RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as thalidomide may stop the growth of brain metastases by stopping blood flow to the tumor. It is not yet known whether radiation therapy is more effective with or without thalidomide in treating brain metastases.

PURPOSE: Randomizedphase III trial to compare the effectiveness of radiation therapy with or without thalidomide in treating patients who have brain metastases.

Condition	Treatment or Intervention	Phase
brain metastases	Drug: thalidomide  Procedure: anti-cytokine therapy  Procedure: antiangiogenesis therapy  Procedure: biological response modifier therapy  Procedure: growth factor antagonist therapy  Procedure: radiation therapy	Phase III

Further Study Details: 

OBJECTIVES:

• Compare the overall survival of patients with multiple brain metastases treated with radiotherapy with or without thalidomide.
• Compare the time to tumor progression in patients treated with these regimens.
• Compare the time to neuro-cognitive progression in patients treated with these regimens.
• Compare the cause of death distribution in patients treated with these regimens.
• Compare the frequency of toxic effects of these regimens in these patients.
• Evaluate and compare the quality of life of patients treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to recursive partitioning analysis class (I vs II) and planned chemotherapy after whole brain irradiation (yes vs no). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients undergo radiotherapy once daily 5 days a week for 3 weeks.
• Arm II: Patients undergo radiotherapy as in arm I. Beginning on the first day of radiotherapy, patients receive oral thalidomide once daily. Treatment with thalidomide continues for 2 years in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, at completion of radiotherapy, and then every 2 months for 1 year.

Patients are followed every 2 months for 1 year, every 4 months for 1 year, every 6 months for 2 years, and then annually thereafter.

PROJECTED ACCRUAL: A total of 332 patients (166 per treatment arm) will be accrued for this study within 14.5 months.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed extracranial primary malignancy
• Multiple brain metastases
• At least 1 measurable brain metastasis by MRI
• More than 4.0 cm OR
• Located in midbrain or brainstem (radiosurgery ineligible)

PATIENT CHARACTERISTICS: Age:

• Over 18

Performance status:

• Zubrod 0-1

Life expectancy:

• At least 8 weeks

Hematopoietic:

• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3
• Hemoglobin at least 11 g/dL*
• Hematocrit at least 35%* NOTE: * Transfusion and/or epoetin alfa allowed

Hepatic:

• Bilirubin no greater than 1.5 mg/dL
• ALT no greater than 2 times normal

Renal:

• Creatinine no greater than 1.5 mg/dL
• BUN no greater than 25 mg/dL

Cardiovascular:

• No history of deep venous thrombosis

Other:

• No sensory neuropathy grade 2 or greater
• No known AIDS
• No other major medical illness or psychiatric impairments that would preclude study therapy
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier method of contraception during and for at least 4 weeks after study

PRIOR CONCURRENT THERAPY: Biologic therapy:

• No prior thalidomide

Chemotherapy:

• More than 2 weeks since prior chemotherapy
• Concurrent chemotherapy allowed if more than 6 weeks past study entry (allowed during first 6 weeks of study if disease progression occurs)

Endocrine therapy:

• Not specified

Radiotherapy:

• See Disease Characteristics
• No prior radiotherapy to the head or neck
• No prior radiosurgery

Surgery:

• Prior resection of brain metastases allowed

Other:

