Fluconazole |
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Fluconazole Systematic (IUPAC) name 2-(2,4-difluorophenyl)- 1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol Identifiers CAS number 86386-73-4 ATC code D01AC15 J02AC01 PubChem 3365 DrugBank APRD00327 Chemical data Formula C13H12N6F2O Mol. weight 306.271 g/mol Pharmacokinetic data Bioavailability >90% Protein binding 11–12% Metabolism Hepatic 11% Half life 30 hours (range 20-50 hours) Excretion Renal 61–88% Therapeutic considerations Pregnancy ...
Wikipedia - [full article]
Fluconazole Clinical Trials
- A Study to Assess the Effect of Concomitant Administration of Fluconazole on the Clinical Pharmacokinetics of Methadone
ClinicalTrials.gov Identifier: NCT00000788 - Active, not recruiting
Candidiasis; HIV Infections
- A Randomized, Prospective, Double-Blind Study Comparing Fluconazole With Placebo for Primary and Secondary Prophylaxis of Mucosal Candidiasis in HIV-Infected Women
ClinicalTrials.gov Identifier: NCT00000744 - Active, not recruiting
Candidiasis; Candidiasis, esophageal; HIV Infections
- Fluconazole Compared With Voriconazole in Preventing Invasive Fungal Infections in Patients Undergoing Allogeneic Hematopoietic Transplantation
ClinicalTrials.gov Identifier: NCT00075803 - Active, not recruiting
childhood non-Hodgkin's lymphoma; Infection; Leukemia; Lymphoma; myelodysplastic and myeloproliferative diseases
- Fluconazole Pharmacokinetics in Infants
ClinicalTrials.gov Identifier: NCT00514358 - Active, not recruiting
Fungal Infection
- Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
ClinicalTrials.gov Identifier: NCT00003883 - Active, not recruiting
Leukemia; Testicular Cancer; ovarian epithelial cancer; Lymphoma; Breast Cancer; Multiple Myeloma; kidney tumor
- Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia
ClinicalTrials.gov Identifier: NCT00189709 - Active, not recruiting
Candidiasis; Fungemia
- Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients
ClinicalTrials.gov Identifier: NCT00304772 - Recruiting
Candidiasis; Sepsis
- Use of Oral Probiotics as an Adjunctive Therapy to Fluconazole in the Treatment of Yeast Vaginitis
ClinicalTrials.gov Identifier: NCT00479947 - Recruiting
Vaginal Candidiasis
- Nevirapine Levels and Fluconazole
ClinicalTrials.gov Identifier: NCT00309582 - Completed
Nevirapine; Fluconazole; Adverse Event
- Pilot Study to Determine the Feasibility of Fluconazole for Induction Treatment and Suppression of Relapse of Histoplasmosis in Patients with the Acquired Immunodeficiency Syndrome
ClinicalTrials.gov Identifier: NCT00000627 - Completed
HIV Infections; Histoplasmosis
- Efficacy of Single Dose Versus Two Weeks Course of Fluconazole in the Treatment of Oropharyngeal Candidiasis in HIV Infected Individuals in Tanzania
ClinicalTrials.gov Identifier: NCT00553137 - Recruiting
Oropharyngeal Candidiasis
- Safety and Effectiveness of Fluconazole Versus SCH 56592 to Treat Thrush in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00002446 - Completed
Candidiasis, Oral; HIV Infections
- Thai Study: Amphotericin Alone or in Combination with Fluconazole for AIDS-Associated Meningitis
ClinicalTrials.gov Identifier: NCT00145249 - Completed
Cryptococcal Meningitis
- A Study of Fluconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems
ClinicalTrials.gov Identifier: NCT00002339 - Completed
Candidiasis, esophageal; HIV Infections
- Open, Non-comparative Study of Fluconazole in Patients With Coccidioidal Meningitis
ClinicalTrials.gov Identifier: NCT00002010 - Completed
Meningitis; HIV Infections
- A Comparison of SCH 56592 and Fluconazole in the Treatment of Oropharyngeal Candidiasis (OPC) in HIV-Positive Patients
