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Behavior Therapy for Children and Adolescents with Obsessive-Compulsive Disorder (OCD) - Article


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Clinical Trial: Behavior Therapy for Children and Adolescents with Obsessive-Compulsive Disorder (OCD)

This study is no longer recruiting patients.

Sponsored by: National Institute of Mental Health (NIMH)
Information provided by: National Institute of Mental Health (NIMH)

Purpose

The purpose of this study is to evaluate a behavioral treatment program for children and adolescents with OCD and their families. Exposure and Response Prevention (ERP) behavior therapy, in which the patient is gradually exposed to the object or situation that causes anxiety and is taught to refrain from responding in a compulsive manner, is combined with family counseling (Family Treatment Program). This treatment will be compared to Relaxation Training (RT).

OCD is a long-term, often disabling disorder that can cause significant family disruption. ERP is a promising treatment for children with OCD, and it is thought that family participation (through the Family Treatment Program) may be a helpful addition. RT is a common treatment for anxiety.

Patients are assigned randomly (like tossing a coin) to receive either the ERP/Family Treatment Program or RT. Both treatments will be delivered over 12 90-minute outpatient sessions to youngsters and their families. All participants (patients and family members) will be assessed for treatment response each month during treatment, after treatment is finished, and then at 2 follow-up visits over the following 6 months.

A child/adolescent may be eligible for this study if he/she: Has obsessive-compulsive disorder (OCD), is medication-free, and is 8 to 17 years old.

Condition Treatment or Intervention Phase
Obsessive-Compulsive Disorder
 Behavior: Exposure and Response Prevention
 Behavior: Family Treatment Program
 Behavior: Relaxation Training
 Behavior: Behavior therapy
 Behavior: Family Counseling
Phase III

MedlinePlus related topics:  Obsessive-Compulsive Disorder

Study Type: Interventional
Study Design: Treatment, Randomized

Official Title: Behavior Therapy for Childhood OCD

Further Study Details: 

Study start: December 1998;  Study completion: November 2003

To evaluate a standardized multicomponent cognitive behavioral treatment program for child and adolescent obsessive-compulsive disorder (OCD). The treatment program consists of individual Exposure and Response Prevention (ERP) for the OCD child plus a concurrent family intervention designed to reduce OCD-related family conflict, facilitate family disengagement from the affected child's OCD behavior, and rebuild normal family interaction patterns. The ERP/Family Treatment Program is compared with Relaxation Training (RT).

OCD is a chronic, often disabling disorder in childhood that has been associated with increased rates of parental psychopathology and significant disruptions in family relationships and functioning. Preliminary studies suggest that ERP is an effective treatment for children with OCD although no controlled trials to this effect have been published. RT was selected as the comparison treatment because of its credibility as an anxiety treatment and familiarity to potential subjects. RT has been used as a comparison condition for at least 2 randomized controlled ERP trials for adult OCD and shown to be ineffective in treating this disorder. Although it has long been hypothesized that family participation in treatment may be helpful, this is the first controlled study incorporating a systematic manualized family treatment component.

Participants are randomly assigned to receive either the combined ERP/Family Treatment Program (n=56) or RT (n=24). Both treatments are delivered over 12 90-minute outpatient sessions according to detailed treatment manuals.Youth and families undergo comprehensive and systematic, including behavioral, assessments by blind clinical evaluators at baseline, monthly during treatment, post-treatment and 2 follow-up evaluations over 6 months. Treatment outcome is examined in multimodal fashion and across multiple functional domains with a special emphasis on family contextual variables. The impact of baseline functioning, including family context, and initial change over time on treatment outcome is also systematically evaluated.

Eligibility

Ages Eligible for Study:  8 Years   -   17 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

    Patients must have: Obsessive-compulsive disorder for which he/she has not received medication.


    Location Information


    California
          Univ. of California / Los Angeles / Neuropsychiatric Inst., Los Angeles,  California,  90024-1759,  United States

    Study chairs or principal investigators

    John C. Piacentini, PhD,  Principal Investigator

    More Information

    Study ID Numbers:  MH58459
    Record last reviewed:  November 2004
    Last Updated:  November 9, 2004
    Record first received:  November 2, 1999
    ClinicalTrials.gov Identifier:  NCT00000386
    Health Authority: United States: Federal Government
    ClinicalTrials.gov processed this record on 2005-04-08


    Source: ClinicalTrials.gov
    Cache Date: April 8, 2005


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