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Neurofibromatosis 2 |
BANF; Bilateral Acoustic Neurofibromatosis; Familial Acoustic Neuromas; Schwannoma, Acoustic, Bilateral |
Clinical Trial: NF2 Natural History Consortium
This study is currently recruiting patients.
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Purpose
OBJECTIVES: I. Define the growth rates and clinical course of NF2-related tumors in patients with neurofibromatosis type 2. Associate growth rate with physical function.
| Condition |
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| Schwannoma, Vestibular Neurofibromatosis 2 Meningioma |
MedlinePlus related topics: Acoustic Neuroma; Cancer; Cancer Alternative Therapy; Neurofibromatosis; Neurologic Diseases
Genetics Home Reference related topics: neurofibromatosis 2
Study Type: Observational
Study Design: Natural History, Longitudinal
Expected Total Enrollment: 100
Study start: January 2002
PROTOCOL OUTLINE: Data on the clinical course and growth rate of NF2-related tumors in patients with neurofibromatosis 2. Patients are evaluated each year on a cranial and a spinal MRI, eye tests, hearing tests, quality of life, neurological tests, and physical functioning.
Eligibility
Ages Eligible for Study: 5 Years and above, Genders Eligible for Study: Both
Criteria
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
- Diagnosed with neurofibromatosis 2 on or after 01/01/93
- Must meet one of the following conditions: Bilateral vestibular schwannoma OR Family history of neurofibromatosis 2 (first degree family relative) AND Unilateral vestibular schwannoma at under 30 years OR Any 2 of the following: Meningioma Glioma Schwannoma Juvenile posterior subcapsular lenticular opacity/juvenile cortical cataract
- No plans to treat vestibular schwannoma in next 12 months
--Prior/Concurrent Therapy--
- Not specified
--Patient Characteristics--
- Age: 5 and over
Location and Contact Information
California
House Ear Institute, Los Angeles, California, 90057-9927, United States; Recruiting
William H. Slattery, III, Study Chair, House Ear Institute
More Information
Publications
Masuda, Ann. Slattery, William H. III, Fisher, Laurel M., Oppenheimer, Mark. Audiological Characteristics of Initial Presentation of NF2 Patients: Preliminary Results. Abstract submitted to: Combined Otolaryngological Spring Meetings (COSM).
Fisher, Laurel M., Slattery, WIlliam H. III, Yoon, Gloria. MRI Test-Retest Study of NF2 Patients. Abstract Submitted to: Combined Otolaryngological Spring Meetings (COSM).
Masuda A, Fisher LM, Oppenheimer ML, Iqbal Z, Slattery WH; Natural History Consortium. Hearing changes after diagnosis in neurofibromatosis type 2. Otol Neurotol. 2004 Mar;25(2):150-4.
Record last reviewed: January 2005
Last Updated: January 21, 2005
Record first received: October 18, 1999
ClinicalTrials.gov Identifier: NCT00004483
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- Neurofibromatosis 2 (Genetics Home Reference)
- Neurofibromatosis 2 (Google Health)
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