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Effects of Dynorphin 1-13 on Heroin Addiction - 1 - Article


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Clinical Trial: Effects of Dynorphin 1-13 on Heroin Addiction - 1

This study has been completed.

Sponsors and Collaborators: National Institute on Drug Abuse (NIDA)
University of Minnesota
Information provided by: National Institute on Drug Abuse (NIDA)

Purpose

The purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.

Condition Treatment or Intervention Phase
Opioid-Related Disorders
Substance Withdrawal Syndrome
  Drug: Dynorphin 1 - 13
 Phase II

MedlinePlus related topics:  Drug Abuse;   Prescription Drug Abuse

Study Type: Interventional
Study Design: Treatment, Double-Blind, Placebo Control

Official Title: Effects of Dynorphin 1-13 on Heroin Addiction

Further Study Details: 

Study start: August 1994;  Study completion: August 1995

Randomized double blinded study of the effects of a single IV dose of dynorphin A 1-13 on heroin withdrawal in human opiate addicts

Eligibility

Ages Eligible for Study:  18 Years   -   55 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

opiate addict between the ages of 18-55

Exclusion Criteria:

Regular abuse of other drugs, unstable medical conditions


Location Information


Minnesota
      U of Minnesota School of Medicine, Minneapolis,  Minnesota,  55415,  United States

Study chairs or principal investigators

Paul Pentel, M.D.,  Principal Investigator,  University of Minnesota   

More Information

Publications

Specker S, Wananukul W, Hatsukami D, Nolin K, Hooke L, Kreek MJ, Pentel PR. Effects of dynorphin A(1-13) on opiate withdrawal in humans. Psychopharmacology (Berl). 1998 Jun;137(4):326-32.

Study ID Numbers:  NIDA-08067-1; R01-08067-1
Record last reviewed:  August 1995
Last Updated:  November 18, 2004
Record first received:  September 20, 1999
ClinicalTrials.gov Identifier:  NCT00000244
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

Resources



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November 30, 2009


Page Updated: October 3, 2005
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