Not Signed In -
S-adenosyl methionine (SAM-e) |
Ademetionine; S-adenosyl-L-methionine; S-Adenosylmethionine; SAM; SAMe; Sammy |
Clinical Trial: Study of Phosphatidylcholine in a Patient With Methionine Adenosyltransferase Deficiency
This study has been completed.
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Purpose
OBJECTIVES: I. Determine whether plasma choline and breast milk choline levels are low at fasting in a patient with methionine adenosyltransferase deficiency, and if the choline levels are low, determine whether choline levels respond to dietary supplementation with phosphatidylcholine. II. Determine whether this patient has a fatty liver by magnetic resonance spectroscopy.
| Condition | Treatment or Intervention |
|---|---|
| Methionine Adenosyltransferase Deficiency Metabolism, Inborn Errors | Drug: phosphatidylcholine |
MedlinePlus related topics: Birth Defects; Genetic Disorders; Metabolic Disorders
Study Type: Interventional
Study Design: Treatment
Expected Total Enrollment: 1
Study start: January 2000; Study completion: January 2000
PROTOCOL OUTLINE: Blood is drawn for liver function tests and measurement of plasma choline levels and breast milk samples are taken for measurement of breast milk choline levels at fasting and at 1 hour after breakfast on day 1. The patient then undergoes magnetic resonance spectroscopy of the liver to assess liver density and choline compound mass. The patient then receives oral phosphatidylcholine supplement, and plasma and breast milk samples are taken at 3 and 6 hours after the dose. Oral phosphatidylcholine supplements continue for 30 days. The above studies are repeated on day 31.
Eligibility
Ages Eligible for Study: 20 Years - 20 Years, Genders Eligible for Study: Female
Criteria
- Patient with methionine adenosyltransferase deficiency who is nursing
Location Information
Steven H. Zeisel, Study Chair, UNC Lineberger Comprehensive Cancer Center
More Information
Record last reviewed: July 2000
Last Updated: October 13, 2004
Record first received: July 5, 2000
ClinicalTrials.gov Identifier: NCT00006061
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 9, 2005
Resources
- ademetionine (University of Maryland Medical Center)
- Ademetionine (Drug Digest)
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