• No concurrent anticoagulant therapy

Alabama
      Comprehensive Cancer Institute, Huntsville,  Alabama,  35801,  United States
      DCH Cancer Treatment Center, Tuscaloosa,  Alabama,  35401,  United States
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36607,  United States
      Montgomery Cancer Center, Montgomery,  Alabama,  36106-3657,  United States
      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35294-3300,  United States
Arizona
      Foundation for Cancer Research and Education, Phoenix,  Arizona,  85013,  United States
California
      California Cancer Center, Fresno,  California,  93720,  United States
      CCOP - Bay Area Tumor Institute, Oakland,  California,  94609-3305,  United States
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States
      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States
      David Grant Medical Center, Travis Air Force Base,  California,  94535,  United States
      Huntington Cancer Center at Huntington Hospital, Pasadena,  California,  91105,  United States
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1714,  United States
      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States
      Mount Diablo Medical Center, Concord,  California,  94524-4110,  United States
      Naval Medical Center - San Diego, San Diego,  California,  92134-3202,  United States
      O'Connor Hospital, San Jose,  California,  95128,  United States
      Providence Saint Joseph Medical Center - Burbank, Burbank,  California,  91505,  United States
      Radiation Medical Group, Incorporated, San Diego,  California,  92101,  United States
      Radiation Oncology Centers - Sacramento, Sacramento,  California,  95816,  United States
      Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona,  California,  91767,  United States
      Saint Agnes Cancer Center, Fresno,  California,  93720,  United States
      Sutter Health Western Division Cancer Research Group, Greenbrae,  California,  94904,  United States
      Torrance Memorial Medical Center, Torrance,  California,  90505,  United States
      UCSF Comprehensive Cancer Center, San Francisco,  California,  94115,  United States
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90033-0804,  United States
      Veterans Affairs Medical Center - Long Beach, Long Beach,  California,  90822,  United States
Colorado
      CCOP - Colorado Cancer Research Program, Incorporated, Denver,  Colorado,  80224,  United States
      Memorial Hospital Cancer Center, Colorado Springs,  Colorado,  80909,  United States
      St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction,  Colorado,  81502-1628,  United States
      University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver,  Colorado,  80010,  United States
Connecticut
      Hospital of St. Raphael, New Haven,  Connecticut,  06511,  United States
      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8040,  United States
Delaware
      CCOP - Christiana Care Health Services, Newark,  Delaware,  19713,  United States
District of Columbia
      Sibley Memorial Hospital, Washington,  District of Columbia,  20016,  United States
Florida
      21st Century Oncology - Fort Myers, Fort Myers,  Florida,  33901-8082,  United States
      Baptist Hospital of Miami, Miami,  Florida,  33176-2197,  United States
      Bay Medical Center, Panama City,  Florida,  32401,  United States
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States
      Florida Radiation Oncology Group, Jacksonville,  Florida,  32207,  United States
      Gulf Coast Cancer Treatment Center, Panama City,  Florida,  32405-4587,  United States
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States
      Holmes Regional Medical Center, Melbourne,  Florida,  32901-3276,  United States
      MD Anderson Cancer Center Orlando, Orlando,  Florida,  32806-2134,  United States
      Sarasota Radiation and Medical Oncology Center, Sarasota,  Florida,  34233,  United States
      Shands Cancer Center at the University of Florida Health Science Center, Gainesville,  Florida,  32610-0385,  United States
      Tallahassee Memorial Hospital, Tallahassee,  Florida,  32308,  United States
      University of Miami Sylvester Cancer Center, Miami,  Florida,  33136,  United States
Georgia
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States
      Medical Center/John B. Amos Community Cancer Center, Columbus,  Georgia,  31901,  United States
      Regional Radiation Oncology Center at Rome, Rome,  Georgia,  30165,  United States
      Winship Cancer Institute of Emory University, Atlanta,  Georgia,  30322,  United States
