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Factor IX (or Christmas factor or Christmas-Eve factor) is one of the serine proteases (EC 3.4.21.22) of the coagulation system; it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B.

Group of hereditary disorders in which affected individuals fail to make enough of certain proteins needed to form blood clots.


Factor IX as related to Hemophilia


  • Hemophilia B | National Hemophilia Foundation
    Factor IX products are used to manage acute bleeding or to prevent excessive bleeding as a treatment for patients with hemophilia B. Nufactor carries the following F.D.A.-approved Factor IX products: * Denotes that Nufactor does not currently carry this product.

  • Hemophilia B: MedlinePlus Medical Encyclopedia
    If the factor IX gene is missing on a boy's X chromosome, he will have Hemophilia B. For this reason, most people with hemophilia B are male. If a woman has a defective factor IX gene, she is considered a carrier.

  • 086298: Factor IX Activity | LabCorp
    A subtype of hemophilia B, hemophilia B Leiden, is characterized by altered developmental expression of factor IX such that plasma factor IX levels may be <1% of normal during childhood, but after puberty may gradually rise to a maximum of 70% of normal. 12 Hemophilia B can also occur as the result of spontaneous mutations of the factor IX gene ...

  • Diagnosis of Hemophilia | CDC
    This is because factor IX (9) levels take more time to develop and are not at a normal level until a baby is at least 6 months of age. Therefore, a mildly low level of factor IX (9) at birth does not necessarily mean that the baby has hemophilia B. A repeat test when the baby is older might be needed in some cases.

  • Hemophilia - Genetics Home Reference - NIH
    The major types of this condition are hemophilia A (also known as classic hemophilia or factor VIII deficiency) and hemophilia B (also known as Christmas disease or factor IX deficiency). Although the two types have very similar signs and symptoms, they are …