Complementary medicine Clinical Trials

• Effectiveness of an Internet-Based Curriculum in Increasing Health Care Providers' Knowledge of Herbs and Dietary Supplements
  ClinicalTrials.gov Identifier: NCT00110539 - Active, not recruiting
  
  
• Complementary and Alternative Medicine Use in Low-Income African American and Caucasian Adults With Asthma
  ClinicalTrials.gov Identifier: NCT00094419 - Recruiting
  Asthma
  
• Complementary or Alternative Medicine Practices Used by Women at Increased Risk for Breast Cancer
  ClinicalTrials.gov Identifier: NCT00020098 - Active, not recruiting
  prevention of breast cancer
  
• Complementary and Alternative Medicine for Urological Symptoms
  ClinicalTrials.gov Identifier: NCT00097136 - Recruiting
  Prostatic Hyperplasia
  
• Complementary Treatment of PG2 to Improve Clinical Benefit Response and Quality of Life in Fatigue
  ClinicalTrials.gov Identifier: NCT00518869 - Recruiting
  Quality of Life; Fatigue; Complementary
  
• Huang Lian (Chinese Herb) in Treating Patients With Advanced Solid Tumors
  ClinicalTrials.gov Identifier: NCT00014378 - Active, not recruiting
  unspecified adult solid tumor, protocol specific
  
• Pomegranate Juice in Treating Patients With Recurrent Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00060086 - Active, not recruiting
  adenocarcinoma of the prostate; recurrent prostate cancer
  
• Silymarin (Milk Thistle Extract) in Treating Patients With Acute Lymphoblastic Leukemia Who Are Receiving Chemotherapy
  ClinicalTrials.gov Identifier: NCT00055718 - Active, not recruiting
  Drug Toxicity; childhood acute lymphoblastic leukemia
  
• Herbal Therapy in Treating Women With Metastatic Breast Cancer
  ClinicalTrials.gov Identifier: NCT00028977 - Active, not recruiting
  stage IV breast cancer; recurrent breast cancer
  
• American Ginseng in Treating Patients With Cancer-Related Fatigue
  ClinicalTrials.gov Identifier: NCT00182780 - Active, not recruiting
  Fatigue; unspecified adult solid tumor, protocol specific
  
• Mistletoe in Treating Patients With Advanced Non-Small Cell Lung Cancer Who Are Receiving Palliative Chemotherapy
  ClinicalTrials.gov Identifier: NCT00052325 - Active, not recruiting
  stage IV non-small cell lung cancer; stage IIIB non-small cell lung cancer
  
• Erlotinib and Green Tea Extract (Polyphenon® E) in Preventing Cancer Recurrence in Former Smokers Who Have Undergone Surgery for Bladder Cancer
  ClinicalTrials.gov Identifier: NCT00088946 - Active, not recruiting
  transitional cell carcinoma of the bladder; stage 0 bladder cancer; stage I bladder cancer
  
• Valeriana Officinalis (Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy
  ClinicalTrials.gov Identifier: NCT00075842 - Active, not recruiting
  Sleep Disorders; unspecified adult solid tumor, protocol specific; Fatigue
  
• Green Tea Extract in Preventing Esophageal Cancer in Patients With Barrett''s Esophagus
  ClinicalTrials.gov Identifier: NCT00233935 - Recruiting
  Esophageal Cancer; Precancerous Condition
  
• The Association Between the Use of Complementary and Alternative Medicine and Medication Adherence in Hypertensive African-Americans
  ClinicalTrials.gov Identifier: NCT00227201 - Completed
  Hypertension
  
• Complementary Testing to Evaluate Immunogenicity of HPV Vaccine (580299) in Healthy Female Subjects Aged >/= 26 Years
  ClinicalTrials.gov Identifier: NCT00456807 - Active, not recruiting
  HPV-16/18 Infections; Cervical Neoplasia
  
• Study of Complementary Therapies in Men Receiving Radiation Therapy for Prostate Cancer: A Feasibility Trial
  ClinicalTrials.gov Identifier: NCT00207259 - Active, not recruiting
  Prostate Cancer
  
