Clinical Trial: Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children with Newly Diagnosed Hodgkin's Disease

This study is currently recruiting patients.

Sponsors and Collaborators: Children's Oncology Group
National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)


RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more cancer cells. Radiation therapy uses high-energy x-rays to damage cancer cells. It is not yet known if chemotherapy is more effective with or without additional chemotherapy and/or radiation therapy in treating Hodgkin's disease.

PURPOSE: This randomized phase III trial is studying different chemotherapy regimens given with or without radiation therapy to compare how well they work in treating children with newly diagnosed Hodgkin's disease.

Condition Treatment or Intervention Phase
childhood Hodgkin's lymphoma
 Drug: bleomycin
 Drug: cisplatin
 Drug: cyclophosphamide
 Drug: cytarabine
 Drug: dexamethasone
 Drug: doxorubicin
 Drug: etoposide
 Drug: filgrastim
 Drug: prednisone
 Drug: vincristine
 Procedure: biological response modifier therapy
 Procedure: chemotherapy
 Procedure: colony-stimulating factor therapy
 Procedure: cytokine therapy
 Procedure: radiation therapy
Phase III

MedlinePlus related topics:  Hodgkin's Disease

Study Type: Interventional
Study Design: Treatment

Official Title: Phase III Randomized Study of Response-Based Chemotherapy With Doxorubicin, Bleomycin, Vincristine, Etoposide, Prednisone, and Cyclophosphamide With or Without Dexamethasone, Etoposide, Cytarabine, Cisplatin, and/or Radiotherapy in Children With Newly Diagnosed Intermediate-Risk Hodgkin's Lymphoma

Further Study Details: 


  • Compare response-based therapy with doxorubicin, bleomycin, vincristine, etoposide, prednisone, and cyclophosphamide with or without dexamethasone, etoposide, cytarabine, cisplatin, and/or radiotherapy in children with intermediate-risk Hodgkin's lymphoma.
  • Determine whether radiotherapy can be eliminated from this regimen based upon early and complete response to multiagent chemotherapy in these patients.
  • Determine whether the addition of dexamethasone, etoposide, cytarabine, cisplatin, and filgrastim (G-CSF) improves outcome in those patients with a slow early response to standard chemotherapy.
  • Compare the frequency and severity of late effects of this therapy, including thyroid dysfunction, infertility, cardiotoxicity, pulmonary toxicity, and second malignant neoplasms, in patients treated with these regimens.
  • Correlate results from biology and late effects studies with response to therapy, event-free survival, and overall survival in these patients.

OUTLINE: This is a randomized, multicenter study.

  • Patients receive doxorubicin IV over 10-30 minutes on days 1-2, bleomycin IV over 10-20 minutes or subcutaneously (SC) and vincristine IV on days 1 and 8, etoposide IV over 1 hour on days 1-3, oral prednisone 2 or 3 times daily on days 1-7, and cyclophosphamide IV over 1 hour on day 1. Patients receive filgrastim (G-CSF) SC beginning on day 4 and continuing until blood counts recover (G-CSF is held on day 8). Treatment repeats every 21 days for 2 courses in the absence of progressive disease. At the end of initial chemotherapy, patients undergo evaluation for response. Patients with less than 60% disease reduction are considered to have slow early response (SER). Patients with 60% or more disease reduction are considered to have rapid early response (RER).
  • RER: Patients with RER receive 2 additional courses of ABVE-PC chemotherapy. After the additional course, patients with less than a complete response undergo radiotherapy 5 days a week. Patients with a complete response are randomized to receive either radiotherapy or no further treatment.
  • Patients with SER are randomized to 1 of 2 treatment arms.
  • Arm I: Patients receive dexamethasone IV over 15 minutes, etoposide IV over 3 hours, and cytarabine IV over 3 hours on days 1-2 and cisplatin IV over 6 hours on day 1. Patients also receive G-CSF SC beginning on day 3 and continuing until blood counts recover. Treatment repeats every 21 days for 2 courses in the absence of disease progression or unacceptable toxicity. After these 2 courses, patients then receive 2 additional courses of ABVE-PC chemotherapy. Patients then undergo radiotherapy.
  • Arm II: Patients receive 2 additional courses of ABVE-PC chemotherapy. Patients then undergo radiotherapy. Patients are followed every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 1,000 patients will be accrued for this study within 5-5.5 years.


