Clinical Trial: Combination Chemotherapy Plus Peripheral Stem Cell Transplantation With or Without Rituximab in Treating Patients With Relapsed Non-Hodgkin's Lymphoma

This study is currently recruiting patients.

Sponsors and Collaborators: EBMT Solid Tumors Working Party
British National Lymphoma Investigation
Information provided by: National Cancer Institute (NCI)

Purpose

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. It is not yet known if combination chemotherapy plus peripheral stem cell transplantation is more effective with or without rituximab for non-Hodgkin's lymphoma.

PURPOSE: This randomized phase III trial is studying giving combination chemotherapy and peripheral stem cell transplantation together with rituximab to see how well it works compared to combination chemotherapy and peripheral stem cell transplantation alone in treating patients with relapsed non-Hodgkin's lymphoma.

Condition Treatment or Intervention Phase
recurrent grade 1 follicular lymphoma
recurrent grade 2 follicular lymphoma
recurrent grade 3 follicular lymphoma
 Drug: carmustine
 Drug: cyclophosphamide
 Drug: cytarabine
 Drug: etoposide
 Drug: filgrastim
 Drug: melphalan
 Drug: rituximab
 Procedure: antibody therapy
 Procedure: biological response modifier therapy
 Procedure: bone marrow ablation with stem cell support
 Procedure: chemotherapy
 Procedure: colony-stimulating factor therapy
 Procedure: cytokine therapy
 Procedure: high-dose chemotherapy
 Procedure: monoclonal antibody therapy
 Procedure: peripheral blood stem cell transplantation
Phase III

MedlinePlus related topics:  Cancer;   Cancer Alternative Therapy;   Lymphatic Diseases;   Lymphoma

Study Type: Interventional
Study Design: Treatment

Official Title: Phase III Randomized Study of Rituximab Purging and Maintenance With Peripheral Blood Stem Cell Transplantation in Patients With Relapsed or Resistant Follicular Non-Hodgkin's Lymphoma Undergoing High-Dose Chemotherapy

Further Study Details: 

OBJECTIVES:

OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to type of remission (complete vs good partial) and which remission (second vs third). Patients are randomized to one of four treatment arms.

All patients receive induction chemotherapy comprising cyclophosphamide IV over 3-4 hours on day 0 or a standard induction chemotherapy regimen. Filgrastim (G-CSF) is administered subcutaneously daily beginning on day 1.

Patients are then randomized to receive either in vivo rituximab purging or no purging following restaging after completion of induction. For those patients receiving purging (arms I and II), rituximab is administered IV once weekly for 4 weeks.

Peripheral blood stem cells (PBSC) are collected between days 8 and 12 post induction chemotherapy. Within 4 weeks of PBSC collection, patients receive carmustine IV over 2 hours on day -6, etoposide IV over 2 hours on days -5 to -2, cytarabine IV over 5 minutes twice daily on days -5 to -2, and melphalan IV over 10-15 minutes on day -1. (Alternatively, high dose cyclophosphamide and total body irradiation beginning 2-4 weeks after cyclophosphamide or standard induction chemotherapy priming is also allowed.) PBSC are reinfused on day 0.

Patients are further randomized to receive either rituximab maintenance or observation only. For those patients receiving maintenance (arms I and III), rituximab is administered IV once every 2 months for 4 doses beginning 30 days after PBSC reinfusion.

Patients are followed at 30 days, 3, 6, 9, and 12 months after PBSC transplant, every 6 months for 2 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 460 patients (115 per treatment arm) will be accrued for this study within 5 years.

Eligibility

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

PATIENT CHARACTERISTICS: Age:

  • 18 and over

Performance status:

  • WHO 0-1

Life expectancy:

  • Not specified

Hematopoietic:

  • See Disease Characteristics

Hepatic:

  • Bilirubin normal
  • ALT no greater than 2 times upper limit of normal (ULN)
  • Alkaline phosphatase no greater than 2 times ULN
  • Hepatitis B negative
  • Hepatitis C negative

Renal:

  • Creatinine no greater than 2 times ULN
  • BUN no greater than 2 times ULN

Cardiovascular:

Pulmonary:

Other:

  • Not pregnant or nursing
  • HIV negative
  • No other uncontrolled serious medical conditions
  • No other malignancy within the past 5 years except nonmelanoma skin tumors or carcinoma in situ of the cervix