• Effect of Complementary Intracoronary Streptokinase Administrated Just After Primary Percutaneous Coronary Intervention on Microvascular Perfusion in Patients With Acute Myocardial Infarction
  ClinicalTrials.gov Identifier: NCT00302419 - Active, not recruiting
  Acute Myocardial Infarction
  
• Complementary Intradialytic Nutritional Supplementation in Dialysis Patients
  ClinicalTrials.gov Identifier: NCT00179205 - Recruiting
  End Stage Renal Disease
  
• The Effect of a Complementary Multi Disciplinary Program on Blood Pressure in Hypertensive Patients
  ClinicalTrials.gov Identifier: NCT00409149 - Recruiting
  Hypertension
  
• Modification in Complementary Food Composition to Improve the Status of Iron and Fatty Acids in Infants.
  ClinicalTrials.gov Identifier: NCT00571948 - Active, not recruiting
  Iron Status; Fatty Acid Status
  
• Hypericum Perforatum (St. John's wort) in Relieving Hot Flashes in Women With Non-Metastatic Breast Cancer
  ClinicalTrials.gov Identifier: NCT00110136 - Recruiting
  Breast Cancer; breast cancer in situ; Hot Flashes
  
• Ginger in Treating Nausea in Patients Receiving Chemotherapy for Cancer
  ClinicalTrials.gov Identifier: NCT00040742 - Recruiting
  nausea and vomiting; unspecified adult solid tumor, protocol specific
  
• Socioeconomic Influences on Complementary and Alternative Medicine Use in Cancer Treatment
  ClinicalTrials.gov Identifier: NCT00087932 - Completed
  Neoplasms
  
• Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease
  ClinicalTrials.gov Identifier: NCT00031720 - Recruiting
  Breast Cancer; breast cancer in situ; Hot Flashes
  
• Adolescents' Use of Complementary and Alternative Medicine
  ClinicalTrials.gov Identifier: NCT00032656 - Completed
  Healthy
  
• Fruit and Vegetable Extracts in Treating Patients With Stage I, Stage II, Stage III, Stage IVA, or Stage IVB Head and Neck Cancer
  ClinicalTrials.gov Identifier: NCT00064298 - Recruiting
  Hypopharyngeal Cancer; Laryngeal Cancer; lip and oral cavity cancer; Oropharyngeal Cancer
  
• Selenium and Vitamin E in Preventing Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00006392 - Active, not recruiting
  Prostate Cancer
  
• Soy Protein Supplement in Preventing Prostate Cancer in Patients With Elevated Prostate-Specific Antigen Levels
  ClinicalTrials.gov Identifier: NCT00031746 - Active, not recruiting
  Prostate Cancer
  
• Complementary Naturopathic Medicine for Periodontitis
  ClinicalTrials.gov Identifier: NCT00010634 - Completed
  Periodontitis
  
• Antineoplaston Therapy in Treating Patients With Glioblastoma Multiforme
  ClinicalTrials.gov Identifier: NCT00003456 - Active, not recruiting
  adult glioblastoma
  
• Mistletoe Lectin in Treating Patients With Refractory Advanced Solid Tumors
  ClinicalTrials.gov Identifier: NCT00006477 - Active, not recruiting
  unspecified adult solid tumor, protocol specific
  
• Omega-3 Fatty Acids in Preventing Breast Cancer in Women at High Risk of Developing Breast Cancer
  ClinicalTrials.gov Identifier: NCT00114296 - Active, not recruiting
  Breast Cancer
  
• Mistletoe Lectin in Treating Patients With Advanced Solid Tumors That Have Not Responded to Previous Therapy
  ClinicalTrials.gov Identifier: NCT00006354 - Active, not recruiting
  unspecified adult solid tumor, protocol specific
  
• Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation
  ClinicalTrials.gov Identifier: NCT00080873 - Active, not recruiting
  Cancer; oral complications of cancer and cancer therapy
  
• Complementary Hyperbaric Oxygen for Brain Tissue Damage Caused by Radiation Therapy
  ClinicalTrials.gov Identifier: NCT00087815 - Active, not recruiting
  Abnormalities, Radiation Induced
  