Ages Eligible for Study:  up to  21 Years,  Genders Eligible for Study:  Both



  • Histologically confirmed newly diagnosed Hodgkin's lymphoma
  • All histologies eligible
  • Stage IB or IIB
  • Stage IA with bulk disease
  • Stage IIA with bulk disease
  • Stage IIAE
  • Stage IIIA
  • Stage IVA
  • May not be staged by laparotomy alone
  • Surgically staged patients must also have presurgical staging


  • 21 and under

Performance status:

  • Not specified

Life expectancy:

  • Not specified


  • Not specified


  • Bilirubin no greater than 1.5 times normal
  • SGOT or SGPT less than 2.5 times normal


  • Creatinine no greater than 1.5 times normal
  • Creatinine clearance greater than 40 mL/min OR
  • Radioisotope glomerular filtration rate greater than 70 mL/min


  • Shortening fraction at least 27% by echocardiogram OR
  • Ejection fraction at least 50% by MUGA
  • No pathologic prolongation of QTc interval on 12-lead electrocardiogram


  • FEV
  • /FVC greater than 60% by pulmonary function test OR
  • Pulse oximetry greater than 94% AND
  • No evidence of dyspnea at rest AND
  • No exercise intolerance


  • Adequate venous access
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception


  • Not specified


  • No prior chemotherapy

Endocrine therapy:

  • At least 1 month since prior corticosteroids except prednisone for respiratory distress


  • No prior radiotherapy


  • See Disease Characteristics

Location and Contact Information

      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35233,  United States; Recruiting
Robert P. Castleberry, MD  205-939-9285 

      University of South Alabama Cancer Research Institute, Mobile,  Alabama,  36604,  United States; Recruiting
Felicia L. Wilson, MD  251-405-5115 

      Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson,  Arizona,  85724,  United States; Recruiting
Rochelle Bagatell, MD  520-626-4851 

      Phoenix Children's Hospital, Phoenix,  Arizona,  85016,  United States; Recruiting
Dale Anne Singer, MD  602-546-0920 

      Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock,  Arkansas,  72205,  United States; Recruiting
David L. Becton, MD  501-320-5650 

      Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange,  California,  92868,  United States; Recruiting
Stanley Calderwood, MD  714-456-6615 

      Children's Hospital and Health Center, San Diego, San Diego,  California,  92123-4282,  United States; Recruiting
Richard Kadota, MD  858-966-5811 

      Children's Hospital and Research Center at Oakland, Oakland,  California,  94609-1809,  United States; Recruiting
James H. Feusner, MD  510-428-3000 

      Children's Hospital Central California, Madera,  California,  93638-8762,  United States; Recruiting
Vonda Lee Crouse, MD  559-353-5480 

      Children's Hospital Los Angeles, Los Angeles,  California,  90027-0700,  United States; Recruiting
Paul S. Gaynon, MD  323-669-2163 

      Children's Hospital of Orange County, Orange,  California,  92868,  United States; Recruiting
Wei-Ping Violet Shen, MD  714-516-4348 

      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States; Recruiting
Clinical Trials Office - New Patient Services  800-826-4673 

      General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base,  California,  94535,  United States; Recruiting
Peter J. Chenaille, MD  707-423-7176 

      Jonathan Jaques Children's Cancer Center at Miller Children's Hospital, Long Beach,  California,  90801-1428,  United States; Recruiting
William Mark Roberts, MD  562-933-8600 

      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1781,  United States; Recruiting
Stephen A. Feig, MD  310-825-5268 

      Kaiser Permanente Medical Center - Sacramento, Sacramento,  California,  95825,  United States; Recruiting
Vincent A. Kiley, MD  916-973-7331 

      Kaiser Permanente Medical Center - Santa Clara, Santa Clara,  California,  95051-5386,  United States; Recruiting
Carolyn Lucille Russo, MD  408-236-5028 

      Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego,  California,  92120,  United States; Recruiting
Wellington Loh, MD  619-516-6144 

      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States; Recruiting
Antranik Bedros, MD  909-558-8626 

      Lucile Packard Children's Hospital at Stanford University Medical Center, Palo Alto,  California,  94304,  United States; Recruiting
Neyssa M. Marina, MD  650-723-5535 

      Rebecca and John Moores UCSD Cancer Center, La Jolla,  California,  92093-0658,  United States; Recruiting
Richard Kadota, MD  858-657-7020 

      Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles,  California,  90048,  United States; Recruiting
Moshe Arditi, MD  310-423-4471 

      Santa Barbara Cottage Hospital, Santa Barbara,  California,  93102,  United States; Recruiting
Felicity Hodder, MD  805-682-7111 

      Southern California Permanente Medical Group, Downey,  California,  90242,  United States; Recruiting
Willye B. Powell, MD  562-803-2472 

      Sutter Cancer Center, Sacramento,  California,  95816,  United States; Recruiting
Yisheng Lee, MD, PhD, MBA  916-733-1757 

      UCSF Comprehensive Cancer Center, San Francisco,  California,  94143,  United States; Recruiting
Katherine K. Matthay, MD  415-476-3831 

      University of California Davis Cancer Center, Sacramento,  California,  95817,  United States; Recruiting
Theodore Zwerdling, MD  916-734-2781 

      Children's Hospital Cancer Center, Denver,  Colorado,  80218,  United States; Recruiting
Lorrie F. Odom, MD  303-861-6740 

      Presbyterian - St. Luke's Medical Center, Denver,  Colorado,  80218,  United States; Recruiting
Stephen R. Palmer, MD  719-471-2462 

      Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington,  Connecticut,  06360-7106,  United States; Recruiting
Arnold J. Altman, MD  860-545-9630 

      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8064,  United States; Recruiting
Jack van Hoff, MD  203-785-4640 

      Alfred I. duPont Hospital for Children, Wilmington,  Delaware,  19899,  United States; Recruiting
Rita S. Meek, MD  302-651-5502 

District of Columbia
      Children's National Medical Center, Washington,  District of Columbia,  20010-2970,  United States; Recruiting
Nita Louise Seibel, MD  202-884-2144 

      Lombardi Cancer Center at Georgetown University Medical Center, Washington,  District of Columbia,  20007,  United States; Recruiting
Aziza Shad, MD  202-444-2224 

      All Children's Hospital, St. Petersburg,  Florida,  33701,  United States; Recruiting
Jerry L. Barbosa, MD  727-892-4231 

      Baptist-South Miami Regional Cancer Program, Miami,  Florida,  33176-2197,  United States; Recruiting
Doured Daghistani, MD  786-596-1960 

      Broward General Medical Center, Fort Lauderdale,  Florida,  33316,  United States; Recruiting
Rudolph R. Roskos, MD  954-355-4527 

      Children's Hospital of Southwest Florida, Fort Myers,  Florida,  33908,  United States; Recruiting
Emad K. Salman, MD  239-432-3333 

      Florida Hospital Cancer Institute, Orlando,  Florida,  32804,  United States; Recruiting
Jane Crofton, RN, BSN, OCN  407-303-2090 

      Jackson Memorial Hospital, Miami,  Florida,  33136,  United States; Recruiting
Stuart R. Toledano, MD  305-585-5635 

      Joe DiMaggio Children's Hospital at Memorial, Hollywood,  Florida,  33021,  United States; Recruiting
Iftikhar Hanif, MD  954-986-2234 

      Miami Children's Hospital, Miami,  Florida,  33155,  United States; Recruiting
Enrique A. Escalon, MD  305-666-6511 

      Nemours Children's Clinic, Jacksonville,  Florida,  32207,  United States; Recruiting
Eric Sandler, MD  904-390-3793 

      Nemours Children's Clinic-Orlando, Orlando,  Florida,  32806,  United States; Recruiting
Vincent F. Giusti, MD  407-650-7230 

      Sacred Heart Children's Hospital, Pensacola,  Florida,  32504,  United States; Recruiting
John F. Kelleher, MD  850-505-4798 

      St. Joseph's Children's Hospital, Tampa,  Florida,  33677-4227,  United States; Recruiting
Cameron K. Tebbi, MD  813-870-4252 

      St. Mary's Hospital, West Palm Beach,  Florida,  33407,  United States; Recruiting
Narayana Gowda, MD  561-840-6125 

      AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta,  Georgia,  30342,  United States; Recruiting
Howard M. Katzenstein, MD  404-785-0853 

      Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah,  Georgia,  31405,  United States; Recruiting
Tribhawan S. Vats, MD  912-350-8194 

      MBCCOP-Medical College of Georgia Cancer Center, Augusta,  Georgia,  30912-4000,  United States; Recruiting
Roger A. Vega, MD  706-721-3626 

