Clinical Trial: Exposure, Dose, Body Burden and Health Effects of Lead

This study is no longer recruiting patients.

Sponsored by: National Institute of Environmental Health Sciences (NIEHS)
Information provided by: National Institute of Environmental Health Sciences (NIEHS)


This is a study of the effects that lead has on the health of the central nervous system (for example, memory), peripheral nervous system (for example, sensation and strength in the hands and fingers), kidneys, blood pressure, and the blood forming system. A total of 803 lead workers and 135 persons without occupational lead exposure are being studied in South Korea. Lead in the body is being assessed by measurement of blood lead, chelatable lead (an estimate of lead in the tissues), and lead in bone. Subjects are tested three times each over three years. Several genetic factors are also being assessed for the role they play in the health effects of lead. These genes are known to differ among individuals. We are interested to know whether different forms of the same genes can modify the effect lead has on health.

Lead Poisoning

MedlinePlus related topics:  Lead Poisoning

Study Type: Observational
Study Design: Natural History, Longitudinal, Defined Population, Prospective Study

Further Study Details: 

Expected Total Enrollment:  944

Study start: February 1997;  Study completion: February 2002


Ages Eligible for Study:  17 Years   -   70 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers


Lead workers in South Korea in one of 26 specific lead-using facilities.

Population controls in South Korea.

More Information

Study ID Numbers:  7198-CP-001
Record last reviewed:  July 2002
Last Updated:  October 13, 2004
Record first received:  March 29, 2001 Identifier:  NCT00013819
Health Authority: United States: Federal Government processed this record on 2005-04-08

Cache Date: April 9, 2005


  • Lead (Centers for Disease Control and Prevention)
  • Lead (Lab Tests Online)