Osteoarthritis: Weakness from Inflammation - Article Degenerative Joint Disease; Osteoarthritis arthritis
Clinical Trial: Osteoarthritis: Weakness from Inflammation
This study is currently recruiting patients.
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
MedlinePlus related topics: Osteoarthritis
Study Type: Observational
Study Design: Natural History
Official Title: Weakness from Inflammation: A Basis of Disability from Knee Osteoarthritis
Expected Total Enrollment: 60
Study start: April 2001; Expected completion: March 2006
Through this study, we hope to learn about the natural history of knee osteoarthritis and the disability that arises from it. We hope to better understand why people with knee osteoarthritis develop difficulty with mobility (e.g. walking, standing) in hopes of finding a cure.
There are two visits over a one-week period, and a 2-year follow-up visit. The visits involve a physical exam, a DEXA bone density scan, blood and urine testing, knee x-rays, and electromyography (EMG), and in some cases, a muscle biopsy.
Participation in this study is entirely voluntary.
Ages Eligible for Study: 50 Years and above, Genders Eligible for Study: Both
Accepts Healthy Volunteers
- 50 years of age or older
- A Body Mass Index (BMI) of 30 or less
- Osteoarthritis of the knee (prior to knee surgery) OR
- A healthy knee
- History of a stroke
- History of muscle weakness or paralysis
- History of Rheumatoid Arthritis or
- Inflammatory Joint Disease
- History of a Bleeding Disorder
- History of Gout
- Diabetes for which you take insulin
- Polymyalgia rheumatica (total body muscle aching/stiffness)
Location and Contact Information
Harbor Hospital, Baltimore, Maryland, 21225, United States; Recruiting
Shari Ling, MD, Principal Investigator
Shari Ling, MD, Principal Investigator, NIA, Johns Hopkins Medical Institution Divisions of Rheumatology, Gerontology, and Geriatrics
Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA. Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 2000 May;43(5):995-1000.
Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum. 1998 Nov;41(11):1951-9.
Conwit RA, Stashuk D, Tracy B, McHugh M, Brown WF, Metter EJ. The relationship of motor unit size, firing rate and force. Clin Neurophysiol. 1999 Jul;110(7):1270-5.
Record last reviewed: February 2005
Last Updated: February 24, 2005
Record first received: February 24, 2005
ClinicalTrials.gov Identifier: NCT00104312
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Cache Date: April 9, 2005