      Medical Center of Central Georgia, Macon,  Georgia,  31201,  United States; Recruiting
Hassan Dannawi, MD  478-633-1104 

      Cancer Research Center of Hawaii, Honolulu,  Hawaii,  96813,  United States; Recruiting
Robert Warren Wilkinson, MD  808-586-2979 

      Tripler Army Medical Center, Honolulu,  Hawaii,  96859-5000,  United States; Recruiting
Braden Alan Shoupe, MD  808-433-6057 

      Mountain States Tumor Institute - Boise, Boise,  Idaho,  83712,  United States; Recruiting
J. Martin Johnston, MD  208-381-2782 

      Advocate Hope Children's Hospital, Oak Lawn,  Illinois,  60453,  United States; Recruiting
Sharad N. Salvi, MD  708-346-4094 

      Children's Memorial Hospital - Chicago, Chicago,  Illinois,  60614,  United States; Recruiting
Susan Lerner Cohn, MD  773-880-4562 

      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068-1174,  United States; Recruiting
Jong-Hyo Kwon, MD  847-723-5962 

      Rush University Medical Center, Chicago,  Illinois,  60612,  United States; Recruiting
Allen D. Korenblit, MD  312-942-5983 

      Saint Jude Midwest Affiliate, Peoria,  Illinois,  61637,  United States; Recruiting
John A. McCallister, MD  309-624-4945 

      Southern Illinois University School of Medicine, Springfield,  Illinois,  62794-9658,  United States; Recruiting
Gregory Brandt, MD  217-545-5817 

      University of Chicago Cancer Research Center, Chicago,  Illinois,  60601,  United States; Recruiting
James B. Nachman, MD  773-702-6808 

      University of Illinois Medical Center, Chicago,  Illinois,  60612,  United States; Recruiting
Mary Lou Schmidt, MD  312-996-6143 

      Riley Children Cancer Center at Riley Hospital for Children, Indianapolis,  Indiana,  46202-5225,  United States; Recruiting
Robert Fallon, MD, PhD  317-274-8784 

      St. Vincent Hospitals and Health Care Centers, Indianapolis,  Indiana,  46260,  United States; Recruiting
Randy Alan Hock, MD, PhD, MMM  317-338-4673 

      Blank Children's Hospital, Des Moines,  Iowa,  50309,  United States; Recruiting
Stephen C. Elliott, DO, PhD, FAAP  515-241-6000 

      Holden Comprehensive Cancer Center at University of Iowa, Iowa City,  Iowa,  52242-1009,  United States; Recruiting
Raymond Tannous, MD  319-356-1905 

      Wesley Medical Center, Wichita,  Kansas,  67214,  United States; Recruiting
David Rosen, MD  316-962-2025 

      Kosair Children's Hospital, Louisville,  Kentucky,  40202-3830,  United States; Recruiting
Salvatore J. Bertolone, MD  502-852-8450 

      Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington,  Kentucky,  40536-0284,  United States; Recruiting
Martha F. Greenwood, MD  859-323-6771 

      Children's Hospital of New Orleans, New Orleans,  Louisiana,  70118,  United States; Recruiting
Lolie Chua Yu, MD  504-896-9740 

      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States; Recruiting
Jill Gilbert, MD  504-568-5613 

      Ochsner Cancer Institute at Ochsner Clinic Foundation, New Orleans,  Louisiana,  70121,  United States; Recruiting
Marquis Zimri Hodes, MD, PhD  504-842-5230 

      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112,  United States; Recruiting
Marshall A. Schorin, MD  504-988-5412 

      CancerCare of Maine at Eastern Maine Medial Center, Bangor,  Maine,  04401,  United States; Recruiting
Judith B. Allen, MD  207-973-7520 

      Maine Children's Cancer Program, Scarborough,  Maine,  04074-9308,  United States; Recruiting
Craig A. Hurwitz, MD  207-885-7565 

      Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore,  Maryland,  21215,  United States; Recruiting
Joseph Michael Wiley, MD  410-601-5864 

      Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore,  Maryland,  21201-1595,  United States; Recruiting
Neil Jeffrey Grossman, MD  410-328-2808 

      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States; Recruiting
Cindy Schwartz, MD  410-955-7385 

      Walter Reed Army Medical Center, Silver Spring,  Maryland,  20910,  United States; Recruiting
Kip R. Hartman, MD  301-319-9116 

      Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield,  Massachusetts,  01107,  United States; Recruiting
David A. Steele, MD  413-794-9338 

      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02115,  United States; Recruiting
Holcombe Edwin Grier, MD  617-632-3971 

      Floating Hospital for Children, Boston,  Massachusetts,  02111,  United States; Recruiting
Cynthia S. Kretschmar, MD  617-636-5535 

      UMASS Memorial Cancer Center - University Campus, Worcester,  Massachusetts,  01655,  United States; Recruiting
Ghazala Naheed Usmani, MD  508-856-4225 

      Breslin Cancer Center at Ingham Regional Medical Center, Lansing,  Michigan,  48910,  United States; Recruiting
Renuka Gera, MD  517-334-2337 

      Bronson Methodist Hospital, Kalamazoo,  Michigan,  49007-5364,  United States; Recruiting
Leonard August Mattano, MD, PhD  616-341-6350 

      Children's Hospital of Michigan, Detroit,  Michigan,  48201,  United States; Recruiting
Yaddanapudi Ravindranath, MBBS  313-745-5649 

      DeVos Children's Hospital, Grand Rapids,  Michigan,  49503,  United States; Recruiting
David Robert Freyer, DO  616-391-2086 

      Hurley Medical Center, Flint,  Michigan,  48503,  United States; Recruiting
Susumu Inoue, MD  810-762-7303 

      Josephine Ford Cancer Center at Henry Ford Health System, Detroit,  Michigan,  48202,  United States; Recruiting
Hassan M. Yaish, MD  313-916-3138 

      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0914,  United States; Recruiting
Raymond J. Hutchinson, MD  734-936-8785 

      Van Elslander Cancer Center at St. John Hospital and Medical Center, Detroit,  Michigan,  48236,  United States; Recruiting
Hadi Sawaf, MD  313-647-3200 

      William Beaumont Hospital - Royal Oak, Royal Oak,  Michigan,  48073-6769,  United States; Recruiting
Charles A. Main, MD  248-551-0360 

      Children's Hospitals and Clinics - Minneapolis/St. Paul, Minneapolis,  Minnesota,  55404,  United States; Recruiting
Maura C. O'Leary, MD  612-813-5940 

      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905,  United States; Recruiting
Carola A.S. Arndt, MD  507-284-2511 

      St. Mary's - Duluth Clinic Cancer Center, Duluth,  Minnesota,  55805,  United States; Recruiting
Jacquelyn Dawn Wiermaa, MD  218-786-3625 

      University of Mississippi Medical Center, Jackson,  Mississippi,  39216-4505,  United States; Recruiting
Dale Jeanette Pullen, MD  601-984-5220 

      Cardinal Glennon Children's Hospital, Saint Louis,  Missouri,  63104,  United States; Recruiting
William Shay Ferguson, MD  314-577-5638 

      Children's Mercy Hospital, Kansas City,  Missouri,  64108,  United States; Recruiting
Maxine L. Hetherington, MD  816-234-3265 

      St. Louis Children's Hospital, Saint Louis,  Missouri,  63110,  United States; Recruiting
Robert James Hayashi, MD  314-454-4118 

      Children's Hospital of Omaha, Omaha,  Nebraska,  68114,  United States; Recruiting
Minnie Abromowitch, MD  402-955-3949 

      UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha,  Nebraska,  68198-2168,  United States; Recruiting
Peter F. Coccia, MD  402-559-7257 

      Sunrise Hospital and Medical Center, Las Vegas,  Nevada,  89109,  United States; Recruiting
Jonathan Bernstein, MD  702-732-0971 

New Hampshire
      Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon,  New Hampshire,  03756,  United States; Recruiting
Eric Christian Larsen, MD  603-650-5541 

New Jersey
      Cancer Center at Hackensack University Medical Center, Hackensack,  New Jersey,  07601,  United States; Recruiting
Michael B. Harris, MD  201-996-5437 

      Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick,  New Jersey,  08903,  United States; Recruiting
Richard A. Drachtman, MD  732-235-5437 

      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112-2094,  United States; Recruiting
Peri Kamalakar, MD  973-926-7161 

      St. Joseph's Hospital and Medical Center, Paterson,  New Jersey,  07503,  United States; Recruiting
Mary Ann Bonilla, MD  973-754-3230 

