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Topiramate |
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Topiramate Systematic (IUPAC) name 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate Identifiers CAS number 97240-79-4 ATC code N03AX11 PubChem 5284627 DrugBank APRD00237 Chemical data Formula C12H21NO8S Mol. weight 339.363 g/mol SMILES NS(=O)(=O)OC[C@@]13OC(C)(C)O[C@H]3C2OC(C)(C)OC2CO1 Pharmacokinetic data Bioavailability 80% Metabolism 30% hepatic, 70% is excreted unchanged Half life 19 to 23 hours Excretion 70% renal (in urine) in un ...
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Topiramate Clinical Trials
- Relationship Between Topiramate Use and Ocular Angle Status
ClinicalTrials.gov Identifier: NCT00153699 - Active, not recruiting
Glaucoma, Angle-Closure
- Topiramate as Adjunctive Therapy in Infants 1-23 Months for the Control of Partial Onset Seizures
ClinicalTrials.gov Identifier: NCT00113815 - Active, not recruiting
Partial Seizure Disorder; Epilepsy; Seizures
- Evaluation of the Effectiveness of Topiramate in Preventing the Transformation from Episodic Migraine to Chronic Daily Headache.
ClinicalTrials.gov Identifier: NCT00212810 - Active, not recruiting
Classic Migraine; Common Migraine; Migraine; Headache
- A Study to Evaluate the Dosing, Effectiveness and Safety of Topiramate for the Treatment of Epilepsy
ClinicalTrials.gov Identifier: NCT00266604 - Active, not recruiting
Epilepsy, Generalized; Epilepsies, Partial; Seizures, Tonic-Clonic; Seizures; Epilepsy
- Pharmacokinetic Comparison of Multiple Formulations of Topiramate and Phentermine in Obese Adults
ClinicalTrials.gov Identifier: NCT00518466 - Active, not recruiting
Obesity
- A Study on Efficacy and Safety of Topiramate in Treatment of Obese Subjects With Dyslipidemia
ClinicalTrials.gov Identifier: NCT00231621 - Active, not recruiting
Hypertriglyceridemia; Obesity; Hyperlipidemia
- Study of Topiramate Administered as Liquid or Sprinkles in Infants (Aged 1-23 Months) With Refractory POS
ClinicalTrials.gov Identifier: NCT00233012 - Active, not recruiting
Seizures
- An Open Label Extension of a Study of Topiramate in Chronic Migraine.
ClinicalTrials.gov Identifier: NCT00210873 - Active, not recruiting
Migraine
- An Observational Study Evaluating the Safety of Topiramate for the Prevention of Migraine
ClinicalTrials.gov Identifier: NCT00297336 - Active, not recruiting
Migraine
- A Study of the Safety of Topiramate in Adults and Children With Epilepsy
ClinicalTrials.gov Identifier: NCT00297323 - Active, not recruiting
Epilepsy; Seizures
- The Effects of Topiramate on Alcohol Use and Brain Gaba Concentrations in Alcohol Dependent Subjects
ClinicalTrials.gov Identifier: NCT00329407 - Active, not recruiting
Alcoholism
- The Prolonged Use of Topiramate for Preventing Migraine Headaches
ClinicalTrials.gov Identifier: NCT00216619 - Active, not recruiting
Migraine
- Patient, Provider, and Healthcare System Factors Associated with in Suboptimal Prescribing for Older Patients with Epilepsy
ClinicalTrials.gov Identifier: NCT00144001 - Active, not recruiting
Epilepsy
- A Study Using DNA Samples From Patients Who Participated in Previous Topiramate Obesity and Type 2 Diabetes Studies
ClinicalTrials.gov Identifier: NCT00304603 - Active, not recruiting
Diabetes Mellitus, Type 2; Obesity
- A Study of the Efficacy and Safety of Topiramate in the Treatment of Obese, Type 2 Diabetic Patients Treated With Metformin
ClinicalTrials.gov Identifier: NCT00231660 - Active, not recruiting
Diabetes Mellitus, Type 2; Obesity; Diabetes Mellitus, Adult-Onset
- A Study of the Efficacy and Safety of Topiramate in Obese, Type 2 Diabetic Patients Inadequately Controlled on Sulfonylurea Therapy