• Irinotecan and Selenium in Treating Patients With Advanced Solid Tumors
  ClinicalTrials.gov Identifier: NCT00112892 - Active, not recruiting
  unspecified adult solid tumor, protocol specific
  
• Lycopene in Treating Patients With Metastatic Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00068731 - Active, not recruiting
  stage IV prostate cancer; recurrent prostate cancer
  
• Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer
  ClinicalTrials.gov Identifier: NCT00053053 - Active, not recruiting
  adult solid tumor; Cachexia; Lymphoma
  
• Antineoplaston Therapy in Treating Patients With Advanced Head and Neck Cancer
  ClinicalTrials.gov Identifier: NCT00003489 - Active, not recruiting
  Head and Neck Cancer
  
• Folate-Depleted Diet Compared With Folate-Supplemented Diet in Preventing Colorectal Cancer in Patients at High Risk for Colorectal Cancer
  ClinicalTrials.gov Identifier: NCT00096330 - Active, not recruiting
  Colon Cancer; Rectal Cancer
  
• Levocarnitine in Treating Fatigue in Cancer Patients
  ClinicalTrials.gov Identifier: NCT00091169 - Active, not recruiting
  Fatigue; unspecified adult solid tumor, protocol specific
  
• Antineoplaston Therapy in Treating Patients With Meningioma
  ClinicalTrials.gov Identifier: NCT00003483 - Active, not recruiting
  recurrent adult brain tumor; adult malignant meningioma
  
• Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Waldenstrom's Macroglobulinemia
  ClinicalTrials.gov Identifier: NCT00003512 - Active, not recruiting
  refractory plasma cell neoplasm; Waldenstrom's Macroglobulinemia
  
• Acupuncture as Complementary Therapy for Cerebral Palsy
  ClinicalTrials.gov Identifier: NCT00221247 - Recruiting
  Cerebral Palsy
  
• Antineoplaston Therapy in Treating Patients With Glioblastoma Multiforme
  ClinicalTrials.gov Identifier: NCT00003474 - Active, not recruiting
  recurrent adult brain tumor; adult glioblastoma multiforme
  
• Antineoplaston Therapy in Treating Patients With Cancer of the Small Intestine
  ClinicalTrials.gov Identifier: NCT00003522 - Active, not recruiting
  small intestine adenocarcinoma; recurrent small intestine cancer
  
• Antineoplaston Therapy in Treating Patients With Metastatic or Unresectable Colon Cancer
  ClinicalTrials.gov Identifier: NCT00003485 - Active, not recruiting
  stage IV colon cancer; recurrent colon cancer; adenocarcinoma of the colon
  
• Antineoplaston Therapy in Treating Patients With Metastatic Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00003533 - Active, not recruiting
  adenocarcinoma of the prostate; stage IV prostate cancer; recurrent prostate cancer
  
• Antineoplaston Therapy in Treating Women With Stage IV Breast Cancer
  ClinicalTrials.gov Identifier: NCT00003454 - Active, not recruiting
  stage IV breast cancer; recurrent breast cancer
  
• Behavior-Based Dietary Intervention in Treating Patients With Hormone-Refractory Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00082732 - Active, not recruiting
  stage I prostate cancer; stage II prostate cancer; adenocarcinoma of the prostate
  
• Mistletoe as Complementary Treatment in Patients With Advanced Non-Small-Cell Lung Cancer (NSCLC), Treated With Carboplatin/Gemcitabine Chemotherapy Combination: Randomized Phase II Study
  ClinicalTrials.gov Identifier: NCT00516022 - Recruiting
  Non Small Cell Lung Cancer
  
• Antineoplaston Therapy in Treating Patients With Metastatic, Recurrent, or Refractory Neuroblastoma
  ClinicalTrials.gov Identifier: NCT00003513 - Active, not recruiting
  regional neuroblastoma; disseminated neuroblastoma; stage 4S neuroblastoma; recurrent neuroblastoma; localized unresectable neuroblastoma
  
• Antineoplaston Therapy in Treating Patients With Refractory Stage IV Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00003534 - Active, not recruiting
  adenocarcinoma of the prostate; stage IV prostate cancer; recurrent prostate cancer
  