      Valerie Fund Children's Center at Atlantic Health, Summit,  New Jersey,  07901,  United States; Recruiting
Hazem Helmy Mahmoud, MD  973-971-6731 

New Mexico
      University of New Mexico Cancer Research and Treatment Center, Albuquerque,  New Mexico,  87131,  United States; Recruiting
Jami Frost, MD  505-272-4461 

New York
      Albert Einstein Cancer Center at Albert Einstein College of Medicine, Bronx,  New York,  10461,  United States; Recruiting
Eva Radel, MD  718-920-7844 

      Brookdale University Hospital and Medical Center, Brooklyn,  New York,  11212,  United States; Recruiting
Kusum Viswanathan, MD  718-240-5904 

      Brooklyn Hospital Center, Brooklyn,  New York,  11201-5493,  United States; Recruiting
Swayamprabha Sadanandan, MD  718-250-6074 

      Cancer Center of Albany Medical Center, Albany,  New York,  12208,  United States; Recruiting
Jennifer M. Pearce, MD  518-262-5513 

      Comprehensive Cancer Center at Maimonides Medical Center, Brooklyn,  New York,  11219,  United States; Recruiting
Ludovico Guarini, MD  718-283-8173 

      Herbert Irving Comprehensive Cancer Center at Columbia University, New York,  New York,  10032,  United States; Recruiting
Linda Granowetter, MD  212-305-8652 

      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States; Recruiting
Barbara Lawrence Asselin, MD  716-275-2981 

      Long Island Cancer Center at Stony Brook University Hospital, Stony Brook,  New York,  11794,  United States; Recruiting
Robert Ingalls Parker, DSc  631-444-4000 

      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States; Recruiting
Peter G. Steinherz, MD  212-639-7951 

      Mount Sinai School of Medicine, New York,  New York,  10029,  United States; Recruiting
Elizabeth Raetz, MD  212-241-7022 

      New York Medical College, Valhalla,  New York,  10595,  United States; Recruiting
M. Fevzi Ozkaynak, MD  914-493-7997 

      New York Weill Cornell Cancer Center at Cornell University, New York,  New York,  10021,  United States; Recruiting
Patricia J.V. Giardina, MD  212-746-3400 

      Schneider Children's Hospital, New Hyde Park,  New York,  11042,  United States; Recruiting
Arlene Sara Redner, MD  718-470-3460 

      SUNY Downstate Medical Center, Brooklyn,  New York,  11203,  United States; Recruiting
Sreedhar P. Rao, MD  718-270-1693 

      SUNY Upstate Medical University Hospital, Syracuse,  New York,  13210,  United States; Recruiting
Ronald L. Dubowy, MD  315-464-5294 

North Carolina
      Blumenthal Cancer Center at Carolinas Medical Center, Charlotte,  North Carolina,  28232-2861,  United States; Recruiting
Daniel P. McMahon, MD  704-355-1130 

      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1081,  United States; Recruiting
Thomas Williams McLean, MD  336-716-4324 

      Duke Comprehensive Cancer Center, Durham,  North Carolina,  27710,  United States; Recruiting
Philip Paul Breitfeld, MD  919-684-3377 

      Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital, Greenville,  North Carolina,  27858-4354,  United States; Recruiting
Charles W. Daeschner, MD  252-744-4676 

      Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill,  North Carolina,  27599,  United States; Recruiting
Stuart Gold, MD  919-966-0985 

      Mission Hospitals, Asheville,  North Carolina,  28801,  United States; Recruiting
Orren Beaty, DO, PhD  823-213-5770 

      Presbyterian Cancer Center at Presbyterian Hospital, Charlotte,  North Carolina,  28233,  United States; Recruiting
Mark Mogul, MD  704-384-1900 

North Dakota
      Dakota Cancer Institute at Innovis Health - Dakota Clinic, Fargo,  North Dakota,  58103-4940,  United States; Recruiting
Janet K. Tillisch, MD  701-364-4964 

      Children's Hospital Medical Center of Akron, Akron,  Ohio,  44308-1062,  United States; Recruiting
Steven J. Kuerbitz, MD  330-543-8730 

      Children's Medical Center - Dayton, Dayton,  Ohio,  45404,  United States; Recruiting
Emmett H. Broxson, MD, FAAP  937-641-3111 

      Cincinnati Children's Hospital Medical Center, Cincinnati,  Ohio,  45229-3039,  United States; Recruiting
John Peter Perentesis, MD  513-636-6090 

