Tissue Studies of Human Eye Diseases - Article
Clinical Trial: Tissue Studies of Human Eye Diseases
This study is currently recruiting patients.
The purpose of this study is to better understand the processes involved in the development of various eye conditions, such as uveitis, disorders of the conjunctiva, cornea, vitreous and retina, metabolic or genetic eye diseases or eye tumors, in order to develop better methods of diagnosis and treatment.
Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study. Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study. The tissues will be examined under microscope and studied using sophisticated chemical and biological tests. Immune cells from blood samples may also be examined. These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies.
|Conjunctival Disease |
MedlinePlus related topics: Eye Diseases; Retinal Disorders
Study Type: Observational
Study Design: Natural History
Official Title: Immunopathology of Ocular Diseases in Humans
Expected Total Enrollment: 3000
Study start: March 5, 1992
The purpose of this project is to diagnose and evaluate ocular tissues with various diseases such as uveitis, conjunctival, corneal, vitreoretinal disorders, ocular metabolic or genetic diseases and tumors. These will be studied using light microscopy, electron microscopy, confocal microscopy, immunohistochemical techniques, in situ hybridization and the molecular pathological techniques including polymerase chain reaction. Lymphocyte subsets in the peripheral blood as well as other involved biopsied tissues and ocular tissue will be compared and categorized by disease. Cytokines in the blood and ocular fluids will be also analyzed. Elucidating the relationship between the infiltrating cells, ocular resident cells, and their products in various diseases will increase our understanding of human ocular disorders.
Genders Eligible for Study: Both
All specimens either male or female of any age with ocular disease that are collected at the NEI or its collaborating institutes, will be included in the study. Specimens would consist of material obtained from surgical specimens, biopsy specimens, and from post mortem materials. These would include but would not be limited to cases involving uveal, conjunctival, corneal, vitreo-retinal, orbital disorders, tumor, and metabolic abnormalities.
Location and Contact Information
National Eye Institute (NEI), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting
Detailed Web Page
Whitcup SM, Stark-Vancs V, Wittes RE, Solomon D, Podgor MJ, Nussenblatt RB, Chan CC. Association of interleukin 10 in the vitreous and cerebrospinal fluid and primary central nervous system lymphoma. Arch Ophthalmol. 1997 Sep;115(9):1157-60.
Chan CC, Matteson DM, Li Q, Whitcup SM, Nussenblatt RB. Apoptosis in patients with posterior uveitis. Arch Ophthalmol. 1997 Dec;115(12):1559-67.
Chan CC, Li Q. Immunopathology of uveitis. Br J Ophthalmol. 1998 Jan;82(1):91-6. Review. No abstract available.
Record last reviewed: April 16, 2004
Last Updated: March 16, 2005
Record first received: November 3, 1999
ClinicalTrials.gov Identifier: NCT00001310
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Cache Date: April 9, 2005