PRIOR CONCURRENT THERAPY: Biologic therapy:

Chemotherapy:

  • See Disease Characteristics
  • No more than 3 prior chemotherapy regimens for NHL

Endocrine therapy:

  • Not specified

Radiotherapy:

Surgery:

  • Not specified

Location and Contact Information


Australia, New South Wales
      Sydney Cancer Centre at Royal Prince Alfred Hospital, Sydney,  New South Wales,  2050,  Australia; Recruiting
John Gibson, MD  61-2-9515-8031    jgibson@haem.rpa.cs.nsw.gov.au 

      Westmead Hospital, Westmead,  New South Wales,  2145,  Australia; Recruiting
K. Bradstock, MB, BS, PhD, FRACP  61-2-9845-7073    bradstok@icpmr.wsahs.nsw.gov.au 

Australia, Queensland
      Royal Brisbane and Women's Hospital, Brisbane,  Queensland,  4029,  Australia; Recruiting
Simon Durrant, MD  61-7-3636-8756    simon_durrant@health.qld.gov.au 

Australia, South Australia
      Queen Elizabeth Hospital, Woodville,  South Australia,  5011,  Australia; Recruiting
John E. Norman, MD  61-8-222-6645    john.norman@nwahs.sa.gov.au 

      Royal Adelaide Hospital Cancer Centre, Adelaide,  South Australia,  5000,  Australia; Recruiting
Bik To, MD  61-8-8222-3262    bik.to@imvs.sa.gov.au 

Australia, Victoria
      Royal Melbourne Hospital, Parkville,  Victoria,  3050,  Australia; Recruiting
Jeffrey Szer, MD  61-3-9342-7737    jeff.szer@mh.org.au 

Australia, Western Australia
      Fremantle Hospital, Fremantle,  Western Australia,  6160,  Australia; Recruiting
Michael Leahy, MBChB, FRACP, FRCP, FRC Path  61-8-9431-2886 

      Royal Perth Hospital, Perth,  Western Australia,  6000,  Australia; Recruiting
Richard Herrmann, MD  61-8-9224-2405    richard.herrmann@health.wa.gov.au 

Austria
      Allgemeines Krankenhaus der Stadt Wien, Vienna,  A-1090,  Austria; Recruiting
Hildegard T. Greinix, MD  43-1-4040-04457    hildegard.greinix@meduniwier.ac.at 

Belgium
      Academisch Ziekenhuis der Vrije Universiteit Brussel, Brussels,  1090,  Belgium; Recruiting
Rik Schots, MD, PhD  32-2-477-6211    rik.schots@az.vub.ac.be 

      CHU Liege - Domaine Universitaire du Sart Tilman, LIEGE,  B-4000,  Belgium; Recruiting
Yves Beguin, MD  43-66-76-90    yves.beguin@chu.ulg.ac.be 

      Clinique Sainte Elisabeth, Namur,  5000,  Belgium; Recruiting
L. Van Den Bossche  32-81-720-411 

      Clinique Universitaire De Mont-Godinne, Mont-Godinne Yvoir,  5530,  Belgium; Recruiting
Andre Bosly, MD, PhD  32-81-423831    andre.bosly@sang.ucl.ac.be 

      H. Hartziekenhuis V.Z.W., Roeselare,  8800,  Belgium; Recruiting
Filip J.J.C. Van Aelst, MD  32-51-237-111    fvanaelst@hhr.be 

      Institut Jules Bordet, Brussels,  1000,  Belgium; Recruiting
Dominique Bron, MD  32-2-541-3232    dbron@ulb.ac.be 

      U.Z. Gasthuisberg, Leuven,  B-3000,  Belgium; Recruiting
Peter Vandenberghe, MD, PhD  32-16-345-903 

      Universitair Ziekenhuis Gent, Ghent,  B-9000,  Belgium; Recruiting
Fritz Offner, MD  32-92-40-21-25    fritz.offner@rug.ac.be 

      Ziekenhuis Network Antwerpen Middelheim, Antwerpen,  B-2020,  Belgium; Recruiting
Robrecht De Bock, MD  32-3-280-3484    robrecht.debock@zna.be 

Canada, Alberta
      Tom Baker Cancer Centre - Calgary, Calgary,  Alberta,  T2N 4N2,  Canada; Recruiting
Douglas A. Stewart, MD  403-944-1761 

