The purpose of this study is to examine the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in treating vascular depression.

Vascular depression is a condition that typically affects the elderly and is associated with small vascular lesions. It is more resistant to treatment and has a poorer outcome than nonvascular depression. By altering excitability in the cortical area of the brain, rTMS may be an effective treatment neuropsychiatric conditions, particularly depression.

Participants in this study will be randomly assigned to 15 treatments of either rTMS or sham rTMS for 3 weeks. Following treatment, participants will receive citalopram for 9 weeks. Response rates to treatment; relapse rates; the size, number, and location of the vascular lesions; and the amount of regional brain atrophy will be measured. Improvements in activities of daily living, quality of life, and cognitive function will also be also measured.

Ages Eligible for Study:  51 Years   -   89 Years,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• DSM-IV diagnosis of unipolar major or minor depressive disorder
• Hamilton Depression Rating Scale score of at least 18
• Depression that is associated with cerebrovascular disease
• Failed at least 1 treatment for vascular depression