tulsa,  Oklahoma,  74136,  United States

      Children's Hospital of Oklahoma, Oklahoma City,  Oklahoma,  73104,  United States

      Natalie Warren Bryant Cancer Center, Tulsa,  Oklahoma,  74136,  United States

Oregon
      Doernbecher Children's Hospital, Portland,  Oregon,  97201-3098,  United States

      Legacy Emanuel Hospital and Health Center, Portland,  Oregon,  97227,  United States

Pennsylvania
      Children's Hospital of Philadelphia, Philadelphia,  Pennsylvania,  19104,  United States

      Children's Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15213,  United States

      Geisinger Medical Center, Danville,  Pennsylvania,  17822-1320,  United States

      Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033-0850,  United States

      St. Christopher's Hospital for Children, Philadelphia,  Pennsylvania,  19134-1095,  United States

Rhode Island
      Rhode Island Hospital, Providence,  Rhode Island,  02818,  United States

South Carolina
      Children's Hospital of Greenville Hospital System, Greenville,  South Carolina,  29605,  United States

      Medical University of South Carolina, Charleston,  South Carolina,  29425-0721,  United States

      Palmetto Health South Carolina Cancer Center, Columbia,  South Carolina,  29203,  United States

South Dakota
      Avera Cancer Institute, Sioux Falls,  South Dakota,  57105-1080,  United States

      Sioux Valley Hospital, Sioux Falls,  South Dakota,  57117,  United States

Tennessee
      East Tennessee Children's Hospital, Knoxville,  Tennessee,  37901,  United States

      East Tennessee State University Cancer Center at JCMC, Johnson City,  Tennessee,  37604,  United States

      Saint Jude Children's Research Hospital, Memphis,  Tennessee,  38105-2794,  United States

      Vanderbilt-Ingram Cancer Center, Nashville,  Tennessee,  37232-6838,  United States

Texas
      Baylor College of Medicine, Houston,  Texas,  77030,  United States

      Children's Hospital of Austin, Austin,  Texas,  78701,  United States

      Cook Children's Medical Center - Fort Worth, Fort Worth,  Texas,  76104,  United States

      Covenant Children's Hospital, Lubbock,  Texas,  79410,  United States

      Medical City Dallas Hospital, Dallas,  Texas,  75230,  United States

      Methodist Health Care System, San Antonio,  Texas,  78229-3902,  United States

      San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base,  Texas,  78236-5300,  United States

      Scott and White Memorial Hospital, Temple,  Texas,  76508,  United States

      Simmons Cancer Center - Dallas, Dallas,  Texas,  75235-9154,  United States

      Texas Tech University Health Sciences Center School of Medicine, Amarillo,  Texas,  79106,  United States

      University of Texas - MD Anderson Cancer Center, Houston,  Texas,  77030-4009,  United States

      University of Texas Health Science Center at San Antonio, San Antonio,  Texas,  78207,  United States

      University of Texas Medical Branch, Galveston,  Texas,  77555-0361,  United States

Utah
      Huntsman Cancer Institute, Salt Lake City,  Utah,  84112,  United States

Vermont
      Vermont Cancer Center, Burlington,  Vermont,  05401-3498,  United States

Virginia
      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States

      Carilion Medical Center for Children, Roanoke,  Virginia,  24013,  United States

      Children's Hospital of the King's Daughters, Norfolk,  Virginia,  23507,  United States

      Inova Fairfax Hospital, Falls Church,  Virginia,  22042-3300,  United States

      Massey Cancer Center, Richmond,  Virginia,  23298-0037,  United States

      Naval Medical Center, Portsmouth, Portsmouth,  Virginia,  23708-5100,  United States

Washington
      Children's Hospital and Regional Medical Center - Seattle, Seattle,  Washington,  98105,  United States

      Deaconess Medical Center, Spokane,  Washington,  99210-0248,  United States

      Fred Hutchinson Cancer Research Center, Seattle,  Washington,  98109-1024,  United States

      Group Health Cooperative, Seattle,  Washington,  98112,  United States

      Madigan Army Medical Center, Tacoma,  Washington,  98431-5000,  United States

      Mary Bridge Children's Health Center, Tacoma,  Washington,  98415-0299,  United States

West Virginia
      Cabell-Huntington Hospital, Inc, Huntington,  West Virginia,  25701,  United States

      West Virginia University - Charleston, Charleston,  West Virginia,  25302,  United States