      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195,  United States; Recruiting
Karen A. Bringelsen, MD  216-444-7923 

      Columbus Children's Hospital, Columbus,  Ohio,  43205-2696,  United States; Recruiting
Amanda Termuhlen, MD  614-722-3552 

      Forum Health-Tod Childrens Hospital, Youngstown,  Ohio,  44501,  United States; Recruiting
Ayman Saleh, MD, FAAP  330-884-3955 

      Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland,  Ohio,  44106-5065,  United States; Recruiting
Susan Wiersma, MD  216-844-3345 

      St. Vincent Mercy Medical Center, Toledo,  Ohio,  43608,  United States; Recruiting
Rama Jasty, MD  419-251-8215 

      Toledo Children's Hospital, Toledo,  Ohio,  43601,  United States; Recruiting
Richard M. Shore, MD  419-471-5437 

      Children's Hospital at Oklahoma University Medical Center, Oklahoma City,  Oklahoma,  73104,  United States; Recruiting
William H. Meyer, MD  405-271-5311 

      Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa,  Oklahoma,  74136,  United States; Recruiting
Martina Christine Hum, MD  918-494-2525 

      CCOP - Columbia River Oncology Program, Portland,  Oregon,  97225,  United States; Recruiting
Keith S. Lanier, MD  503-216-6260 

      Doernbecher Children's Hospital at Oregon Health & Science University, Portland,  Oregon,  97239-3098,  United States; Recruiting
H. Stacy Nicholson, MD, MPH  503-494-1543 

      Legacy Emanuel Hospital and Health Center & Children's Hospital, Portland,  Oregon,  97227,  United States; Recruiting
Janice Faye Olson, MD  503-413-2200 

      Children's Hospital at Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033,  United States; Recruiting
John E. Neely, MD  717-531-6012 

      Children's Hospital of Philadelphia, Philadelphia,  Pennsylvania,  19104,  United States; Recruiting
Richard Berry Womer, MD  215-590-2229 

      Children's Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15213,  United States; Recruiting
Arthur Kim Ritchey, MD  412-692-5055 

      Geisinger Medical Center, Danville,  Pennsylvania,  17822-1320,  United States; Recruiting
Jeffrey Taylor, MD  570-271-6848 

      St. Christopher's Hospital for Children, Philadelphia,  Pennsylvania,  19134-1095,  United States; Recruiting
Gregory E. Halligan, MD  215-427-5000 

Rhode Island
      Rhode Island Hospital, Providence,  Rhode Island,  02903,  United States; Recruiting
Sam W. Lew, MD  401-444-5171 

South Carolina
      Children's Hospital of Greenville Hospital System, Greenville,  South Carolina,  29605,  United States; Recruiting
Cary Ernest Stroud, MD  864-455-8898 

      Hollings Cancer Center at Medical University of South Carolina, Charleston,  South Carolina,  29425-0721,  United States; Recruiting
Julio C. Barredo, MD  843-792-2957 

      Palmetto Health South Carolina Cancer Center, Columbia,  South Carolina,  29203,  United States; Recruiting
Ronnie W. Neuberg, MD  803-434-3533 

South Dakota
      Avera Cancer Institute, Sioux Falls,  South Dakota,  57105-1080,  United States; Recruiting
Marwan D. Hanna, MD  605-322-7595 

      Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls,  South Dakota,  57117-5039,  United States; Recruiting
Jakica Tancabelic, MD  605-333-7171 

      East Tennessee Children's Hospital, Knoxville,  Tennessee,  37901,  United States; Recruiting
Ray C. Pais, MD  865-541-8266 

      East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City,  Tennessee,  37614-0622,  United States; Recruiting
David K. Kalwinsky, MD  423-433-6200    sjcrhta@msha,cin 

      St. Jude Children's Research Hospital, Memphis,  Tennessee,  38105-2794,  United States; Recruiting
Wayne Lee Furman, MD  901-495-3300 

      Vanderbilt Children's Hospital, Nashville,  Tennessee,  37232-6310,  United States; Recruiting
James A. Whitlock, MD  615-936-1762 

      Baylor College of Medicine, Houston,  Texas,  77030,  United States; Recruiting
C. Philip Steuber, MD  713-798-6970 

      CCOP - Scott and White Hospital, Temple,  Texas,  76508,  United States; Recruiting
Lucas Wong, MD  254-724-1053 