• Oregon Center for Complementary and Alternative Medicine in Neurological Disorders
  ClinicalTrials.gov Identifier: NCT00010881 - Completed
  Neurological Disorders
  
• Soy Isoflavones in Treating Patients Who Are Undergoing Radical Prostatectomy for Stage I or Stage II Adenocarcinoma of the Prostate
  ClinicalTrials.gov Identifier: NCT00078923 - Active, not recruiting
  stage I prostate cancer; stage II prostate cancer; adenocarcinoma of the prostate
  
• Omeprazole and Amoxicillin and/or Vitamin and Mineral Supplements and/or Garlic Supplements in Preventing Stomach Cancer in Patients With Precancerous Stomach Lesions
  ClinicalTrials.gov Identifier: NCT00134121 - Active, not recruiting
  Gastric Cancer; Precancerous Condition
  
• Shark Cartilage Extract in Treating Patients With Metastatic Kidney Cancer
  ClinicalTrials.gov Identifier: NCT00005995 - Active, not recruiting
  Stage IV Renal Cell Cancer; Renal Cell Adenocarcinoma; recurrent renal cell cancer
  
• Antineoplaston Therapy in Treating Patients With Ependymoma
  ClinicalTrials.gov Identifier: NCT00003479 - Active, not recruiting
  adult ependymoma; newly diagnosed childhood ependymoma; recurrent childhood ependymoma; adult anaplastic ependymoma
  
• Antineoplaston Therapy in Treating Patients With Recurrent or Refractory High-Grade Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma
  ClinicalTrials.gov Identifier: NCT00003501 - Active, not recruiting
  adult Burkitt's lymphoma; adult immunoblastic large cell lymphoma; adult lymphoblastic lymphoma
  
• Clinical Integration of Genetic Risk Assessment in Family Medicine
  ClinicalTrials.gov Identifier: NCT00339794 - Active, not recruiting
  Genomics
  
• Diet and PSA Levels in Patients With Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00003367 - Active, not recruiting
  stage II prostate cancer; stage III prostate cancer; stage IV prostate cancer; stage I prostate cancer; adenocarcinoma of the prostate; ...
  
• Antineoplaston Therapy in Treating Patients With Stomach Cancer
  ClinicalTrials.gov Identifier: NCT00003524 - Active, not recruiting
  stage III gastric cancer; stage IV gastric cancer; recurrent gastric cancer; adenocarcinoma of the stomach
  
• Antineoplaston Therapy in Treating Patients With Low-Grade Astrocytoma
  ClinicalTrials.gov Identifier: NCT00003471 - Active, not recruiting
  recurrent adult brain tumor; adult well-differentiated mildly and moderately anaplastic astrocytoma; adult juvenile pilocytic astrocytoma; ...
  
• Use of Herbal Medicine in Internal Medicine Wards
  ClinicalTrials.gov Identifier: NCT00564473 - Not yet recruiting
  Herb-Drug Interactions
  
• Complementary Medicine Approaches to TMD Pain Management
  ClinicalTrials.gov Identifier: NCT00010621 - Completed
  Temporomandibular Joint Disorders
  
• Sho-Saiko-To Following Removal of Liver Cancer By Embolization in Treating Patients With Liver Cancer That Cannot Be Surgically Removed
  ClinicalTrials.gov Identifier: NCT00040898 - Active, not recruiting
  localized unresectable adult primary liver cancer; advanced adult primary liver cancer; recurrent adult primary liver cancer; ...
  
