Clinical Trial: The Effects of Overfeeding on Obesity-Prone (OP) and Obesity-Resistant (OR) Women

This study is currently recruiting patients.

Sponsored by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)


This is a longitudinal cohort study of how the responses to a 3 day period of controlled overfeeding relate to subsequent weight gain. We hypothesize that thin individuals are resistant to weight gain because they respond to periods of overfeeding by increasing fat oxidation, reducing food intake, and increasing physical activity relative to those who gain weight over time.

weight gain

MedlinePlus related topics:  Obesity

Study Type: Observational
Study Design: Natural History, Longitudinal, Defined Population, Prospective Study

Further Study Details: 

Expected Total Enrollment:  80

Study start: October 2003;  Expected completion: June 2008


Ages Eligible for Study:  25 Years   -   35 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers


  • Half of the subjects will be women, half will be men,
  • age 25-35,
  • a range of BMI's from 19-27, for the 'thin subjects' there should be no 1st degree relatives with a BMI>30.
  • Subjects should not engage in planned physical activity more than 3 hrs per week.
  • For the obesity prone group there should be at least 1 1st degree relative with a BMI>30.

Location and Contact Information

      University of Colorado Health Sciences Center, Denver,  Colorado,  80262,  United States; Recruiting
Sandra VonKaenel, BS  303-315-9005 
Daniel H Bessesen, MD  (303) 436-5910 
Daniel H Bessesen, MD,  Principal Investigator

More Information

Study ID Numbers:  OVOPOB
Record last reviewed:  November 2004
Last Updated:  November 12, 2004
Record first received:  November 12, 2003 Identifier:  NCT00072917
Health Authority: United States: Federal Government processed this record on 2005-04-08

Cache Date: April 9, 2005