      Center for Cancer Prevention and Care at Scott and White Clinic, Temple,  Texas,  76508,  United States; Recruiting
Dick Suh, MD, PhD  254-724-9852 

      Children's Hospital of Austin, Austin,  Texas,  78701,  United States; Recruiting
Sharon K. Lockhart, MD  512-324-8480 

      Cook Children's Medical Center - Fort Worth, Fort Worth,  Texas,  76104,  United States; Recruiting
Timothy C. Griffin, MD  682-885-4020 

      Covenant Children's Hospital, Lubbock,  Texas,  79410,  United States; Recruiting
John Iacuone, MD  806-725-4840 

      MBCCOP - South Texas Pediatrics, San Antonio,  Texas,  78229-3900,  United States; Recruiting
Anne-Marie Langevin, MD  210-704-3405 

      MD Anderson Cancer Center at University of Texas, Houston,  Texas,  77030-4009,  United States; Recruiting
Joann Ater, MD  713-792-6665 

      Medical City Dallas Hospital, Dallas,  Texas,  75230,  United States; Recruiting
Carl Lenarsky, MD  972-566-6647 

      Methodist Cancer Center at Methodist Specialty and Transplant Hospital, San Antonio,  Texas,  78229-3902,  United States; Recruiting
Jaime Estrada, MD  210-575-8130 

      San Antonio Military Pediatric Cancer and Blood Disorders Center, Lackland Air Force Base,  Texas,  78236,  United States; Recruiting
Aaron Pitney, MD  210-292-5684 

      Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas,  Texas,  75390-9063,  United States; Recruiting
Naomi J. Winick, MD  214-648-3074 

      Texas Tech University Health Sciences Center School of Medicine, Amarillo,  Texas,  79106,  United States; Recruiting
Curtis Wade Turner, MD  806-354-5434 

      University of Texas Health Science Center at San Antonio, San Antonio,  Texas,  78207,  United States; Recruiting
Paul Jan Thomas, MD  210-704-3405 

      University of Texas Medical Branch, Galveston,  Texas,  77555-0209,  United States; Recruiting
Frederick Szujuei Huang, MD  409-772-2341 

      Huntsman Cancer Institute at University of Utah, Salt Lake City,  Utah,  84112,  United States; Recruiting
Carol S. Bruggers, MD  801-585-0303 

      Vermont Cancer Center at University of Vermont, Burlington,  Vermont,  05401-3498,  United States; Recruiting
Alan C. Homans, MD  802-847-2850 

      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States; Recruiting
Kimberly Dunsmore, MD  434-924-9333 

      Carilion Medical Center for Children at Roanoke Community Hospital, Roanoke,  Virginia,  24029,  United States; Recruiting
Joan Mistretta Fisher, MD, PhD  540-985-8055 

      Children's Hospital of the King's Daughters, Norfolk,  Virginia,  23507,  United States; Recruiting
Rebecca L. Byrd, MD  757-668-7243 

      INOVA Fairfax Hospital, Falls Church,  Virginia,  22042-3300,  United States; Recruiting
Jay N. Greenberg, MD  703-698-1110 

      Massey Cancer Center at Virginia Commonwealth University, Richmond,  Virginia,  23298-0121,  United States; Recruiting
Nancy L. Dunn, MD  804-828-9605 

      Naval Medical Center, Portsmouth, Portsmouth,  Virginia,  23708-5100,  United States; Recruiting
Paulette Charese Bryant, MD  804-398-5767 

      Children's Hospital and Regional Medical Center - Seattle, Seattle,  Washington,  98105,  United States; Recruiting
Douglas Hawkins, MD  206-987-3096 

      Deaconess Medical Center, Spokane,  Washington,  99210-0248,  United States; Recruiting
Steven K. Bergstrom, MD  509-473-7012 

      Fred Hutchinson Cancer Research Center, Seattle,  Washington,  98109-1024,  United States; Recruiting
Jean E. Sanders, MD

More Information

Clinical trial summary from the National Cancer Institute's PDQ® database

Study ID Numbers:  CDR0000068943; COG-AHOD0031; NCT00025259
Record last reviewed:  February 2005
Last Updated:  April 4, 2005
Record first received:  October 11, 2001 Identifier:  NCT00025259
Health Authority: United States: Federal Government processed this record on 2005-04-08

Cache Date: April 9, 2005

Common Treatments

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