• Antineoplaston Therapy in Treating Patients With Stage IV Cancer of the Cervix and/or Vulva
  ClinicalTrials.gov Identifier: NCT00003525 - Active, not recruiting
  stage IV cervical cancer; recurrent cervical cancer; stage IV vulvar cancer; recurrent vulvar cancer
  
• Antineoplaston Therapy in Treating Patients With Stage IV Non-small Cell Lung Cancer
  ClinicalTrials.gov Identifier: NCT00003497 - Active, not recruiting
  recurrent non-small cell lung cancer; stage IV non-small cell lung cancer
  
• Exploring Integrative Medicine in Swedish Primary Care
  ClinicalTrials.gov Identifier: NCT00565942 - Active, not recruiting
  Back or Neck Pain of at Least 2 Weeks Duration
  
• Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Prostate Cancer
  ClinicalTrials.gov Identifier: NCT00003516 - Active, not recruiting
  adenocarcinoma of the prostate; stage III prostate cancer; stage IV prostate cancer; recurrent prostate cancer
  
• Antineoplaston Therapy in Treating Patients With Stage IV Lung Cancer
  ClinicalTrials.gov Identifier: NCT00003491 - Active, not recruiting
  recurrent non-small cell lung cancer; stage IV non-small cell lung cancer; Adenocarcinoma of the Lung
  
• Antineoplaston Therapy in Treating Patients With Recurrent or Extensive-Stage Small Cell Lung Cancer
  ClinicalTrials.gov Identifier: NCT00003496 - Active, not recruiting
  extensive stage small cell lung cancer; Recurrent Small Cell Lung Cancer
  
• Gemcitabine Compared With Pancreatic Enzyme Therapy Plus Specialized Diet (Gonzalez Regimen) in Treating Patients Who Have Stage II, Stage III, or Stage IV Pancreatic Cancer
  ClinicalTrials.gov Identifier: NCT00003851 - Active, not recruiting
  stage II pancreatic cancer; stage III pancreatic cancer; stage IV pancreatic cancer; Nutrition; adenocarcinoma of the pancreas
  
• Antineoplaston Therapy in Treating Patients With Recurrent or Stage IV Lung Cancer
  ClinicalTrials.gov Identifier: NCT00003494 - Active, not recruiting
  recurrent non-small cell lung cancer; stage IV non-small cell lung cancer; Bronchoalveolar Cell Lung Cancer
  
• Antineoplaston Therapy in Treating Patients With Recurrent or Stage IV Lung Cancer
  ClinicalTrials.gov Identifier: NCT00003495 - Active, not recruiting
  recurrent non-small cell lung cancer; Squamous Cell Lung Cancer; stage IV non-small cell lung cancer
  
• Antineoplaston Therapy in Treating Patients With Metastatic, Recurrent, or Refractory Primitive Neuroectodermal Tumors
  ClinicalTrials.gov Identifier: NCT00003515 - Active, not recruiting
  metastatic childhood soft tissue sarcoma; recurrent childhood soft tissue sarcoma; metastatic tumors of the Ewing's family; ...
  
• Antineoplaston Therapy in Treating Patients With Stage IV Kidney Cancer
  ClinicalTrials.gov Identifier: NCT00003520 - Active, not recruiting
  Stage IV Renal Cell Cancer; recurrent renal cell cancer; Renal Cell Adenocarcinoma; ...
  
• Antineoplaston Therapy in Treating Patients With Brain Stem Glioma
  ClinicalTrials.gov Identifier: NCT00003459 - Active, not recruiting
  recurrent adult brain tumor; adult brain stem glioma; untreated childhood brain stem glioma; recurrent childhood brain stem glioma
  
• Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System
  ClinicalTrials.gov Identifier: NCT00032383 - Completed
  Vestibular Neuronitis; Vestibulopathy
  
• Antineoplaston Therapy in Treating Patients With Primary Liver Cancer
  ClinicalTrials.gov Identifier: NCT00003530 - Active, not recruiting
  stage IV childhood liver cancer; recurrent childhood liver cancer; advanced adult primary liver cancer; recurrent adult primary liver cancer
  
• Antineoplaston Therapy in Treating Patients With Refractory or Recurrent Intermediate-Grade Stage II, Stage III, or Stage IV Non-Hodgkin's Lymphoma
  ClinicalTrials.gov Identifier: NCT00003500 - Active, not recruiting
  adult diffuse large cell lymphoma; adult diffuse mixed cell lymphoma; adult diffuse small cleaved cell lymphoma; grade 3 follicular lymphoma
  
• Calcitriol in Preventing Prostate Cancer in Patients with Prostatic Intraepithelial Neoplasia
  ClinicalTrials.gov Identifier: NCT00118066 - Recruiting
  Prostate Cancer; Precancerous Condition
  
• Antineoplaston Therapy in Treating Patients With Soft Tissue Sarcoma
  ClinicalTrials.gov Identifier: NCT00003521 - Active, not recruiting
  stage III adult soft tissue sarcoma; stage IV adult soft tissue sarcoma; recurrent adult soft tissue sarcoma; ...
  
