Osteogenesis Imperfecta Other Information Brittle bone disease; Ekman-Lobstein disease; Fragilitas ossium; OI; Osteopsathyrosis; Vrolik disease
Osteogenesis imperfecta is a group of genetic bone disorders. It is one of the brittle bone diseases. People with OI either have less collagen than normal or the quality is poorer than normal. As collagen is an important protein in bone structure, this impairment causes those with the condition to have weak or fragile bones. As a genetic disorder, OI is an autosomal dominant defect. Most people with OI receive it from a parent but it can also be an individual (de novo or "sporadic") muta ...
Wikipedia - [full article]
From the WEST scientific·clinical
From the EAST traditional·alternative
... Osteogenesis imperfecta (OI) is a skeletal disease characterized by unusually fragile bones that break easily, often under loads that normal bones bear daily. This inherent weakness of the bones is du...
Source: Cleveland Clinic
Questions and Answers about Heritable Disorders of Connective Tissue
... This fact sheet describes a family of more than 200 disorders that affect connective tissues. These disorders result from alterations (mutations) in genes responsible for building tissues. Alterations...
Source: National Institute of Arthritis and Musculoskeletal and Skin Diseases
... Osteogenesis imperfecta is a group of inherited disorders that mainly affect the bones. The term "osteogenesis imperfecta" means imperfect bone formation. The condition causes bones to be fragile and ...
Source: Genetics Home Reference
- Bone Densitometry in Children and Adults with Osteogenesis Imperfecta (National Institute of Arthritis and Musculoskeletal and Skin Diseases)
- Breakthrough: Newsletter of the Osteogenesis Imperfecta Association (Osteogenesis Imperfecta Foundation) - Links to PDF File