ClinicalTrials.gov Identifier: NCT00231634 - Active, not recruiting
Diabetes Mellitus, Adult-Onset; Diabetes Mellitus, Type 2; Obesity
- Topiramate in the Treatment of Pathological Gambling
ClinicalTrials.gov Identifier: NCT00245583 - Active, not recruiting
Pathological Gambling
- Effectiveness of Topiramate in Treating Cocaine Dependent Individuals - 1
ClinicalTrials.gov Identifier: NCT00249691 - Recruiting
Cocaine-Related Disorders
- Topiramate for the Prophylactic Treatment of Cyclic Vomiting Syndrome in Children
ClinicalTrials.gov Identifier: NCT00286988 - Recruiting
Vomiting
- A Study of the Safety and Efficacy of Topiramate in the Treatment of Patients with Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00035230 - Completed
Bipolar Disorder
- A Study of the Safety and Efficacy of Topiramate in the Treatment of Patients with Bipolar I Disorder
ClinicalTrials.gov Identifier: NCT00037674 - Completed
Bipolar Disorder
- An Open-Label Study of Topiramate in Pediatric Subjects with Basilar/Hemiplegic Migraine
ClinicalTrials.gov Identifier: NCT00158002 - Completed
Basilar Migraine
- An Open-Label Study to Determine the Efficacy and Safety of Topiramate in the Treatment of Tourette Syndrome.
ClinicalTrials.gov Identifier: NCT00206336 - Recruiting
Tourette Syndrome
- Topiramate in the Treatment of Sciatica
ClinicalTrials.gov Identifier: NCT00011804 - Completed
Sciatica
- Dose Comparison Study of Topiramate in Pediatric Subjects with Basilar/Hemiplegic Migraine
ClinicalTrials.gov Identifier: NCT00131443 - Completed
Basilar Migraine
- Efficacy Study of Quetiapine Plus Topiramate for Reducing Cannabis Consumption and Bipolar Mania
ClinicalTrials.gov Identifier: NCT00393978 - Recruiting
Bipolar Disorder; Cannabis-Related Disorder
- Efficacy of Adding Topiramate to Current Treatment in Treatment-Resistant Generalized Social Phobia (GSP)
ClinicalTrials.gov Identifier: NCT00182455 - Recruiting
Social Phobia
- Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD)
ClinicalTrials.gov Identifier: NCT00182520 - Recruiting
Obsessive Compulsive Disorder
- Topiramate for Alcohol and Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00167245 - Recruiting
Alcoholism; Cocaine Dependence
- Topiramate for the Treatment of Alcohol Dependent Binge-Eating Disordered Individuals
ClinicalTrials.gov Identifier: NCT00300742 - Recruiting
Alcohol Dependence; Binge Eating
- Free Treatment for Cocaine Dependence: A Placebo-Controlled Study of Mixed Amphetamine Salts (Adderall-XR) and Topiramate for the Treatment of Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00421603 - Recruiting
Cocaine Dependence
- Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
ClinicalTrials.gov Identifier: NCT00286923 - Not yet recruiting
Migraine; Chronic Headache
- Pilot Study of Topiramate and Olanzapine in the Prevention of Weight Gain in Children and Adolescents With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00394095 - Recruiting
Bipolar Disorder; Weight Gain
- Medication Development for Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00223626 - Recruiting
Cocaine Dependence
- Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00572117 - Recruiting
Bipolar Disorder; Manic Disorder; Manic-Depressive; Alcoholism; Alcohol Abuse
- Topiramate Augmentation in the Treatment of Obsessive-Compulsive Disorder
ClinicalTrials.gov Identifier: NCT00211744 - Recruiting
Obsessive-Compulsive Disorder
- A Multicenter Comparative Trial of Zonisamide and Topiramate as Initial Monotherapy in Untreated Epilepsies
ClinicalTrials.gov Identifier: NCT00154076 - Recruiting
Pending - We have submitted to each center''s IRB and waiting for results to Epilepsy.