Canada, Ontario
      Ottawa Regional Cancer Centre at Ottawa Hospital - General Campus, Ottawa,  Ontario,  K1H 8L6,  Canada; Recruiting
Isabelle Bence-Bruckler  613-737-8443 

Czech Republic
      University Hospital Kralovske Vinohr, Prague 10,  10034,  Czech Republic; Recruiting
T. Kozak, MD, PhD  420-2-6716-2292    kozak@fnkv.cz 

Denmark
      Herlev Hospital - University Hospital of Copenhagen, Copenhagen,  DK-2730,  Denmark; Recruiting
Hans Erik Johnsen, MD  45-44-88-39-05    haej@herlevhosp.kbhamt.dk 

      Odense University Hospital, Odense,  DK-5000,  Denmark; Recruiting
B. E. Christensen  45-65-412-923 

      Rigshospitalet, Copenhagen,  2100,  Denmark; Recruiting
Christian Geisler  45-3545-4286 

France
      Centre Henri Becquerel, Rouen,  76038,  France; Recruiting
Herve Tilly, MD  33-2-3208-2223    hertil@rouen.fnclcc.fr 

      Centre Hospitalier Lyon Sud, Pierre-Benite,  69495,  France; Recruiting
Gilles Andre Salles, MD, PhD  33-478-861-191    gilles.galles@chu-lyon.fr 

      Centre Hospitalier Regional et Universitaire d'Angers, Angers,  49033,  France; Recruiting
M. Gardembas, MD  33-02-41-354-705 

      Centre Hospitalier Universitaire Bretonneau de Tours, Tours,  37044,  France; Recruiting
Philippe H. Colombat, MD  33-2-47-47-37-12 

      Centre Leon Berard, Lyon,  69373,  France; Recruiting
Catherine Sebban, MD  33-04-78-782-645 

      Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle, Montpellier,  34298,  France; Recruiting
Michel Fabbro, MD  04-67-61-30-63    mfabbro@valdorel.fnclcc.fr 

      Centre Regional Francois Baclesse, Caen,  14076,  France; Recruiting
A. M. Peny, MD  33-2-31-45-50-50 

      CHR Hotel Dieu, Nantes,  44093,  France; Recruiting
Noel Milpied  33-24-008-3272 

      CHU de Grenoble - Hopital de la Tronche, Grenoble,  38043,  France; Recruiting
Remy Gressin, MD  33-4-7676-5712    RGressin@chu-grenoble.fr 

      CHU Pitie-Salpetriere, Paris,  75651,  France; Recruiting
Jean Gabarre, MD  33-1-42-169-792    jean.gabarre@psl.ap_hop_paris.fr 

      CHU Rennes - Hopital Pontchaillou, Rennes,  35033,  France; Recruiting
Thiery Lamy, MD, PhD  33-2-99-28-42-91    thierry.lamy@univ-rennes1.fr 

      Hopital Saint-Louis, Paris,  75475,  France; Recruiting
Christian Gisselbrecht, MD  33-1-4249-9296 

      Institut Gustave Roussy, Villejuif,  F-94805,  France; Recruiting
Jean-Henri Bourhis, MD, PhD  33-1-42-11-4507    jhb@igr.fr 

      Polyclinique Du Parc, Caen,  14052,  France; Recruiting
Levatien, MD  33-2-31-82-82-82 

      Polyclinique Saint Jean, Melun,  77000,  France; Recruiting
C. Kulecki, MD  33-1-64-14-30-00 

Germany
      Eberhard Karls Universitaet, Tuebingen,  D-72076,  Germany; Recruiting
Ch. Faul, MD  49-7071-29-84087 

      Ev. Diakome Krankenhaus gGmBH, Bremen,  28239,  Germany; Recruiting
Karl-Heinz Pflueger, MD  011-49-421-6102-1481    pfluegerkh@diako-bremen.de 

      Klinikum Nuernberg - Klinikum Nord, Nuernberg,  D-90419,  Germany; Recruiting
Hannes Wandt, MD  49-911-398-3060    wandt@klinikum-nuernberg.de 

      Klinikum Oldenburg, Oldenburg,  D-26133,  Germany; Recruiting
B. Metzner, MD  494-414-032-614    metzner.bernd@klinikum-oldenburg.de 

