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How Does Early Age Life Style Affect Bone Strength and General Health at Middle Age? - Article


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Clinical Trial: How Does Early Age Life Style Affect Bone Strength and General Health at Middle Age?

This study is not yet open for patient recruitment.
Verified by Hadassah Medical Organization December 2005

Sponsored by: Hadassah Medical Organization
Information provided by: Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00270608

Purpose

To evaluate the effect of vigorous physical activity versus extremely sedentary life style during young age on the bone mineral density and general health in later life.
Condition Intervention
Bone Diseases
Total Body Fat Percentage
Hypertension
Cardiovascular Diseases
Musculoskeletal Diseases
 Procedure: whole body DEXA scanning

MedlinePlus related topics:  Bone Diseases;   Heart Diseases;   High Blood Pressure;   Vascular Diseases
Genetics Home Reference related topics:  Bone Diseases

Study Type: Observational
Study Design: Natural History, Longitudinal, Defined Population, Retrospective Study

Official Title: How Does Early Age Life Style Affect Bone Strength and General Health at Middle Age? Twenty-Three Year Follow-Up Health Status Comparison of a Sedentary Versus Extremely Physically Active Population From an Early Age

Further study details as provided by Hadassah Medical Organization:

Expected Total Enrollment:  42

Study start: April 2006;  Expected completion: February 2007
Last follow-up: September 2006;  Data entry closure: December 2006

Bone strength and peak bone mass are preliminary determined by genetic factors. Life style, especially exercise, is also considered to have an important effect on bone strength. Bone has the ability to strengthen itself according to Wolff''''s Law. When bone is subjected to strains and/or strain rates higher than the usual, it responds by remodeling, strengthening its architecture. The ability is greatest in young individuals and decreases with age. In the elderly this ability is largely non-existent and bone mass is lost. Whether this loss leads to osteoporosis is largely a function of the peak bone mass achieved before the decline. 11% of males and 44 % of females over 50 suffer from osteoporosis in later life. To what extent vigorous exercising beginning at a young age can increase bone strength is not known.

The purpose of the proposed research is to quantify the effect of life style on bone strength and general health parameters by comparing two male populations, one sedentary and the other that has done demanding physical training: (1) Elite infantry recruits who were inducted into the I.D.F. in Feb 1983, did their basic training at Sanur and were part of the 1983 stress fracture project who completed three years of elite infantry service and continued to serve as combat soldiers in the reserves; (2) Yeshiva students who had profiles of 82 or 97 and received deferment from their military service in 1983 and since then have continued their studies and never served in the army.

21 subjects will be reviewed in each group. Their weight, height, waist girth, resting pulse and blood pressure will be measured. A health questionnaire will be administered. Bone Mineral Density and Bone Mineral Content as well as total body percentage of fat will be calculated using whole body DEXA scanning.

Comparisons:

Group I: 21 males (age 41-44), former elite Israeli infantry soldiers, selected randomly from those recruits who did their infantry basic training at Sanur in Feb. 1983 (all profiled 82 or 97) and completed their military service as combat soldiers will be compared to:

Group II: 21 age-, profile- and ethnically-matched Israeli citizens whose military service was deferred in 1983 because of Torah studies and who did not do army service and were not involved in any kind of physical training.

Eligibility

Ages Eligible for Study:  40 Years   -   45 Years,  Genders Eligible for Study:  Male

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

  • Israeli military profile 82 or 97 at age 17-22

Exclusion Criteria:

  • Israeli military profile less than 82 at age 17-22

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier  NCT00270608

Prof. Charles Milgrom, MD      972 50 787 4401    milgrom@md2.huji.ac.il

Israel
      Hadassah Medical Organization, Jerusalem,  Israel
Arik Tzukert, DMD  00 972 2 6776095    arik@hadassah.org.il 
Hadas Lemberg, PhD  00 972 2 6777572    lhadas@hadassah.org.il 
Prof. Charles Milgrom, MD,  Principal Investigator

Study chairs or principal investigators

Prof. Charles Milgrom, MD,  Principal Investigator,  Hadassah Medical Organization   

More Information

Publications that report results of this study

Milgrom C, Giladi M, Stein M, Kashtan H, Margulies JY, Chisin R, Steinberg R, Aharonson Z. Stress fractures in military recruits. A prospective study showing an unusually high incidence. J Bone Joint Surg Br. 1985 Nov;67(5):732-5.

Study ID Numbers:  12-17.02.06-HMO-CTIL
Last Updated:  December 27, 2005
Record first received:  December 26, 2005
ClinicalTrials.gov Identifier:  NCT00270608
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration
ClinicalTrials.gov processed this record on 2006-01-10


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November 28, 2009



Page Updated: January 17, 2009
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