Herpes Zoster; Post-herpetic Neuralgia 


Herpes zoster, colloquially known as shingles, is the reactivation of varicella zoster virus, leading to a crop of painful blisters over the area of a dermatome. It occurs very rarely in children and adults, but its incidence is high in the elderly (over 60), as well as in any age group of immunocompromised patients. It strikes 500,000 people per year in the United States. Treatment is generally with acyclovir. Many develop a painful condition termed postherpetic neuralgia.

Imipramine (tradenames: Janimine®, Tofranil®) is an antidepressant medication belonging to a class called tricyclic antidepressants of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis.

Shingles as related to Imipramine