      Marienhospital / Ruhr University Bochum, Herne,  D-44625,  Germany; Recruiting
U. Graeven, MD  49-2323-499-1661 

      Medical University Hospital Homburg, Homburg,  66421,  Germany; Recruiting
L. Truemper, MD  49-68-41-160 

      Saint Georg-Hospital, Hamburg,  D-20099,  Germany; Recruiting
Norbert Schmitz, MD, PhD  49-40-2890-2005    Norbert.Schmitz@ak-stgeorg.lbk.hh.de 

      Universitaetsklinikum Goettingen, GOETTINGEN,  D-37075,  Germany; Recruiting
W. Jung, MD  49-551-396-210 

      Universitatsklinik - Saarland, Homburg,  D-66421,  Germany; Recruiting
F. Hartmannn  49-6841-162-3000    infhar@uniklinik-saarland.de 

      Zentralklinikum Augsburg, Augsburg,  DOH-86156,  Germany; Recruiting
Contact Person  49-821-400-2353 

      Zentralkrankenhaus, Bremen,  D-28205,  Germany; Recruiting
C. Richard Meier, MD  49-421-497-2000 

Israel
      Chaim Sheba Medical Center, Tel Hashomer,  52621,  Israel; Recruiting
Arnon Nagler, MD  972-3-530-5830    a.nagler@sheba.health.gov.il 

New Zealand
      Auckland Hospital, Auckland,  1,  New Zealand; Recruiting
T. Hawkins, MD  64-9-307-5499 

      Canterbury Health Laboratories, Christchurch,  New Zealand; Recruiting
W. N. Patton, MD  64-3-364-0300    nigel.patton@cdhb.govt.nz 

      Waikato Hospital, Hamilton,  2020,  New Zealand; Recruiting
Michael Jameson, MD  64-7-839-8604 

Poland
      K. Dluski Hospital-Medical Academy, Wroclaw,  53 439,  Poland; Recruiting
A. Lange, MD  48-71-621-512 

      Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw,  02-781,  Poland; Recruiting
Jan Walewski, MD  48-22-546-2223    walewski@coi.waw.pl 

Portugal
      Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, S.A., Lisboa,  1099-023 Codex,  Portugal; Recruiting
F. Leal Da Costa, MD  351-21-722-9800 

Spain
      Centro Medico Teknon, Barcelona,  08022,  Spain; Recruiting
P. Vivancos, MD  34-93-290-62-00 

      Complexo Hospitalario Xeral de Vigo, Vigo Pontevedra,  36204,  Spain; Recruiting
C. A. Lopez, MD  34-986-816-000 

      Hospital Clinic de Barcelona, Barcelona,  08036,  Spain; Recruiting
Armando Lopez Guillermo, MD  34-93-227-5575    alopezg@clinic.ub.es 

      Hospital Clinico Universitario de Valencia, Valencia,  46010,  Spain; Recruiting
Javier Garcia-Conde, MD  34-96-386-2625    garciaco@uv.es 

      Hospital Clinico Universitario Lozano Blesa, Zaragoza,  50006,  Spain; Recruiting
Martin M. Gutierrez, MD, PhD  34-976-350-418    marting@unizar.es 

      Hospital Cuidad de Jaen, Jaen,  E-23006,  Spain; Recruiting
Mufioz Alcala  34-953-299-029 

      Hospital de Cruces, Barakaldo Bilbao,  E-48903,  Spain; Recruiting
J. C. Garcia-Ruiz, MD  34-94-600-6000    jcgarcia@hcru.osalxidetza.net 

      Hospital de Galdakao, Galdakao-Vizcaya,  48000,  Spain; Recruiting
J. M. Ojanguen  34-94-400-6000 

      Hospital de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria,  350311,  Spain; Recruiting
Adsuar C. Campo  34-928-450-001 

      Hospital de la Princesa, Madrid,  28006,  Spain; Recruiting
Reyes Arranz Saez, MD, PhD  34-91-520-2200 

      Hospital de la Santa Cruz I Sant Pau, Barcelona,  08025,  Spain; Recruiting
J. Sierra, MD  34-93-291-9396    jsierra@hsp.santpau.es 

      Hospital General - Alicante, Alicante,  3010,  Spain; Recruiting
F. A. Pascual  34-965-938-300 

