Clinical Trial: Treatment of AIDS Vacuolar Myelopathy with Methionine

This study has been completed.

Sponsored by: National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by: National Institute of Neurological Disorders and Stroke (NINDS)

Purpose

The purpose of this study is to determine whether methionine, an amino acid present in low doses in the normal diet, can improve myelopathy or stop its progression.

Condition Treatment or Intervention Phase
Myelopathy
AIDS-myelopathy
AIDS vacuolar myelopathy
 Drug: methionine
Phase III

MedlinePlus related topics:  AIDS;   Bone Marrow Diseases;   Spinal Cord Diseases

Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control

Further Study Details: 

Expected Total Enrollment:  56

Myelopathy is usually a late complication of AIDS, and until recently its symptoms were rarely recognized, masked by the general state of disability or the presence of other neurological complications. With prolonged survival and improved quality of life of HIV-infected patients, myelopathy is increasingly becoming a common source of disability. The cause of AIDS-myelopathy is unknown, but it is probably an indirect effect of the long-term presence of the HIV virus in the nervous system rather than the result of a direct infection. The purpose of this study is to determine whether methionine, an amino acid present in low doses in the normal diet, can improve myelopathy or stop its progression.

Eligibility

Ages Eligible for Study:  18 Years   -   80 Years,  Genders Eligible for Study:  Both

Criteria

Between 18 and 80 years of age

Location Information


New York
      Beth Israel Medical Center, New York,  New York,  10003,  United States

Study chairs or principal investigators

Alessandro Di Rocco, MD,  Principal Investigator

More Information

Study ID Numbers:  R01NS35745
Record last reviewed:  March 2004
Last Updated:  October 13, 2004
Record first received:  March 28, 2002
ClinicalTrials.gov Identifier:  NCT00032695
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

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