Hawaii
      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States
Illinois
      Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood,  Illinois,  60153,  United States
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States
      CCOP - Scott and White Hospital, Peoria,  Illinois,  61602,  United States
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States
      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068,  United States
      Methodist Medical Center of Illinois, Peoria,  Illinois,  61636,  United States
      Northwest Community Hospital, Arlington Heights,  Illinois,  60005,  United States
      Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago,  Illinois,  60611-3013,  United States
Indiana
      Ball Memorial Hospital Cancer Center, Muncie,  Indiana,  47303-3499,  United States
      Bloomington Hospital, Bloomington,  Indiana,  47402,  United States
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States
      Community Regional Cancer Care, Indianapolis,  Indiana,  46219,  United States
      Methodist Cancer Center at Methodist Hospital, Indianapolis,  Indiana,  46206-1367,  United States
      St. John's Cancer Center at St. John's Medical Center, Anderson,  Indiana,  46016,  United States
      Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis,  Indiana,  46202,  United States
Iowa
      Wendt Regional Cancer Center of Finley Hospital, Dubuque,  Iowa,  52001,  United States
Kentucky
      Cancer Center at Lexington Clinic, Lexington,  Kentucky,  40504,  United States
      Central Baptist Hospital, Lexington,  Kentucky,  40503,  United States
      James Graham Brown Cancer Center at University of Louisville, Louisville,  Kentucky,  40202,  United States
      Louisville Radiation Oncology Center at Caritas Regional Cancer Center, Louisville,  Kentucky,  40215,  United States
      Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington,  Kentucky,  40536-0293,  United States
      Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County, Madisonville,  Kentucky,  42431,  United States
      St. Elizabeth Medical Center, Edgewood,  Kentucky,  41017,  United States
Louisiana
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States
      Mary Bird Perkins Cancer Center, Baton Rouge,  Louisiana,  70809,  United States
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112-2699,  United States
Maine
      Maine Medical Center, Portland,  Maine,  04102,  United States
Maryland
      Anne Arundel Oncology Center, Annapolis,  Maryland,  21401,  United States
      Greater Baltimore Medical Center and Cancer Center, Baltimore,  Maryland,  21204,  United States
      Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore,  Maryland,  21201,  United States
      Harbor Hospital Center, Baltimore,  Maryland,  21215-1290,  United States
      Peninsula Regional Medical Center, Salisbury,  Maryland,  21801,  United States
      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States
      Sinai Hospital of Baltimore, Baltimore,  Maryland,  21215,  United States
      St. Agnes Cancer Center, Baltimore,  Maryland,  21229,  United States
Massachusetts
      Cancer Research Center at Boston Medical Center, Boston,  Massachusetts,  02118,  United States
      Cape Cod Hospital, Hyannis,  Massachusetts,  02601,  United States
      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02114,  United States
      NSMC Cancer Center, Peabody,  Massachusetts,  01960,  United States
      Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain,  Massachusetts,  02130,  United States
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201,  United States
      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States
      CCOP - Michigan Cancer Research Consortium, Ann Arbor,  Michigan,  48106,  United States
      Hurley Medical Center, Flint,  Michigan,  48503,  United States
      Josephine Ford Cancer Center at Henry Ford Hospital, Detroit,  Michigan,  48202,  United States
      Marquette General Hospital, Marquette,  Michigan,  49855,  United States
      McLaren Regional Cancer Center, Flint,  Michigan,  48532-3685,  United States
      MidMichigan Medical Center - Midland, Midland,  Michigan,  48670,  United States
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0010,  United States
      William Beaumont Hospital - Royal Oak, Royal Oak,  Michigan,  48073,  United States
      William Beaumont Hospital - Troy, Troy,  Michigan,  48085,  United States
Minnesota
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States
      Fairview University Medical Center - University Campus, Minneapolis,  Minnesota,  55455,  United States