- Efficacy and Tolerability of Topiramate for the Treatment of Bipolar Mania and Alcohol Use in Adolescents
ClinicalTrials.gov Identifier: NCT00550394 - Not yet recruiting
Bipolar Disorder; Alcohol Use
- Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramate for Lennox-Gastaut Syndrome
ClinicalTrials.gov Identifier: NCT00004776 - Completed
Lennox-Gastaut Syndrome
- Topiramate for Treatment of Patients With Borderline Personality Disorder and Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00463775 - Recruiting
Alcohol Dependence; Borderline Personality Disorder
- Treatment of Self-Injurious Behavior in Individuals with Prader-Willi Syndrome
ClinicalTrials.gov Identifier: NCT00065923 - Recruiting
Prader-Willi Syndrome; Self-Injurious Behavior
- An Efficacy and Safety Study of Topiramate in the Treatment of Alcohol Dependence
ClinicalTrials.gov Identifier: NCT00210925 - Completed
Alcoholism
- Antiglutamate Anticonvulsants in the Treatment of Alcohol Withdrawal Syndrome
ClinicalTrials.gov Identifier: NCT00241995 - Completed
Topiramate; Lamotrigine; Memnatine; Diazepam; Placebo
- A study to evaluate the safety and effectiveness of topiramate compared to placebo in the treatment of Bipolar I Disorder.
ClinicalTrials.gov Identifier: NCT00035802 - Terminated
Bipolar Disorder
- A Study of Safety and Efficacy of Topiramate in Male Patients With Abdominal Obesity
ClinicalTrials.gov Identifier: NCT00231608 - Completed
Obesity
- A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine
ClinicalTrials.gov Identifier: NCT00253175 - Completed
Vascular Headaches; Migraine
- A Study of the Efficacy and Safety of Topiramate Treatment in Patients With Epilepsy
ClinicalTrials.gov Identifier: NCT00266591 - Completed
Epilepsy; Seizures
- Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD)
ClinicalTrials.gov Identifier: NCT00203463 - Completed
PTSD
- A Study on Efficacy and Safety of Topiramate in the Treatment of Patients With Obesity
ClinicalTrials.gov Identifier: NCT00236613 - Completed
Obesity
- A Study on Efficacy and Safety of Topiramate in the Treatment of Patients With Obesity
ClinicalTrials.gov Identifier: NCT00236639 - Completed
Obesity
- An Open Label Extension of a Study Comparing Topiramate and Amitriptyline in Migraine Prevention.
ClinicalTrials.gov Identifier: NCT00210860 - Completed
Migraine
- A Study of the Safety of Topiramate Given in Combination With Other Medications in Adults and Children With Seizures.
ClinicalTrials.gov Identifier: NCT00297349 - Completed
Epilepsy; Seizures
- A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine Attacks in Children
ClinicalTrials.gov Identifier: NCT00210535 - Completed
Vascular Headaches; Migraine
- A Study of the Effectiveness and Safety of Topiramate Versus Placebo for Preventing Chronic Migraine Headaches
ClinicalTrials.gov Identifier: NCT00210912 - Completed
Migraine
- A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause.
ClinicalTrials.gov Identifier: NCT00236496 - Completed
Essential Tremor
- A Study of the Effectiveness and Safety of Topiramate in the Treatment of Children With Epilepsy
ClinicalTrials.gov Identifier: NCT00236743 - Completed
Epilepsy; Seizures; Epilepsies, Partial
- A Study of the Efficacy and Safety of Topiramate in the Treatment of Patients With Epilepsy.