      Hospital General de Castellon, Castellon,  12004,  Spain; Recruiting
R. Garcia Boyero  34-964-211-000 

      Hospital General Universitario "Morales Meseguer", Murcia,  30008,  Spain; Recruiting
Jose M. Moraleda, MD  34-968-360-900 

      Hospital General Universitario Gregorio Maranon, Madrid,  28007,  Spain; Recruiting
Jose L. Diez-Martin, MD, PhD  34-91-5868000    jdiez.hgugm@salud.madrid.org 

      Hospital Juan Canalejo, La Coruna,  15000,  Spain; Recruiting
Gomez R. Varela  34-981-178-000 

      Hospital Mutua de Terrassa, Terrassa,  08221,  Spain; Recruiting
Cristina Estany, MD  34-93-736-5050 

      Hospital Ramon y Cajal, Madrid,  28034,  Spain; Recruiting
D. J. Garcia-Larana, MD  34-91-336-8263 

      Hospital San Pedro de Alcantara, Caceres,  10000,  Spain; Recruiting
Martin M. Paz  34-927-256-200 

      Hospital Son Dureta, Palma de Mallorca,  07014,  Spain; Recruiting
A. Novo Garcia, MD  34-971-175-000 ext. 75934    anovo@aehh.org 

      Hospital Universidad Virgen Del Rocio, Sevilla,  E- 41013,  Spain; Recruiting
R. Parody Ruisberdejo, MD  34-95-424-8181 

      Hospital Universitari Germans Trias i Pujol, Barcelona,  08916,  Spain; Recruiting
J. M. Ribera Santasusana, MD, PhD  34-93-497-8987    jmribera@ns.hugtip.scs.ep 

      Hospital Universitario 12 de Octubre, Madrid,  28041,  Spain; Recruiting
J.J. Lahuerta, MD, PhD  3491-3908525    jjlauerta@terra.es 

      Hospital Universitario Central de Asturias, Oviedo,  33006,  Spain; Recruiting
D. Carrera Fernandez  34-98-510-6100 

      Hospital Universitario de Getafe, Madrid,  28905,  Spain; Recruiting
J. A. Garcia, MD  34-91-683-9360 

      Hospital Universitario Marques de Valdecilla, Santander,  39008,  Spain; Recruiting
E. Conde, MD  34-942-203-450 

      Hospital Universitario Miguel Servet, Zaragoza,  50009,  Spain; Recruiting
D. R. Felix  34-976-765-500 

      Hospital Universitario Puerta Del Mar, Cadiz,  11000,  Spain; Recruiting
F. J. Capote, MD  34-956-242-100 

      Hospital Universitario San Carlos, Madrid,  28040,  Spain; Recruiting
A. Alvarez-Carmona  34-91-330-3000 

      Hospital Virgen de la Arrixaca, El Palmar,  30120,  Spain; Recruiting
A. Morales, MD  34-968-36-95-00    alfonso.morales@carm.es 

      Hospital Virgen de la Vega, Salamanca,  37007,  Spain; Recruiting
M. Gonzalez  34-923-291-200 

      Hospital Virgen de las Nieves, Granada,  18014,  Spain; Recruiting
A. Romero Aguilar  34-958-020-073 

      Unidad De Oncol/Hemat. Hospital, Valencia,  46017,  Spain; Recruiting
S. Ferrer Bordes, MD  34-96-386-2500 

      University Hospital - Salamanca, Salamanca,  37007,  Spain; Recruiting
D. Caballero, MD  34-923-291-316    cabarri@usal.es 

Sweden
      Karolinska University Hospital - Huddinge, Stockholm,  SE-141 86,  Sweden; Recruiting
Eva K. Kimby, MD, PhD  46-8-746-1000    eva.kimby@swipnet.se 

Switzerland
      Kantonsspital Bruderholz, Bruderholz,  CH-4101,  Switzerland; Recruiting
Lorenz M. Jost, MD  41-61-436-3636    lorenz.jost@ksbh.ch 

      UniversitaetsSpital, Zurich,  CH-8091,  Switzerland; Recruiting
Christian Taverna, MD  41-1-255-2214    christian.taverna@usz.ch 

Turkey
      Ibn-i Sina Hospital, Ankara,  06100,  Turkey; Recruiting
M. Ozcan, MD  90-312-310-3333 Ext. 2121    azcan@medicine.ankara.edu.tr 

