The purpose of this trial is to study genetic and other risk factors that may be important in the development of Parkinson’s disease.

Condition
Parkinson Disease

Further Study Details: 

Expected Total Enrollment:  1800

The Parkinson’s Research: The Organized Genetics Initiative, also known as PROGENI, is a multi-center study involving 900 pairs of brothers and sisters throughout North America who are affected, or possibly affected, with Parkinson’s disease (PD). The goal of the initiative is to study the genetic and other risk factors which may be important in the development of PD.

In order to better understand the genetic factors leading to PD, researchers will study families having 2 or more members diagnosed with PD. Using DNA samples from each participant, researchers hope to identify genes that may cause a person to be at higher risk for developing PD.

Each participant in the study will be asked to complete a family history questionnaire, providing information about the history of PD in the family. Participants also will be asked to discuss the symptoms they have experienced and their responses to PD medications. This information will be used by study personnel to determine further eligibility for the study. Those eligible for further participation will be asked to undergo a study visit at the site closest to their residence, during which they will be asked to complete questionnaires regarding PD symptoms, medical history, places of residence, occupations, mood, mental status, and activity level. A blood sample will be drawn for DNA extraction. The study visit will take about 2 hours.

Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• To be eligible to participate in this study, families must have at least 2 living brothers or sisters affected with, or possibly affected with, Parkinson’s disease, and both affected family members must be willing to participate.

Exclusion Criteria:

• Subjects cannot have participated in any other genetic research project for Parkinson’s disease.

Cheryl A. Halter, MS, CCRC      1-888-830-6299    chalter@iupui.edu

Arizona
      Barrow Neurological Institute, Phoenix,  Arizona,  85013,  United States; Recruiting
California
      Parkinson's & Movement Disorder Institute, Fountain Valley,  California,  92708,  United States; Recruiting
      University of California Irvine, Irvine,  California,  92612,  United States; Recruiting
      California Medical Clinic for Movement Disorders, Oxnard,  California,  93030,  United States; Recruiting
      University of California San Diego, San Diego,  California,  92101,  United States; Recruiting
      University of California San Francisco, San Francisco,  California,  94143,  United States; Recruiting
Colorado
      University of Colorado Health Sciences Center, Denver,  Colorado,  80262,  United States; Recruiting
      Colorado Neurological Institute, Englewood,  Colorado,  80113,  United States; Recruiting
Connecticut
      University of Connecticut, Farmington,  Connecticut,  06030,  United States; Recruiting
      Institute for Neurodegenerative Disorders, New Haven,  Connecticut,  06510,  United States; Recruiting
Florida
      Mayo Clinic Jacksonville, Jacksonville,  Florida,  32224,  United States; Recruiting
      University of Miami, Miami,  Florida,  33124,  United States; Recruiting
      University of South Florida, Tampa,  Florida,  33620,  United States; Recruiting
      Cleveland Clinic Florida, Weston,  Florida,  33331,  United States; Recruiting
Georgia
      Medical College of Georgia, Augusta,  Georgia,  30912,  United States; Recruiting
Illinois
      Northwestern University Medical School, Chicago,  Illinois,  60611,  United States; Recruiting
      University of Chicago, Chicago,  Illinois,  60637,  United States; Recruiting
Indiana
      Indiana University School of Medicine, Indianapolis,  Indiana,  46202,  United States; Recruiting
Iowa
      University of Iowa, Iowa City,  Iowa,  52242,  United States; Recruiting
Kansas
      Kansas University Medical Center, Kansas City,  Kansas,  66160,  United States; Recruiting
Louisiana
      LSU Medical Center, New Orleans,  Louisiana,  70112,  United States; Recruiting
Maryland
      University of Maryland School of Medicine, Baltimore,  Maryland,  21201,  United States; Recruiting
Massachusetts
      Beth Israel Deaconess Medical Center, Boston,  Massachusetts,  02215,  United States; Recruiting
      Brigham & Women's Hospital, Boston,  Massachusetts,  02115,  United States; Recruiting
Michigan
      Clinical Neuroscience Center, West Bloomfield,  Michigan,  48322,  United States; Recruiting
Minnesota
      University of Minnesota Fairview Univ Med Ctr, Minneapolis,  Minnesota,  55406,  United States; Recruiting
Missouri
      Washington University, St. Louis,  Missouri,  63130,  United States; Recruiting
Nebraska
      Creighton University, Omaha,  Nebraska,  68178,  United States; Recruiting
New York
      Albany Medical College, Albany,  New York,  12208,  United States; Recruiting
      Long Island Jewish Medical Center, New Hyde Park,  New York,  11040,  United States; Recruiting
      Mount Sinai Medical Center, New York,  New York,  10029,  United States; Recruiting
      Columbia-Presbyterian Medical Center, New York,  New York,  10032,  United States; Recruiting
      Columbia-Presbyterian Medical Center, New York,  New York,  10032,  United States; Recruiting
      Beth Israel Medical Center, New York,  New York,  10003,  United States; Recruiting
      University of Rochester Medical Center, Rochester,  New York,  14642,  United States; Recruiting
North Carolina
      Wake Forest University School of Medicine, Winston Salem,  North Carolina,  27157,  United States; Recruiting
Ohio
      University of Cincinnati Medical Center, Cincinnati,  Ohio,  45267,  United States; Recruiting
      Ohio State University, Columbus,  Ohio,  43210,  United States; Recruiting
      Medical College of Ohio, ,, Toledo,  Ohio,  43614,  United States; Recruiting
Oregon
      Oregon Health & Science University, Portland,  Oregon,  97239,  United States; Recruiting
Rhode Island
      Brown University, Pawtucket,  Rhode Island,  62912,  United States; Recruiting
Tennessee
      University of Tennessee-Memphis, Memphis,  Tennessee,  38163,  United States; Recruiting
Texas
      UT Southwestern Medical Center, Dallas,  Texas,  75390,  United States; Recruiting
      Baylor College of Medicine, Houston,  Texas,  77030,  United States; Recruiting
      Scott & White Hospital/Texas A&M University, Temple,  Texas,  76508,  United States; Recruiting
Wisconsin
      Medical College of Wisconsin, Milwaukee,  Wisconsin,  53226,  United States; Recruiting
Canada, Alberta
      University of Calgary, Calgary,  Alberta,  Canada; Recruiting
      University of Alberta, Edmonton,  Alberta,  Canada; Recruiting
Canada, Ontario
      London Health Sciences Center, London,  Ontario,  Canada; Recruiting
      Ottawa Civic Hospital, Ottawa,  Ontario,  Canada; Recruiting
      Toronto Western Hospital, Toronto,  Ontario,  Canada; Recruiting
Canada, Quebec
      Hotel-Dieu Hospital-CHUM, Montreal,  Quebec,  Canada; Recruiting
      McGill Centre for Studies in Aging, Verdun,  Quebec,  Canada; Recruiting
Puerto Rico
      University of Puerto Rico School of Medicine, San Juan,  Puerto Rico; Recruiting

Study chairs or principal investigators

Tatiana Foroud, Ph.D.,  Principal Investigator,  Indiana University   

Study ID Numbers:  R01NS37167
Record last reviewed:  December 2004
Last Updated:  December 7, 2004
Record first received:  June 22, 2004
ClinicalTrials.gov Identifier:  NCT00086073
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08