ClinicalTrials.gov Identifier: NCT00236847 - Completed
Seizures; Epilepsies, Partial; Epilepsy
- A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Preventing Migraine Headaches in Children
ClinicalTrials.gov Identifier: NCT00237302 - Completed
Migraine
- The Effectiveness and Safety of Topiramate on Prevention of Chronic Migraine
ClinicalTrials.gov Identifier: NCT00216606 - Completed
Migraine
- A Study of Efficacy and Safety of Topiramate in the Treatment of Obese Patients With Mild to Moderate Essential Hypertension
ClinicalTrials.gov Identifier: NCT00236665 - Completed
Hypertension; Obesity
- A Study of the Effectiveness and Safety of Topiramate Compared With a Standard Therapy in Patients Newly Diagnosed With Epilepsy
ClinicalTrials.gov Identifier: NCT00236717 - Completed
Epilepsy; Seizures
- A Study of the Efficacy and Safety of Topiramate in the Treatment of Patients With Difficult to Control Epilepsy
ClinicalTrials.gov Identifier: NCT00236730 - Completed
Epilepsies, Partial; Seizures; Epilepsy
- A Study of the Efficacy and Safety of Topiramate as an Add-on Therapy in the Treatment of Epilepsy Patients With Lennox-Gastaut Syndrome
ClinicalTrials.gov Identifier: NCT00236756 - Completed
Epilepsy; Seizures
- A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment
ClinicalTrials.gov Identifier: NCT00210782 - Completed
Epilepsy
- A Study of the Effectiveness and Safety of Topiramate Monotherapy in Patients With Recently Diagnosed Partial-Onset Seizure
ClinicalTrials.gov Identifier: NCT00230698 - Completed
Epilepsies, Partial; Seizures; Epilepsy
- An Open-Label Study to Evaluate Topiramate Therapy in Migraine Patients, and Its Effects on Subject Responsiveness to Migraine Treatment With Triptans
ClinicalTrials.gov Identifier: NCT00261469 - Completed
Headache
- Topiramate for the Treatment of Methamphetamine Dependence - 1
ClinicalTrials.gov Identifier: NCT00345371 - Completed
Methamphetamine
- A Study To Evaluate The Effect Of Topiramate On Clinical And Electrophysiological Parameters In Subjects With Diabetic Peripheral Polyneuropathy.
ClinicalTrials.gov Identifier: NCT00231673 - Completed
Diabetes Mellitus, Type 2; Polyneuropathies; Diabetic Neuropathies
- Prospective Pilot Study on Metabolism and Weight Changes in Topiramate-Treated Epilepsy Patients
ClinicalTrials.gov Identifier: NCT00236886 - Completed
Seizures; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized
- A Study of the Efficacy and Safety of Topiramate in Epilepsy Patients With Primary Generalized Tonic-Clonic Seizures
ClinicalTrials.gov Identifier: NCT00236418 - Completed
Seizures; Epilepsy
- Topiramate Versus Placebo as Add-on Treatment in Patients With Bipolar Disorder in the Outpatient Setting
ClinicalTrials.gov Identifier: NCT00237289 - Completed
Bipolar Disorder
- A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine
ClinicalTrials.gov Identifier: NCT00236561 - Completed
Headache; Classic Migraine; Common Migraine; Migraine
- A Study on Efficacy and Safety of Topiramate in Maintaining Weight Loss in Obese Patients Following an Intensive, Non-Pharmacologic Weight Loss Program
ClinicalTrials.gov Identifier: NCT00236600 - Completed
Obesity
- A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine
ClinicalTrials.gov Identifier: NCT00231595 - Completed
Classic Migraine; Migraine; Headache; Common Migraine
- A Study of the Efficacy and Safety of Topiramate in the Prevention of Migraine
ClinicalTrials.gov Identifier: NCT00236509 - Completed
Common Migraine; Headache; Migraine; Classic Migraine
- An Efficacy and Tolerability Study for Topiramate in Obese Patients With Binge Eating Disorder.
ClinicalTrials.gov Identifier: NCT00307619 - Completed
Binge Eating
- Topiramate in the Treatment of Posttraumatic Stress Disorder in Civilians
ClinicalTrials.gov Identifier: NCT00208130 - Completed
Post-Traumatic Stress Disorder
- A Study on Safety and Efficacy of Two Doses of Topiramate as Monotherapy in the Treatment of Newly Diagnosed or Recurrent Epilepsy
ClinicalTrials.gov Identifier: NCT00231556 - Completed
Epilepsies, Partial; Epilepsy, Generalized; Seizures; Epilepsy, Tonic-Clonic; Epilepsy
- Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation
ClinicalTrials.gov Identifier: NCT00280839 - Completed
Smoking Cessation
- A Study of the Effectiveness and Safety of Topiramate in the Treatment of Patients With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00240721 - Completed
Bipolar Disorders; Affective Disorders, Psychotic; Mood Disorders
- A Pilot Study of Topiramate in Childhood Absence Epilepsy
ClinicalTrials.gov Identifier: NCT00210574 - Completed
Epilepsy, Absence
- A Study of the Efficacy and Safety of Topiramate as "Add on" Treatment in Epilepsy Patients With Primary Generalized Tonic-Clonic Seizures
ClinicalTrials.gov Identifier: NCT00236704 - Completed
Epilepsy; Seizures
- A Study of the Efficacy and Safety of Topiramate as Add-on Therapy in the Treatment of Epilepsy Patients With Difficult to Treat, Partial-Onset Seizures.