United Kingdom, England
      Birmingham Heartlands and Solihull NHS Trust -Teaching, Birmingham,  England,  B9 5SS,  United Kingdom; Recruiting
D.W. Milligan, MD  44-0121-424-2000 ext. 43703 an    d.w.milligan@bham.ac.uk 

      Bristol Haematology and Oncology Centre, Bristol,  England,  BS2 8ED,  United Kingdom; Recruiting
R. Evely, MD  44-117-923-0000 

      Cancer Research Centre at Weston Park Hospital, Sheffield,  England,  S1O 2SJ,  United Kingdom; Recruiting
Linda Evans, MD  44-114-226-5000 

      Great Western Hospital, Swindon,  England,  SN3 6BB,  United Kingdom; Recruiting
Norbert E. Blesing, MD  44-1793-605-004    neblesing@hotmail.com 

      Guy's and St. Thomas' Hospitals NHS Foundation Trust, London,  England,  SE1 9RT,  United Kingdom; Recruiting
Stephen Schey, MD  44-20-795-55-000 

      Hillingdon Hospital, Uxbridge,  England,  UB8 3NN,  United Kingdom; Recruiting
R. Kaczmarski, MD  44-1-895-238-282 

      Huddersfield Royal Infirmary, Huddersfield, West Yorks,  England,  HD3 3EA,  United Kingdom; Recruiting
Contact Person  44-1484-342-000 

      Hull Royal Infirmary, Hull,  England,  HU3 2KZ,  United Kingdom; Recruiting
R. Patmore, MD  44-014-8232-8541 

      James Paget Hospital, Norfolk,  England,  NR31 6LA,  United Kingdom; Recruiting
Shalal Sadullah, MD  44-01-493-452-827    shalal.sadullah@jiaget.nhs.uk 

      Kettering General Hosptial, Kettering, Northants,  England,  NNI6 8UZ,  United Kingdom; Recruiting
M. Lyttelton, MD  536-492-699    matthew.lyttelton@kgh.nks.uk 

      Leeds General Infirmary at Leeds Teaching Hospital NHS Trust, Leeds,  England,  LS1 3EX,  United Kingdom; Recruiting
J. A. Child, MD  44-113-392- 5153    tony.child@leedsth.nhs.uk 

      Leicester Royal Infirmary, Leicester,  England,  LE1 5WW,  United Kingdom; Recruiting
A. Hunter, MD  0116-258-6602    ann.hunter@uhl-tr.nhs.uk 

      Liverpool University Hospital, Liverpool,  England,  L9 7AL,  United Kingdom; Recruiting
A R Petitt, MD  44-151-706-43-63 

      Norfolk and Norwich University Hospital, Norwich,  England,  NR4 7UY,  United Kingdom; Recruiting
M. Deane, MD  44-603-286-286 

      Nottingham City Hospital NHS Trust, Nottingham,  England,  NG5 1PB,  United Kingdom; Recruiting
A. McMillan  44-115-969-1169 

      Oxford Radcliffe Hospital, Oxford,  England,  0X3 9DU,  United Kingdom; Recruiting
C. Hatton, MD  44-186-522-1387    chris.hatton@orh.nhs.uk 

      Pontefract General Infirmary, Pontefract West Yorkshire,  England,  WF8 1PL,  United Kingdom; Recruiting
D. Wright, MD  44-1977-600-600 

      Princess Margaret Hospital, Swindon,  England,  SN3 6BB,  United Kingdom; Recruiting
Norbert E. Blesing, MD  44-1793-605-004    neblesing@hotmail.com 

      Rotherham District General Hospital - NHS Trust, Rotherham,  England,  S60 2UD,  United Kingdom; Recruiting
Helen Barker, MD  44-1709-820-000 

      Royal Bournemouth Hospital, Bournemouth,  England,  BH7 7DW,  United Kingdom; Recruiting
S. Killick  44-1202-303-626 

      Royal Devon and Exeter Hospital, Exeter,  England,  EX2 5DW,  United Kingdom; Recruiting
M. V. Joyner, MD  44-1392-402-928 

      Royal Liverpool and Broadgreen Hospitals, Liverpool,  England,  L7 8XP,  United Kingdom; Recruiting
A. R. Pettit, MD  44-151-706-4363 

