Similar to other types of hemochromatosis, type 4 causes excess storage of iron in the body's tissues and organs, particularly the liver. Type 4 hemochromatosis is characterized by a dominant inheritance pattern, which means the disorder is found in each generation of a family. Hemochromatosis, type 4 is a subtype of hemochromatosis. The signs and symptoms of type 4 hemochromatosis are similar to those of other hemochromatosis disorders and can include joint pain, fatigue, decreased production of sex hormones, and liver disease. A distinguishing feature of type 4 hemochromatosis is the early accumulation of iron in specialized cells called reticuloendothelial cells within the liver, spleen, and bone marrow. Also, compared to individuals with other types of hemochromatosis, people with type 4 have normal or closer-to-normal values for serum transferrin saturation, a blood test which indicates the amount of iron carried in the bloodstream.