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Sensory Re-Training Following Facial Surgery for Correction of Facial Skeletal Disharmony - Article


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Clinical Trial: Sensory Re-Training Following Facial Surgery for Correction of Facial Skeletal Disharmony

This study is currently recruiting patients.

Sponsored by: National Institute of Dental and Craniofacial Research (NIDCR)
Information provided by: National Institute of Dental and Craniofacial Research (NIDCR)

Purpose

The purpose of this study is to determine whether facial exercises in conjunction with opening exercises routinely provided after facial surgery to correct a facial skeletal disharmony will shorten the time until a patient receives no unpleasant or negative facial sensation.

Condition Treatment or Intervention Phase
Mandibular Advancement
 Procedure: Sensory Re-training
Phase IV

MedlinePlus consumer health information 

Study Type: Interventional
Study Design: Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study

Official Title: Sensory Re-Training Following Orthognathic Surgery

Further Study Details: 

Expected Total Enrollment:  220

Study start: December 2001;  Expected completion: May 2006

Abnormal facial sensation has a negative impact on patients' oral behaviors and may adversely affect a patient's quality of life if the altered sensation persists. Many patients with abnormal sensations retain some sensory function and do not develop chronic pain, and for those individuals there are currently no evidence-based noninvasive therapies. The goal of this project is to evaluate sensory re-training, a rehabilitative therapy that offers significant potential for patients who experience impaired sensory function regardless of the cause. This behavioral therapy approach has been used with substantial clinical success with hand injury patients since the 1970s. Re-training appears to enhance central reorganization of impulses from an injured sensory nerve to the cerebral cortex so that the altered sensory signals can be interpreted and translated into functionally meaningful motor functions. Sensory re-training will be compared to a placebo jaw-opening exercise in a single blind, randomized two-arm parallel group stratified block clinical trial, using orthognathic surgery patients as subjects. Orthognathic surgery patients offer an uncompromised model for the evaluation of new rehabilitative therapies. These healthy individuals, treated to correct dentofacial deformity, present for surgery with no neurosensory impairment, but yet routinely experience substantial alterations in facial sensation following the surgical procedure. The effects of sensory re-training will be evaluated using three types of outcomes: patient-centered measures to assess the magnitude of the negative effect of altered sensation after surgery and the recovery time needed to reach little or no negative effect; neurosensory behavior measures to assess the patient's ability to learn alternate cues for touch perception and discrimination; and a conventional neurosensory contact threshold measure to assess the actual deficit. Our primary focus will be on the patient's perception of the negative impact of altered sensation on daily life.

Eligibility

Ages Eligible for Study:  13 Years   -   50 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

  • Developmental dentofacial disharmony
  • Receives mandibular advancement by mandibular osteotomy with or without a maxillary procedure.

Exclusion Criteria:

  • Congenital anomaly or acute trauma affecting the face.
  • Previous facial surgery
  • Pregnant at baseline
  • Inability to follow written English instructions
  • Unwilling to sign informed consent.
  • No altered sensation at one week post-surgery
  • Altered sensation at baseline reported as numbness or unusual feeling.
  • Medical condition associated with systemic neuropathy.

Location and Contact Information

Ceib Phillips      919-966-2763    Ceib_Phillips@dentistry.unc.edu

North Carolina
      School of Dentistry, Chapel Hill,  North Carolina,  27599,  United States; Recruiting
Ceib Phillips, DR  919-966-2763    Ceib_Phillips@dentistry.unc.edu 
Ceib Phillips, Dr,  Principal Investigator

      University Oral and Maxillofacial Surgery, Charlotte,  North Carolina,  28211,  United States; Recruiting
Myron Tucker  704-347-0241    myrontucker@mindspring.com 
David Frost  919-479-0707 
Ceib Phillips,  Principal Investigator

More Information

Study ID Numbers:  NIDCR-13967
Record last reviewed:  October 2004
Last Updated:  October 20, 2004
Record first received:  March 1, 2004
ClinicalTrials.gov Identifier:  NCT00078507
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005


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November 27, 2009



Page Updated: January 17, 2009
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