This is a world wide to study to evaluate the remission and joint damage in subjects treated with Abatacept in addition to Methotrexate versus subjects who receive Methotrexate along with a placebo.

Condition	Intervention	Phase
Rheumatoid Arthritis	Drug: Abatacept	Phase III

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Diagnosis of RA <2 years never received treatment with Methotrexte, erosions noted on x-ray
• CRP > - 8.0 mg/L
• Rheumatoid Factor or Anti CCP Positive

Exclusion Criteria:

• Women and Men who are not willing to use birth control
• Diagnosed with other rheumatic disease
• History of cancer within 5 years
• Active tuberculosis
• Treatment with another investigation drug within 28 days
• Active bacterial or viral infection

Please refer to this study by ClinicalTrials.gov identifier  NCT00122382

BMS Call Center      1-866-892-1BMS  Ext. 183 
BMS Call Center Outside the US and Canada      1-215-347-4079  Ext. 183 

Alabama
      Local Institution, Huntsville,  Alabama,  United States; Recruiting
      Local Institution, Mobile,  Alabama,  United States; Not yet recruiting
California
      Local Institution, Huntington Beach,  California,  United States; Not yet recruiting
      Local Institution, Los Angeles,  California,  United States; Not yet recruiting
Colorado
      Local Institution, Colorado Springs,  Colorado,  United States; Not yet recruiting
Connecticut
      Local Institution, Bridgeport,  Connecticut,  United States; Not yet recruiting
Florida
      Local Institution, Ft. Lauderdale,  Florida,  United States; Not yet recruiting
Idaho
      Local Institution, Nampa,  Idaho,  United States; Not yet recruiting
Indiana
      Local Institution, Evansville,  Indiana,  United States; Not yet recruiting
      Local Institution, Indianapolis,  Indiana,  United States; Not yet recruiting
Louisiana
      Local Institution, New Orleans,  Louisiana,  United States; Not yet recruiting
      Local Institution, Slidell,  Louisiana,  United States; Not yet recruiting
Maryland
      Local Institution, Columbia,  Maryland,  United States; Not yet recruiting
      Local Institution, Cumberland,  Maryland,  United States; Not yet recruiting
      Local Institution, Hagerstown,  Maryland,  United States; Not yet recruiting
Nebraska
      Local Institution, Lincoln,  Nebraska,  United States; Not yet recruiting
New York
      Local Institution, Binghamton,  New York,  United States; Not yet recruiting
North Carolina
      Local Institution, Charleotte,  North Carolina,  United States; Not yet recruiting
      Local Institution, Durham,  North Carolina,  United States; Not yet recruiting
      Local Institution, Greenville,  North Carolina,  United States; Not yet recruiting
      Local Institution, Statesville,  North Carolina,  United States; Not yet recruiting
Oklahoma
      Local Institution, Oklahoma City,  Oklahoma,  United States; Not yet recruiting
Pennsylvania
      Local Institution, Duncansville,  Pennsylvania,  United States; Not yet recruiting
      Local Institution, Willow Grove,  Pennsylvania,  United States; Not yet recruiting
South Carolina
      Local Institution, Charelston,  South Carolina,  United States; Not yet recruiting
Texas
      Local Institution, Austin,  Texas,  United States; Not yet recruiting
Virginia
      Local Institution, Arlington,  Virginia,  United States; Not yet recruiting
Australia, Queensland
      Local Institution, Cairns,  Queensland,  Australia; Not yet recruiting
Australia, Victoria
      Local Institution, Clayton,  Victoria,  Australia; Not yet recruiting
      Local Institution, Malvern,  Victoria,  Australia; Not yet recruiting
Australia, Western Australia
      Local Institution, Perth,  Western Australia,  Australia; Not yet recruiting
Belgium
      Local Institution, BRUXELLES,  Belgium; Not yet recruiting
      Local Institution, Gent,  Belgium; Not yet recruiting
      Local Institution, Leuven,  Belgium; Not yet recruiting
Brazil
      Local Institution, Sao Paulo,  Brazil; Not yet recruiting
Brazil, Distrito Federal
      Local Institution, Brasilia,  Distrito Federal,  Brazil; Not yet recruiting
Brazil, Goias
      Local Institution, Goiania,  Goias,  Brazil; Not yet recruiting
Brazil, Parana
      Local Institution, Curitiba,  Parana,  Brazil; Not yet recruiting
Brazil, Rio De Janeiro
      Local Institution, Rio de Janeiro - RJ,  Rio De Janeiro,  Brazil; Not yet recruiting
Brazil, Rio Grande Do Sul
      Local Institution, Porto Alegre,  Rio Grande Do Sul,  Brazil; Not yet recruiting
Canada, Alberta
      Local Institution, Edmonton,  Alberta,  Canada; Not yet recruiting
Canada, British Columbia
      Local Institution, Vancouver,  British Columbia,  Canada; Not yet recruiting
      Local Institution, Victoria,  British Columbia,  Canada; Not yet recruiting
Canada, New Brunswick
      Local Institution, Fredericton,  New Brunswick,  Canada; Not yet recruiting
Canada, Newfoundland and Labrador