ClinicalTrials.gov Identifier: NCT00002399 - Completed
Candidiasis, Oral; HIV Infections
- Non-Comparative Study of Fluconazole in Patients With Serious Mycoses and Who Cannot Be Treated With Conventional Antifungal Therapy
ClinicalTrials.gov Identifier: NCT00002038 - Completed
Candidiasis; Mycoses; HIV Infections
- A Study to Compare the Use of Fluconazole as Continuous Therapy Versus Periodic Therapy in HIV-Positive Patients with Recurrent Thrush
ClinicalTrials.gov Identifier: NCT00000951 - Completed
Candidiasis, Oral; HIV Infections
- Safety and Antifungal Activity of Recombinant Interferon-gamma 1b (rIFN-gamma 1b) Given with Standard Therapy in Patients with Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00012467 - Active, not recruiting
Meningitis, Cryptococcal; HIV Infections
- A Comparison of the Safety and Effectiveness of Fluconazole or Clotrimazole in the Treatment of Fungal Infections of the Mouth and Throat in Patients with AIDS
ClinicalTrials.gov Identifier: NCT00002282 - Completed
Candidiasis, Oral; HIV Infections
- Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Maintenance Treatment for the Prevention of Relapse of Cryptococcal Meningitis in Patients With Acquired Immunodeficiency Syndrome
ClinicalTrials.gov Identifier: NCT00002074 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Comparison of Fluconazole and Ketoconazole in the Treatment of Fungal Infections of the Throat in Patients with Weakened Immune Systems
ClinicalTrials.gov Identifier: NCT00002304 - Completed
Candidiasis, esophageal; HIV Infections
- Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00002040 - Completed
Meningitis, Cryptococcal; HIV Infections
- An Open, Non-Comparative Study of Intravenous and Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00002077 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections
ClinicalTrials.gov Identifier: NCT00002277 - Completed
Mycoses; HIV Infections
- Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.
ClinicalTrials.gov Identifier: NCT00002132 - Completed
Candidiasis, esophageal; HIV Infections
- Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients with AIDS
ClinicalTrials.gov Identifier: NCT00001017 - Completed
Meningitis, Cryptococcal; HIV Infections
- Multi-center Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00000708 - Completed
Meningitis, Cryptococcal; HIV Infections
- Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)
ClinicalTrials.gov Identifier: NCT00000676 - Completed
Candidiasis; Mycoses; HIV Infections
- Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis
ClinicalTrials.gov Identifier: NCT00004938 - Completed
Sporotrichosis
- Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00002075 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00002068 - Completed
Meningitis, Cryptococcal; HIV Infections
- Pilot Study of Oral Fluconazole in the Treatment of Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00002076 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients Who Have Not Had Success with Amphotericin B
ClinicalTrials.gov Identifier: NCT00002306 - Completed
Meningitis, Cryptococcal; HIV Infections
- Comparative Randomized Study of the Efficacy, Safety, and Toleration of Fluconazole Oral Suspension or Nystatin Oral Suspension in the Treatment of Patients With Oropharyngeal Candidiasis in Association With the Acquired Immunodeficiency Syndrome
ClinicalTrials.gov Identifier: NCT00002112 - Completed
Candidiasis, Oral; HIV Infections
- A Pilot Study of Fluconazole Plus Flucytosine for the Treatment of AIDS Patients With Acute Cryptococcal Meningitis.
