Clinical Trial: Effects of Strength Training on Knee Osteoarthritis

This study is no longer recruiting patients.

Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Purpose

To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly with knee pain; and (4) normal elderly with no OA or knee pain. In each of the first three groups, we will look at whether people who do strength training have less pain and/or slower progression of x-ray signs of OA over 30 months than people who perform nonstrengthening, range-of-motion exercises. We are including the fourth group to find out whether people with OA (groups 1 & 2) have the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain.

Condition Treatment or Intervention Phase
Osteoarthritis, Knee
 Procedure: Progressive resistance exercise
Phase II

MedlinePlus related topics:  Osteoarthritis

Study Type: Interventional
Study Design: Treatment, Randomized, Single Blind, Active Control, Single Group Assignment, Efficacy Study

Official Title: Effects of Strength Training on Knee Osteoarthritis (OA)

Further Study Details: 

Expected Total Enrollment:  280

Study start: September 1977;  Study completion: March 2001

Several studies have confirmed that weak leg muscles are associated with osteoarthritis (OA) of the knee. Studies of body composition in these people have also shown that, despite being weaker, people with OA have significantly greater muscle mass than those without OA, suggesting that those with OA may have the potential to greatly increase their strength. However, research has not clearly shown whether exercises designed to improve leg strength will decrease the severity of pain or slow the progression of OA based on radiographic (x-ray) analysis. To understand the effects of leg strengthening exercise, we will perform a randomized clinical trial of lower extremity strength training using four subgroups of people: (1) OA with knee pain; (2) OA without knee pain; (3) no OA with knee pain; and (4) normal elderly with no OA or knee pain.

In each of the first three groups, we will determine whether people assigned to strength training have lower pain scores and/or slower progression of radiographic changes of OA over 30 months than controls who perform nonstrengthening exercises (i.e., range-of-motion exercises). We are including the fourth group to determine whether those with OA (groups 1 & 2) exhibit the same response to strength training as healthy elderly people, and whether those with knee pain (groups 1 & 3) have the same response to training as those without joint pain. We will also prospectively monitor changes in body composition and bone mass, quality of life, and symptoms of depression.

Eligibility

Ages Eligible for Study:  60 Years and above,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

  • Males and females 60 to 100 years of age

Exclusion Criteria:

  • Knee joint replacement surgery
  • Diabetes mellitus
  • Uncontrollable hypertension
  • Neuropathies of the lower extremity
  • Poor mental cognition (i.e., inability to follow instructions)

Location Information


Indiana
      National Institute for Fitness and Sport, Indianapolis,  Indiana,  46202,  United States

Study chairs or principal investigators

Alan Mikesky, PhD,  Principal Investigator,  Indiana University School of Medicine   

More Information

Study ID Numbers:  NIAMS-022; P60 AR20582; Sub: EEHSR3
Record last reviewed:  February 2004
Last Updated:  October 13, 2004
Record first received:  November 3, 1999
ClinicalTrials.gov Identifier:  NCT00000406
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

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