      Local Institution, St. John''''s,  Newfoundland and Labrador,  Canada; Not yet recruiting
Canada, Ontario
      Local Institution, Kitchener,  Ontario,  Canada; Not yet recruiting
      Local Institution, London,  Ontario,  Canada; Not yet recruiting
      Local Institution, Toronto,  Ontario,  Canada; Not yet recruiting
Canada, Quebec
      Local Institution, Fleurimont,  Quebec,  Canada; Not yet recruiting
      Local Institution, Montreal,  Quebec,  Canada; Not yet recruiting
      Local Institution, Ste Foy,  Quebec,  Canada; Not yet recruiting
Canada, Saskatchewan
      Local Institution, Saskatoon,  Saskatchewan,  Canada; Not yet recruiting
Czech Republic
      Local Institution, PRAGUE 2,  Czech Republic; Not yet recruiting
France
      Local Institution, Dijon,  France; Not yet recruiting
      Local Institution, Montpellier Cedex 5,  France; Not yet recruiting
      Local Institution, Nice Cedex 03,  France; Not yet recruiting
      Local Institution, Paris Cedex 14,  France; Not yet recruiting
      Local Institution, Strasbourg Cedex,  France; Not yet recruiting
      Local Institution, Toulouse,  France; Not yet recruiting
Ireland
      Local Institution, Cork,  Ireland; Not yet recruiting
      Local Institution, Dublin,  Ireland; Not yet recruiting
Ireland, Dublin
      Local Institution, Dublin 9,  Dublin,  Ireland; Not yet recruiting
Italy
      Local Institution, Jesi (Ancona),  Italy; Not yet recruiting
      Local Institution, Milano,  Italy; Not yet recruiting
      Local Institution, Pavia,  Italy; Not yet recruiting
Korea, Republic of
      Local Institution, Anyang,  Korea, Republic of; Not yet recruiting
      Local Institution, Daegu,  Korea, Republic of; Not yet recruiting
      Local Institution, Daejeon,  Korea, Republic of; Not yet recruiting
      Local Institution, Seoul,  Korea, Republic of; Not yet recruiting
Mexico
      Local Institution, Aguascalientes,  Mexico; Not yet recruiting
      Local Institution, Chihuahua,  Mexico; Not yet recruiting
Mexico, Distrito Federal
      Local Institution, Guadalajara,  Distrito Federal,  Mexico; Not yet recruiting
      Local Institution, Mexico, D.F.,  Distrito Federal,  Mexico; Not yet recruiting
Mexico, Estado De Mexico
      Local Institution, Metepec,  Estado De Mexico,  Mexico; Not yet recruiting
Mexico, Guanajuato
      Local Institution, Leon,  Guanajuato,  Mexico; Not yet recruiting
Mexico, Jalisco
      Local Institution, Gadalajara,  Jalisco,  Mexico; Not yet recruiting
Mexico, Michioacan
      Local Institution, Morelia,  Michioacan,  Mexico; Not yet recruiting
Mexico, Morelos
      Local Institution, Cuernavaca,  Morelos,  Mexico; Not yet recruiting
Netherlands
      Local Institution, Leeuwarden,  Netherlands; Not yet recruiting
      Local Institution, Nijmegen,  Netherlands; Not yet recruiting
Poland
      Local Institution, Poznan,  Poland; Not yet recruiting
      Local Institution, Warszawa,  Poland; Not yet recruiting
Puerto Rico
      Local Institution, Ponce,  Puerto Rico; Not yet recruiting
Russian Federation
      Local Institution, Moscow,  Russian Federation; Not yet recruiting
South Africa, Free State
      Local Institution, Bloemfontein,  Free State,  South Africa; Not yet recruiting
South Africa, Gauteng
      Local Institution, Muckleneuk,  Gauteng,  South Africa; Not yet recruiting
      Local Institution, Pretoria,  Gauteng,  South Africa; Not yet recruiting
South Africa, Kwa Zulu Natal
      Local Institution, Berea,  Kwa Zulu Natal,  South Africa; Not yet recruiting
South Africa, Western Cape
      Local Institution, Cape Town,  Western Cape,  South Africa; Not yet recruiting
      Local Institution, Panoram,  Western Cape,  South Africa; Not yet recruiting
Spain
      Local Institution, A Coruna,  Spain; Not yet recruiting
      Local Institution, Oviedo,  Spain; Not yet recruiting
      Local Institution, Santander,  Spain; Not yet recruiting
      Local Institution, Sevilla,  Spain; Not yet recruiting
United Kingdom, Durham
      Local Institution, Newcastle,  Durham,  United Kingdom; Not yet recruiting
United Kingdom, Greater London
      Local Institution, London,  Greater London,  United Kingdom; Not yet recruiting
United Kingdom, Greater Manchester
      Local Institution, Manchester,  Greater Manchester,  United Kingdom; Not yet recruiting
United Kingdom, Lanarkshire
      Local Institution, Glasgow,  Lanarkshire,  United Kingdom; Not yet recruiting
United Kingdom, North Yorkshire
      Local Institution, Leeds,  North Yorkshire,  United Kingdom; Not yet recruiting
United Kingdom, Somerset
      Local Institution, Bath,  Somerset,  United Kingdom; Not yet recruiting

Study ID Numbers:  IM101-023
Record last reviewed:  July 2005
Last Updated:  July 25, 2005
Record first received:  July 21, 2005
ClinicalTrials.gov Identifier:  NCT00122382
Health Authority: United States: Food and Drug Administration
ClinicalTrials.gov processed this record on 2005-07-26