      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905-0001,  United States
Missouri
      Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States
      Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia,  Missouri,  65203,  United States
      Siteman Cancer Center, St. Louis,  Missouri,  63110,  United States
      St. Louis University Hospital Cancer Center, Saint Louis,  Missouri,  63110-0250,  United States
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States
Nebraska
      CCOP - Missouri Valley Cancer Consortium, Omaha,  Nebraska,  68106,  United States
      Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha,  Nebraska,  68114-4199,  United States
      UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha,  Nebraska,  68198-7521,  United States
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States
      Comprehensive Cancer Centers of Nevada, Las Vegas,  Nevada,  89109,  United States
New Hampshire
      Elliot Regional Cancer Center, Manchester,  New Hampshire,  03103,  United States
      Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon,  New Hampshire,  03756-0002,  United States
New Jersey
      Associated Radiologists, P.A., Warren,  New Jersey,  07059,  United States
      Atlantic City Medical Center, Pomona,  New Jersey,  08240,  United States
      Cancer Institute of New Jersey, New Brunswick,  New Jersey,  08903,  United States
      Community Medical Center, Toms River,  New Jersey,  08755,  United States
      Fox Chase Cancer Center at St. Francis Medical Center, Trenton,  New Jersey,  08629,  United States
      Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Mount Holly,  New Jersey,  08060,  United States
      John F. Kennedy Medical Center, Edison,  New Jersey,  08818,  United States
      Medical Center of Princeton, Princeton,  New Jersey,  08540,  United States
      Monmouth Medical Center, Long Branch,  New Jersey,  07740-6395,  United States
      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112,  United States
      South Jersey Regional Cancer Center, Millville,  New Jersey,  08332,  United States
      Trinitas Hospital - Jersey Street Campus, Elizabeth,  New Jersey,  07201,  United States
      Valley Hospital, Ridgewood,  New Jersey,  07450,  United States
      Veterans Affairs Medical Center - East Orange, East Orange,  New Jersey,  07019,  United States
New Mexico
      Radiation Oncology Associates of Albuquerque, Albuquerque,  New Mexico,  87109,  United States
New York
      Beth Israel Medical Center - Philipps Ambulatory Care Center, New York,  New York,  10003,  United States
      Cancer Center of Albany Medical Center, Albany,  New York,  12208,  United States
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., East Syracuse,  New York,  13057,  United States
      Champlain Valley Physicians Hospital Medical Center, Plattsburgh,  New York,  12901-1490,  United States
      Finger Lakes Radiation Oncology Center, Clifton Springs,  New York,  14432,  United States
      Herbert Irving Comprehensive Cancer Center at Columbia University, New York,  New York,  10032,  United States
      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States
      New York Methodist Hospital, Brooklyn,  New York,  11215,  United States
      Riverhill Radiation Oncology, Yonkers,  New York,  10701,  United States
      SUNY Downstate Medical Center, Brooklyn,  New York,  11203,  United States
North Carolina
      Batte Cancer Center at Northeast Medical Center, Concord,  North Carolina,  28025,  United States
      CCOP - Southeast Cancer Control Consortium, Winston Salem,  North Carolina,  27104-4241,  United States
      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1082,  United States
      Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina, Greenville,  North Carolina,  27835-6028,  United States
      Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill,  North Carolina,  27599-7295,  United States
North Dakota
      Trinity Cancer Care Center, Minot,  North Dakota,  58701,  United States
Ohio
      Akron City Hospital, Akron,  Ohio,  44304,  United States
      Akron General Medical Center, Akron,  Ohio,  44302,  United States
      Arthur G. James Cancer Hospital - Ohio State University, Columbus,  Ohio,  43210-1240,  United States
      Cancer Center at Christ Hospital, Cincinnati,  Ohio,  45219,  United States
      CCOP - Columbus, Columbus,  Ohio,  43206,  United States
      CCOP - Dayton, Dayton,  Ohio,  45429,  United States
      CCOP - Toledo Community Hospital, Toledo,  Ohio,  43623-3456,  United States
