Primary Objective:

- To determine the toxicity profile and tolerability of alemtuzumab (Campath) when administered in combination with CHOP chemotherapy (C-CHOP) in patients with T-cell, Null-cell and NK-cell lymphomas.

Secondary Objectives:

• To evaluate response rate, overall survival and disease-free survival in patients with T-cell, Null-cell and NK-cell lymphomas treated with Campath + CHOP chemotherapy.
• To assess the incidence of CMV reactivation in patients with these lymphomas treated with the Campath + CHOP combination.
• To determine features which might be predictive of resistance to treatment or predictive of relapse, including the absence of GPI-linked proteins.

Inclusion Criteria:

• Patients must have a diagnosis of non-B-cell, non-Hodgkin’s lymphoma (including T-cell, Null-cell, or NK-cell lymphoma, but excluding lymphoblastic lymphoma)
• Stage II, III, or IV disease requiring chemotherapy
• At least one site of measurable disease, 1.5 cm in diameter or greater
• Age > or = 18 years
• Absolute granulocyte count of at least 1500 cells/mm3, unless neutropenia is due to marrow infiltration by the tumor
• Platelet count of at least 100,000 cells/mm3 unless thrombocytopenia is due to marrow infiltration by tumor
• Creatinine less than 2 x ULN
• Total bilirubin less than 2 x ULN (dose reduce vincristine and adriamycin required for bilirubin > 1.2 mg/dL)
• Echo or MUGA documenting a normal ejection fraction prior to chemotherapy
• Able to give informed consent

Exclusion Criteria:

• Known CNS involvement
• Known HIV disease
• Patients who are pregnant or nursing
• Any factor which might limit the patient’s ability to provide informed consent
• Life expectancy < 3 months
• Patients who are unwilling to agree to use an effective means of birth control while on treatment