      West Virginia University Hospitals, Morgantown,  West Virginia,  26506-9300,  United States

Wisconsin
      Bellin Memorial Hospital, Green Bay,  Wisconsin,  54301,  United States

      CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay,  Wisconsin,  54301,  United States

      Gundersen Lutheran Medical Center, La Crosse,  Wisconsin,  54601,  United States

      Marshfield Clinic, Marshfield,  Wisconsin,  54449-5772,  United States

      Midwest Children's Cancer Center, Milwaukee,  Wisconsin,  53226,  United States

      St. Vincent Hospital, Green Bay,  Wisconsin,  54307-9070,  United States

      University of Wisconsin Hospital and Clinics, Madison,  Wisconsin,  53792-0001,  United States

Australia, New South Wales
      Children's Hospital at Westmead, Westmead,  New South Wales,  2145,  Australia

      Sydney Children's Hospital, Randwick,  New South Wales,  2031,  Australia

Australia, Queensland
      Royal Children's Hospital, Brisbane,  Queensland,  4029,  Australia

Australia, South Australia
      Women's and Children's Hospital, North Adelaide,  South Australia,  5006,  Australia

Australia, Victoria
      Royal Children's Hospital, Parkville,  Victoria,  3052,  Australia

Australia, Western Australia
      Princess Margaret Hospital for Children, Perth,  Western Australia,  6001,  Australia

Canada, Alberta
      Alberta Children's Hospital, Calgary,  Alberta,  T2T 5C7,  Canada

      Cross Cancer Institute, Edmonton,  Alberta,  T6G 1Z2,  Canada

Canada, British Columbia
      British Columbia Children's Hospital, Vancouver,  British Columbia,  V6H 3V4,  Canada

Canada, Manitoba
      CancerCare Manitoba, Winnipeg,  Manitoba,  R3E 0V9,  Canada

Canada, Newfoundland and Labrador
      Janeway Children's Health and Rehabilitation Centre, St. John's,  Newfoundland and Labrador,  A1B 3V6,  Canada

Canada, Nova Scotia
      IWK Health Centre, Halifax,  Nova Scotia,  B3J 3G9,  Canada

Canada, Ontario
      Children's Hospital of Eastern Ontario, Ottawa,  Ontario,  K1H 8L1,  Canada

      Children's Hospital of Western Ontario, London,  Ontario,  N6C 2V5,  Canada

      Children's Hospital, Hamilton,  Ontario,  L8N 3Z5,  Canada

      Hospital for Sick Children, Toronto,  Ontario,  M5G 1X8,  Canada

Canada, Quebec
      Centre Hospitalier de L'Universite Laval, Sainte-Foy,  Quebec,  GIV 4G2,  Canada

      Hopital Sainte Justine, Montreal,  Quebec,  H3T 1C5,  Canada

      Laval University Medical Center, Sainte-Foy,  Quebec,  G1V 4G2,  Canada

      McGill University Health Center - Montreal Children's Hospital, Montreal,  Quebec,  H3H 1P3,  Canada

Canada, Saskatchewan
      Allan Blair Cancer Centre, Regina,  Saskatchewan,  S4T 7T1,  Canada

      Saskatoon Cancer Centre, Saskatoon,  Saskatchewan,  S7N 4H4,  Canada

Netherlands
      Academisch Ziekenhuis Groningen, Groningen,  9700 RB,  Netherlands

New Zealand
      Starship Children's Hospital, Auckland,  New Zealand

Puerto Rico
      San Jorge Childrens Hospital, Santurce,  00912,  Puerto Rico

      University of Puerto Rico School of Medicine Medical Sciences Campus, San Juan,  00936-5067,  Puerto Rico

Switzerland
      Swiss Pediatric Oncology Group Bern, Bern,  CH 3010,  Switzerland

      Swiss Pediatric Oncology Group Geneva, Geneva,  CH 1211,  Switzerland

      Swiss Pediatric Oncology Group Lausanne, Lausanne,  CH 1011,  Switzerland

Study chairs or principal investigators

Daniel M. Green, MD,  Study Chair,  Roswell Park Cancer Institute   

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Study ID Numbers:  CDR0000063900; COG-Q9402; NWTS-Q9402; CCG-4942; POG-9444; INT-0152; NWTS-5/R
Record last reviewed:  April 2003
Last Updated:  October 13, 2004
Record first received:  November 1, 1999
ClinicalTrials.gov Identifier:  NCT00002610
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

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