      Charles M. Barrett Cancer Center at University Hospital, Cincinnati,  Ohio,  45219,  United States
      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195,  United States
      Ireland Cancer Center, Cleveland,  Ohio,  44106-5065,  United States
      Parma Community General Hospital, Parma,  Ohio,  44129,  United States
      University Hospitals of Cleveland, Cleveland,  Ohio,  44106,  United States
Oklahoma
      CCOP - Oklahoma, Tulsa,  Oklahoma,  74136,  United States
      Frank C. Love Cancer Institute at St. Anthony Hospital, Oklahoma City,  Oklahoma,  73102,  United States
      Oklahoma University Medical Center, Oklahoma City,  Oklahoma,  73104,  United States
      St. John Health System, Tulsa,  Oklahoma,  74104,  United States
Oregon
      CCOP - Columbia River Oncology Program, Portland,  Oregon,  97225,  United States
Pennsylvania
      Abington Memorial Hospital, Abington,  Pennsylvania,  19001,  United States
      Abramson Cancer Center at University of Pennsylvania Medical Center, Philadelphia,  Pennsylvania,  19104-4283,  United States
      Albert Einstein Cancer Center, Philadelphia,  Pennsylvania,  19141-3098,  United States
      Allegheny General Hospital, Pittsburgh,  Pennsylvania,  15212,  United States
      CCOP - MainLine Health, Wynnewood,  Pennsylvania,  19096,  United States
      Dale and Frances Hughes Cancer Center, East Stroudsburg,  Pennsylvania,  18301,  United States
      Delaware County Memorial Hospital, Drexel Hill,  Pennsylvania,  19026,  United States
      Fox Chase Cancer Center, Philadelphia,  Pennsylvania,  19111,  United States
      Geisinger Medical Center, Danville,  Pennsylvania,  17822-2001,  United States
      Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh,  Pennsylvania,  15236,  United States
      John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown,  Pennsylvania,  18105,  United States
      Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia,  Pennsylvania,  19107-5541,  United States
      Mercy Fitzgerald Hospital, Darby,  Pennsylvania,  19023,  United States
      Mercy Hospital Cancer Center - Scranton, Scranton,  Pennsylvania,  18501,  United States
      Mercy Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15219,  United States
      Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033-0850,  United States
      Radiation Therapy Oncology Group, Philadelphia,  Pennsylvania,  19107,  United States
      Reading Hospital and Medical Center, Reading,  Pennsylvania,  19612-6052,  United States
      St. Luke's Hospital Cancer Center, Bethlehem,  Pennsylvania,  18015,  United States
      Veterans Affairs Medical Center - Philadelphia, Philadelphia,  Pennsylvania,  19104,  United States
      Wellspan Health - York Cancer Center, York,  Pennsylvania,  17403,  United States
      Western Pennsylvania Hospital, Pittsburgh,  Pennsylvania,  15224,  United States
      Wilkes-Barre General Hospital, Wilkes Barre,  Pennsylvania,  18764-0001,  United States
Rhode Island
      Roger Williams Medical Center, Providence,  Rhode Island,  02908-4735,  United States
South Carolina
      CCOP - Greenville, Greenville,  South Carolina,  29615,  United States
      CCOP - Upstate Carolina, Spartanburg,  South Carolina,  29303,  United States
South Dakota
      Rapid City Regional Hospital, Rapid City,  South Dakota,  57709,  United States
Tennessee
      Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center, Nashville,  Tennessee,  37232-5671,  United States
      West Tennessee Cancer Center at Jackson-Madison County General Hospital, Jackson,  Tennessee,  38301,  United States
Texas
      Arlington Cancer Center, Arlington,  Texas,  76012,  United States
      Harrington Cancer Center, Amarillo,  Texas,  79106,  United States
      Joe Arrington Cancer Research and Treatment Center, Lubbock,  Texas,  79410-1894,  United States
      University of Texas - MD Anderson Cancer Center, Houston,  Texas,  77030-4009,  United States
      University of Texas Health Science Center at San Antonio, San Antonio,  Texas,  78284-7811,  United States
      University of Texas Medical Branch, Galveston,  Texas,  77555-0209,  United States
      Wilford Hall Medical Center, Lackland Air Force Base,  Texas,  78236-5300,  United States
Utah
      Dixie Regional Medical Center, Saint George,  Utah,  84770,  United States
      LDS Hospital, Salt Lake City,  Utah,  84143,  United States
      University of Utah Health Sciences Center, Salt Lake City,  Utah,  84132,  United States
      Utah Valley Regional Medical Center - Provo, Provo,  Utah,  84604,  United States
Vermont