ClinicalTrials.gov Identifier: NCT00002113 - Completed
Meningitis, Cryptococcal; HIV Infections
- Kidney Transplants in People with HIV Infection
ClinicalTrials.gov Identifier: NCT00023478 - Active, not recruiting
HIV Infections; End-Stage Renal Disease
- A Study of Fluconazole in the Prevention of Fungal Infections in HIV-Infected Patients Living in Areas Where Fungal Infections Are Common
ClinicalTrials.gov Identifier: NCT00002325 - Completed
Mycoses; HIV Infections; Coccidioidomycosis
- A Study of Fluconazole in the Treatment of Cryptococcal Meningitis in Patients with AIDS
ClinicalTrials.gov Identifier: NCT00002294 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Randomized Double Blind Protocol Comparing Amphotericin B With Flucytosine to Amphotericin B Alone Followed by a Comparison of Fluconazole and Itraconazole in the Treatment of Acute Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00000639 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Comparison of Fluconazole and Amphotericin B in the Treatment of Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00002305 - Completed
Meningitis, Cryptococcal; HIV Infections
- Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine Metabolites
ClinicalTrials.gov Identifier: NCT00000826 - Completed
Bacterial Infections; Mycoses; HIV Infections
- Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis
ClinicalTrials.gov Identifier: NCT00004808 - Completed
Histoplasmosis; Sporotrichosis; Blastomycosis
- Fluconazole in Preventing Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer
ClinicalTrials.gov Identifier: NCT00002533 - Completed
lip and oral cavity cancer; Head and Neck Cancer; Oropharyngeal Cancer
- A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood.
ClinicalTrials.gov Identifier: NCT00163111 - Completed
Candidiasis
- Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants
ClinicalTrials.gov Identifier: NCT00001107 - Completed
Candidiasis
- The Safety and Efficacy of Anidulafungin versus Comparator in Patients with Candidemia and Invasive Candidiasis
ClinicalTrials.gov Identifier: NCT00056368 - Completed
Candidiasis
- Anidulafungin versus Fluconazole in the Treatment of Candidemia
ClinicalTrials.gov Identifier: NCT00058682 - Completed
Candida; Candidiasis
- Comparing the Effectiveness of Fluconazole and a New Medicine (FK463) in Preventing Fungal Infections in Bone Marrow Transplant Patients
ClinicalTrials.gov Identifier: NCT00001937 - Completed
Aspergillosis; Candidiasis; Fungemia; Mycoses
- Safety and Effectiveness of Giving Lamisil to HIV-Positive Subjects With Thrush Who Have Not Responded to Fluconazole Treatment
ClinicalTrials.gov Identifier: NCT00002394 - Completed
Candidiasis, Oral; HIV Infections
- A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients Who Have Not Had Success with Fluconazole
ClinicalTrials.gov Identifier: NCT00001065 - Completed
Candidiasis, Oral; HIV Infections
- A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success with Itraconazole But Not with Fluconazole
ClinicalTrials.gov Identifier: NCT00002341 - Completed
Candidiasis, Oral; HIV Infections
- An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects.
ClinicalTrials.gov Identifier: NCT00002133 - Completed
Candidiasis, Oral; HIV Infections
- Fluconazole Prophylaxis of Thrush in AIDS
ClinicalTrials.gov Identifier: NCT00001542 - Completed
Acquired Immunodeficiency Syndrome; Candidiasis; Oral Candidiasis
- Dexamethasone in Cryptococcal Meningitis
ClinicalTrials.gov Identifier: NCT00000776 - Completed
Meningitis, Cryptococcal; HIV Infections
- A Randomized Study of Daily and Intermittent Prophylactic Regimens for the Prevention of Disseminated Mycobacterium avium Complex (MAC) and Fungal Infections in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002122 - Completed
Mycoses; Mycobacterium avium-intracellulare Infection; HIV Infections
- Blood and Marrow Transplant Clinical Research Network
ClinicalTrials.gov Identifier: NCT00023530 - Completed
Bone Marrow Transplantation; Blood Disease; Hematopoietic Stem Cell Transplantation; Leukemia; Multiple Myeloma; Myelodysplastic Syndromes; ...
- Safety and Effectiveness of Giving L-743,872 to Patients with Thrush That Has Not Been Cured With Fluconazole
ClinicalTrials.gov Identifier: NCT00005920 - Terminated
Candidiasis, Oral; HIV Infections

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