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Electrophysiologic Measures of Treatment Response in Alzheimer Disease - Article


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Clinical Trial: Electrophysiologic Measures of Treatment Response in Alzheimer Disease

This study has been completed.

Sponsored by: Department of Veterans Affairs
Information provided by: Department of Veterans Affairs

Purpose

The main purpose of this study is to determine the electrophysiological effects of cholinergic therapy (cholinesterase inhibitors and transdermal nicotine) in Alzheimer disease. The attempt will be to locate electrophysiological markers and predictors of cognitive and clinical treatment response.

Condition Treatment or Intervention Phase
Alzheimer Disease
 Drug: Aricept
 Drug: Exelon
 Drug: Nicoderm Patch
Phase IV

MedlinePlus related topics:  Alzheimer's Caregivers;   Alzheimer's Disease
Genetics Home Reference related topics:  Alzheimer disease

Study Type: Interventional
Study Design: Treatment, Non-Randomized, Open Label, Uncontrolled, Crossover Assignment, Efficacy Study

Official Title: Verbal Memory ERPs as Indices of Treatment Response in Alzheimer Disease

Further Study Details: 

Study start: October 1998;  Study completion: September 2001

Eligibility

Ages Eligible for Study:  55 Years   -   85 Years,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Patients diagnosed with mild to moderate probable Alzheimer's disease (mini-mental state exam scores between 15-27), and normal controls (age generally between 60-85). Subjects must either be planning to start daily cholinesterase therapy (e.g. Aricept, Exelon) or willing to try a transdermal nicotine patch for two 8 hour periods.

Location Information


California
      Department of Veterans Affairs, San Diego,  California,  92161,  United States

Study chairs or principal investigators

Vincente Iragui, M.D., Ph.D
Shuanna Morris, Ph.D.

More Information

Study ID Numbers:  AGCG-004-98S
Record last reviewed:  December 2004
Last Updated:  December 30, 2004
Record first received:  July 3, 2001
ClinicalTrials.gov Identifier:  NCT00018278
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08


Source: ClinicalTrials.gov
Cache Date: April 9, 2005

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Page Updated: September 6, 2005
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