      Royal Marsden NHS Foundation Trust - Surrey, Sutton,  England,  SM2 5PT,  United Kingdom; Recruiting
Gareth J. Morgan, MD  44-20-8661-3117 

      Royal United Hospital, Bath,  England,  BA1 3NG,  United Kingdom; Recruiting
C. J.C. Knechtli, MB, ChB, PhD, FRCP, MRCPath  44-1225-824-704 

      Saint Bartholomew's Hospital, London,  England,  EC1A 7BE,  United Kingdom; Recruiting
Thomas Andrew Lister, MD, FRCP, FRCPath  44-20-7601-7462    andrew.lister@cancer.org.uk 

      Sandwell General Hospital, West Bromwich,  England,  B71 4HJ,  United Kingdom; Recruiting
Penny J. Stableforth, MD  44-121-553-1831 

      Southampton General Hospital, Southampton,  England,  SO16 6YD,  United Kingdom; Recruiting
Peter Johnson, MD  44-23-8079-6185    johnsonp@soton.ac.uk 

      St. Georges Hospital Medical School, London,  England,  SW17 ORE,  United Kingdom; Recruiting
Ruth Pettengell, MD  44-20-8725-5454    r.petteng@sghms.ac.uk 

      Staffordshire General Hospital, Stafford,  England,  ST16 3SA,  United Kingdom; Recruiting
Paul Revell, MD  44-1785-257-731    jayne.anslow@msgh-tr.wmids.nhs.uk 

      Stoke Mandeville Hospital, Aylesbury-Buckinghamshire,  England,  HP21 8AL,  United Kingdom; Recruiting
A.M. O'Hea, MD  44-1-296-315-000 

      University College Hospital, London,  England,  WC1E 6AU,  United Kingdom; Recruiting
Antony H. Goldstone, FRCP  44-20-7380-9678    anthony.golstone@uclh.org 

      University College London Medical School, London,  England,  WC1E 6HX,  United Kingdom; Recruiting
David C. Linch  44-171-380-9724 

United Kingdom, Northern Ireland
      Belfast City Hospital Trust, Belfast,  Northern Ireland,  BT9 7AB,  United Kingdom; Recruiting
R.J.G. Cuthbert, MD, FRCP, FRCPath  44-0-28-9032-9241    robert.cuthbert@bll.n.i.nhs.uk 

United Kingdom, Scotland
      Aberdeen Royal Infirmary, Aberdeen,  Scotland,  AB25 2ZN,  United Kingdom; Recruiting
Dominic J. Culligan, MD  44-1224-553-394    dominic.culligan@arh.grampian.scot.nhs.uk 

      Pinderfields Hospital NHS Trust, Wakefield,  Scotland,  WF1 4DG,  United Kingdom; Recruiting
P. Hillmen, MD  44-192-420-1688    peter.hillmen@panp-tr.northy.nhs.uk 

      Royal Infirmary - Castle, Glasgow,  Scotland,  G4 0SF,  United Kingdom; Recruiting
Grant Mcquaker, MD  44-141-211-1160 

      Western General Hospital, Edinburgh,  Scotland,  EH4 2XU,  United Kingdom; Recruiting
Michael Mackie, MD  44-131-537-1903    mike.mackie@luht.scot.nhs.uk 

United Kingdom, Wales
      Prince Philip Hospital, Dyfed,  Wales,  SA14 8QF,  United Kingdom; Recruiting
S. Lewis, MD  44-1554-756-567 

      Singleton Hospital, Swansea,  Wales,  SA 2 8QA,  United Kingdom; Recruiting
Saad Al-Ismail, MD  44-1792-285-024    saad.al-ismail@swansea-tr.wales.nhs.uk 

      Ysbyty Gwynedd, Bangor,  Wales,  LL57 2PW,  United Kingdom; Recruiting
H. Parry, MD  44-1248-384-384 Ext. 4369 

Study chairs or principal investigators

Ruth Pettengell, MD,  Study Chair,  St. Georges Hospital Medical School   
David C. Linch,  Study Chair,  University College London Medical School   

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Study ID Numbers:  CDR0000067665; EBMT-EBMTLYM1; BNLI-EBMT-EBMTLYM1; EU-99050; NCT00005589
Record last reviewed:  September 2003
Last Updated:  March 28, 2005
Record first received:  May 2, 2000
ClinicalTrials.gov Identifier:  NCT00005589
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005