      Green Mountain Oncology Group, Bennington,  Vermont,  05201,  United States
      Vermont Cancer Center at University of Vermont, Burlington,  Vermont,  05405-0075,  United States
Virginia
      Bon Secours - St. Mary's Hospital, Richmond,  Virginia,  23226,  United States
      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States
      Massey Cancer Center at Virginia Commonwealth University, Richmond,  Virginia,  23298-0058,  United States
      Naval Medical Center, Portsmouth, Portsmouth,  Virginia,  23708-2197,  United States
      RMH Regional Cancer Center, Harrisonburg,  Virginia,  22801,  United States
Washington
      Cancer Institute at Virginia Mason Medical Center, Seattle,  Washington,  98111,  United States
      Deaconess Medical Center, Spokane,  Washington,  99204,  United States
      University Cancer Center at University of Washington Medical Center, Seattle,  Washington,  98195-6043,  United States
      Yakima Valley Memorial Hospital, Yakima,  Washington,  98902,  United States
West Virginia
      Schiffler Cancer Center at Wheeling Hospital, Wheeling,  West Virginia,  26003,  United States
Wisconsin
      All Saints Cancer Center at All Saints Healthcare, Racine,  Wisconsin,  53405,  United States
      CCOP - Marshfield Clinic Research Foundation, Marshfield,  Wisconsin,  54449,  United States
      CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay,  Wisconsin,  54301,  United States
      Columbia Hospital, Milwaukee,  Wisconsin,  53211,  United States
      Community Memorial Hospital, Menomonee Falls,  Wisconsin,  53051,  United States
      Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse,  Wisconsin,  54601,  United States
      Marshfield Clinic, Marshfield,  Wisconsin,  54449,  United States
      Medical College of Wisconsin Cancer Center, Milwaukee,  Wisconsin,  53226,  United States
      Southern Wisconsin Radiotherapy Center, Madison,  Wisconsin,  53713,  United States
      St. Luke's Medical Center, Milwaukee,  Wisconsin,  53215,  United States
      St. Vincent Hospital, Green Bay,  Wisconsin,  54307-3508,  United States
      University of Wisconsin Comprehensive Cancer Center, Madison,  Wisconsin,  53792,  United States
      Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee,  Wisconsin,  53295,  United States
      Waukesha Memorial Hospital Regional Cancer Center, Waukesha,  Wisconsin,  53188,  United States
Canada, Alberta
      Cross Cancer Institute, Edmonton,  Alberta,  T6G 1Z2,  Canada
      Tom Baker Cancer Center - Calgary, Calgary,  Alberta,  T2N 4N2,  Canada
Canada, New Brunswick
      Doctor Leon Richard Oncology Centre, Moncton,  New Brunswick,  E1C 8X3,  Canada
      Saint John Regional Hospital, Saint John,  New Brunswick,  E2L 4L2,  Canada
Canada, Newfoundland and Labrador
      Newfoundland Cancer Treatment and Research Foundation, St. Johns,  Newfoundland and Labrador,  A1B 3V6,  Canada
Canada, Nova Scotia
      Nova Scotia Cancer Centre, Halifax,  Nova Scotia,  B3H 1V7,  Canada
Canada, Ontario
      Cancer Care Ontario-London Regional Cancer Centre, London,  Ontario,  N6A 4L6,  Canada
      Kingston Regional Cancer Centre, Kingston,  Ontario,  K7L 5P9,  Canada
      Margaret and Charles Juravinski Cancer Centre, Hamilton,  Ontario,  L8V 5C2,  Canada
      Northeastern Ontario Regional Cancer Centre at Regional Hospital of Sudbury Regional Hospital, Sudbury,  Ontario,  P3E 5J1,  Canada
      Northwestern Ontario Regional Cancer Care, Thunder Bay,  Ontario,  P7B 6V4,  Canada
      Ottawa Regional Cancer Centre, Ottawa,  Ontario,  K1H 1C4,  Canada
      Princess Margaret Hospital, Toronto,  Ontario,  M5G 2M9,  Canada
      Toronto Sunnybrook Regional Cancer Centre, Toronto,  Ontario,  M4N 3M5,  Canada
Canada, Quebec
      Centre Hospitalier de l'Universite de Montreal, Montreal,  Quebec,  H2L 4MI,  Canada
      Centre Hospitalier Universitaire de Quebec, Quebec City,  Quebec,  G1R 2J6,  Canada
      CHUS-Hopital Fleurimont, Fleurimont,  Quebec,  J1H 5N4,  Canada
      McGill University, Montreal,  Quebec,  H2W 1S6,  Canada
Canada, Saskatchewan
      Allan Blair Cancer Centre, Regina,  Saskatchewan,  S4T 7T1,  Canada
      Saskatoon Cancer Centre, Saskatoon,  Saskatchewan,  S7N 4H4,  Canada

Study chairs or principal investigators

Jonathan P.S. Knisely, MD, FRCPC,  Study Chair,  Yale Cancer Center   

Study ID Numbers:  CDR0000069268; RTOG-BR-0118; RTOG-DEV-1006
Record last reviewed:  September 2004
Last Updated:  October 13, 2004
Record first received:  April 9, 2002
ClinicalTrials.gov Identifier:  NCT00033254
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08