ClinicalTrials.gov Identifier: NCT00236691 - Completed
Epilepsies, Partial; Seizures; Epilepsy
- A Study of the Efficacy and Safety of Topiramate as Add-on Therapy in the Treatment of Epilepsy Patients With Difficult to Treat, Partial-Onset Seizures
ClinicalTrials.gov Identifier: NCT00236860 - Completed
Epilepsy; Epilepsies, Partial; Seizures
- A Study of the Efficacy and Safety of Topiramate as Add-on Therapy in the Treatment of Epilepsy Patients With Difficult to Treat, Partial-Onset Seizures.
ClinicalTrials.gov Identifier: NCT00236873 - Completed
Epilepsy; Epilepsies, Partial; Seizures
- Study to Determine the Efficacy and Safety of Adjunctive Topiramate in the Treatment of Obsessive-Compulsive Disorder
ClinicalTrials.gov Identifier: NCT00187928 - Completed
Obsessive-Compulsive Disorder
- A Study on Efficacy and Safety of Topiramate OROS® Controlled-Release in Obese, Type 2 Diabetic Subjects Managed With Diet or Metformin
ClinicalTrials.gov Identifier: NCT00231647 - Completed
Diabetes Mellitus, Type 2; Diabetes Mellitus, Adult-Onset; Obesity
- Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches
ClinicalTrials.gov Identifier: NCT00210821 - Completed
Migraine; Headache
- A Study of the Safety and Efficacy of Topiramate in the Treatment of Obese, Type 2 Diabetes Patients on a Controlled Diet
ClinicalTrials.gov Identifier: NCT00231530 - Completed
Diabetes Mellitus, Adult-Onset; Obesity; Diabetes Mellitus, Type 2
- A Study of the Safety and Effectiveness of Topiramate on Insulin Sensitivity in Overweight or Obese Patients With Type 2 Diabetes
ClinicalTrials.gov Identifier: NCT00236626 - Completed
Diabetes Mellitus, Adult-Onset; Obesity; Diabetes Mellitus, Type 2
- Efficacy and Safety Study of Topiramate to Treat Restless Legs Syndrome
ClinicalTrials.gov Identifier: NCT00200941 - Completed
Restless Legs Syndrome
- Safety & Efficacy Study Using Topiramate in Posttraumatic Stress Disorder
ClinicalTrials.gov Identifier: NCT00204386 - Completed
Posttraumatic Stress Disorder
- A Study of the Effectiveness and Safety of Topiramate in the Treatment of Moderate to Severe Binge-Eating Disorder Associated With Obesity
ClinicalTrials.gov Identifier: NCT00210808 - Completed
Binge-Eating Disorder; Obesity
- Study of the Pathogenesis of Rett Syndrome
ClinicalTrials.gov Identifier: NCT00004807 - Completed
Rett Syndrome
- Potential Impact (Benefit) of Preventative Treatment with Topamax on the Effectiveness of Axert in the Acute Treatment of Migraine
ClinicalTrials.gov Identifier: NCT00210496 - Completed
Migraine; Common Migraine; Classic Migraine
- Efficacy of Topiramate for Weight Loss in Subjects With Metabolic Syndrome
ClinicalTrials.gov Identifier: NCT00243984 - Suspended
Metabolic Syndrome X; Diabetes Mellitus, Type 2
- Studies of Dextromethorphan and Topiramate to Treat Oral and Facial Pain
ClinicalTrials.gov Identifier: NCT00001725 - Completed
Facial Neuralgia; Pain; Trigeminal Neuralgia
- A Double-Blind, Placebo-Controlled Study Examining the Use of Topiramate in the Treatment of Cluster Headache
ClinicalTrials.gov Identifier: NCT00203190 - Terminated
Cluster Headache
- Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00296959 - Terminated
Parkinson's Disease
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