• Antineoplaston Therapy in Treating Children With Brain Tumors
  ClinicalTrials.gov Identifier: NCT00003458 - Recruiting
  childhood brain tumor
  
• Coenzyme Q10 in Relieving Treatment-Related Fatigue in Women With Breast Cancer
  ClinicalTrials.gov Identifier: NCT00096356 - Recruiting
  Breast Cancer; Fatigue
  
• Antineoplaston Therapy in Treating Patients With Primary Malignant Brain Tumors
  ClinicalTrials.gov Identifier: NCT00003475 - Recruiting
  adult brain tumor
  
• Antineoplaston Therapy in Treating Patients With Non-Hodgkin's Lymphoma
  ClinicalTrials.gov Identifier: NCT00003498 - Recruiting
  adult non-Hodgkin's lymphoma
  
• Antineoplaston Therapy in Treating Children With Primary Malignant Brain Tumors
  ClinicalTrials.gov Identifier: NCT00003476 - Recruiting
  childhood brain tumor; childhood meningioma
  
• Antineoplaston Therapy in Treating Patients With Stage III or Stage IV Ovarian Cancer
  ClinicalTrials.gov Identifier: NCT00003532 - Active, not recruiting
  stage III ovarian epithelial cancer; stage IV ovarian epithelial cancer; recurrent ovarian epithelial cancer; stage III ovarian germ cell tumor; ...
  
• Antineoplaston Therapy in Treating Patients With Stage IV Melanoma
  ClinicalTrials.gov Identifier: NCT00003509 - Recruiting
  Stage IV Melanoma; Recurrent Melanoma
  
• Antineoplaston Therapy in Treating Patients With Advanced Mesothelioma
  ClinicalTrials.gov Identifier: NCT00003508 - Recruiting
  advanced malignant mesothelioma; recurrent malignant mesothelioma
  
• Transfusion Medicine - Prevention of Bedside Errors
  ClinicalTrials.gov Identifier: NCT00127556 - Active, not recruiting
  Blood transfusion
  
• IH636 Grape Seed Extract in Preventing Breast Cancer in Postmenopausal Women at Risk of Developing Breast Cancer
  ClinicalTrials.gov Identifier: NCT00100893 - Recruiting
  Breast Cancer
  
• Antineoplaston Therapy in Treating Patients With Recurrent or Refractory Mixed Gliomas
  ClinicalTrials.gov Identifier: NCT00003473 - Recruiting
  recurrent adult brain tumor; Mixed Gliomas
  
• Antineoplaston Therapy in Treating Women With Advanced Breast Cancer
  ClinicalTrials.gov Identifier: NCT00003455 - Recruiting
  stage IV breast cancer; recurrent breast cancer
  
• Antineoplaston Therapy in Treating Patients With Primary Central Nervous System Lymphoma
  ClinicalTrials.gov Identifier: NCT00003505 - Recruiting
  primary central nervous system lymphoma
  
• Antineoplaston Therapy in Treating Patients With Anaplastic Astrocytoma
  ClinicalTrials.gov Identifier: NCT00003470 - Recruiting
  recurrent adult brain tumor; adult anaplastic astrocytoma
  
• Methotrexate With or Without Antineoplaston Therapy in Treating Postmenopausal Women With Advanced Refractory Breast Cancer
  ClinicalTrials.gov Identifier: NCT00003536 - Recruiting
  stage IV breast cancer; recurrent breast cancer
  
• Antineoplaston Therapy in Treating Patients With Cancer of Unknown Primary Origin
  ClinicalTrials.gov Identifier: NCT00003526 - Recruiting
  adenocarcinoma of unknown primary; recurrent carcinoma of unknown primary