Not Signed In -
Thioguanine |
6-TG; TG |
Clinical Trial: Combination Chemotherapy in Treating Children With Progressive Brain Tumors
This study is currently recruiting patients.
Purpose
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
PURPOSE: This randomized phase III trial is studying two different combination chemotherapy regimens and comparing how well they work in treating children with low-grade astrocytomas or other residual tumors of the brain.
| Condition | Treatment or Intervention | Phase |
|---|---|---|
| recurrent childhood brain stem glioma recurrent childhood visual pathway glioma recurrent childhood cerebellar astrocytoma recurrent childhood cerebral astrocytoma | Drug: carboplatin Drug: lomustine Drug: procarbazine Drug: thioguanine Drug: vincristine Procedure: chemotherapy | Phase III |
MedlinePlus related topics: Cancer; Cancer Alternative Therapy
Study Type: Interventional
Study Design: Treatment
Official Title: Phase III Randomized Study of Carboplatin and Vincristine Versus Thioguanine, Procarbazine, Lomustine, and Vincristine in Children With Progressive Low Grade Astrocytoma
Further Study Details:
OBJECTIVES:
- Compare the event free survival as a result of treatment with carboplatin and vincristine versus thioguanine, procarbazine, lomustine, and vincristine in children with progressive brain tumors.
- Estimate tumor response rates to each regimen of chemotherapy in these patients.
- Determine toxic effects and quality of life of children treated with each regimen of chemotherapy.
- Investigate biological and clinical factors which may predict tumor response and early progression (tumor size, location, pathologic subtype, cytogenetics, and proliferative index by MIB-1 (Ki67)) in these patients.
- Investigate factors contributing to neuropsychological and endocrine status of children with brain tumors treated without irradiation.
OUTLINE: This is a randomized study. Patients are stratified according to site of disease, status at entry, and pathology. Patients are randomized to one of two treatment arms. Patients with neurofibromatosis are nonrandomly assigned to arm II.
- Arm I: Patients receive induction with carboplatin and vincristine for 10 weeks followed by 2 weeks of rest. Induction is followed by 8 courses of maintenance beginning on day 84 of induction or upon hematopoietic recovery. Each course consists of 4 weekly doses of carboplatin and 3 weekly doses of vincristine (given concurrently with the first 3 weeks of carboplatin), followed by 2 weeks of rest.
- Arm II: Patients receive oral thioguanine, procarbazine, and lomustine on days 0-4, followed by vincristine IV on days 14 and 28. Treatment continues every 6 weeks for a maximum of 8 courses.
PROJECTED ACCRUAL: A total of 280-340 patients will be accrued over 4 years.
Eligibility
Ages Eligible for Study: up to 9 Years, Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
- Pathologically confirmed low grade residual astrocytomas or other eligible residual tumors of the brain interpreted as low grade (WHO grades I and II) such as the following:
- Glial Tumors
- Astrocytic tumors
- Low grade astrocytoma (variants: fibrillary, protoplasmic, gemistocytic)
- Pilocytic astrocytoma
- Pleomorphic xanthoastrocytomas
- Subependymal giant cell astrocytoma
- Infantile desmoplastic astrocytoma
- Low grade oligodendroglial tumors
- Low grade oligodendroglioma
- Low grade mixed gliomas
- Oligo-astrocytoma
- Neuronal Tumors
- Ganglioglioma (excluding tumors with anaplastic astrocytic components)
- Infantile desmoplastic ganglioglioma
- Chiasmatic-hypothalamic tumor without histologic confirmation
- All of the following diagnostic tests (radiological or clinical evidence of progression, surgery, or confirmatory MRI) must be carried out within 6 weeks of enrollment into this study
- Progressive disease following surgical excision based on clear radiological or clinical evidence of progression, or an incomplete excision (less than 95% or greater than 1.5 cm2) with necessity to begin treatment because of a risk of neurologic impairment with progression
- Chiasmatic lesions that have contiguous extensions of tumor into other regions of the visual pathways demonstrated on contrast MRI will be eligible for study without histopathological confirmation
- Patients with neurofibromatosis who have radiographic diagnosis of chiasmatic-hypothalamic tumor are eligible for the study, without requiring a biopsy confirmation of tumor histology, but not unless tumor progression is documented radiographically
- No intrinsic brain stem tumors of the pons or isolated optic nerve tumors without definitive involvement of the optic chiasm
PATIENT CHARACTERISTICS: Age:
- Under 10
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Absolute neutrophil count greater than 1,000/mm^3 (arm II)
- Platelet count greater than 100,000/mm^3 (arm II)
Hepatic:
- Not specified
Renal:
- Creatinine less than 1.5 times upper limit of normal for age OR
- Creatinine clearance or radioisotope GFR greater than 70 mL/min or equivalent GFR as determined by the institutional normal range
PRIOR CONCURRENT THERAPY: Biologic therapy:
- Not specified
Chemotherapy:
- No prior chemotherapy for the tumor
Endocrine therapy:
- Prior corticosteroid therapy allowed
Radiotherapy:
- No prior radiotherapy for the tumor
Surgery:
- See Disease Characterisitcs
Other:
Location and Contact Information
Arizona
Phoenix Children's Hospital, Phoenix, Arizona, 85016, United States; Recruiting
Dale Anne Singer, MD 602-546-0920
California
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center, Orange, California, 92868, United States; Recruiting
Stanley Calderwood, MD 714-456-6615 scalderw@uci.edu
Children's Hospital and Research Center at Oakland, Oakland, California, 94609-1809, United States; Recruiting
James H. Feusner, MD 510-428-3000 jfeusner@mail.cho.org
Children's Hospital Central California, Madera, California, 93638-8762, United States; Recruiting
Vonda Lee Crouse, MD 559-353-5480 vcrouse@childrenscentralcal.org
Children's Hospital Los Angeles, Los Angeles, California, 90027-0700, United States; Recruiting
Paul S. Gaynon, MD 323-669-2163 pgaynon@chla.usc.edu
Children's Hospital of Orange County, Orange, California, 92868, United States; Recruiting
Wei-Ping Violet Shen, MD 714-516-4348 vshen@choc.org
City of Hope Comprehensive Cancer Center, Duarte, California, 91010-3000, United States; Recruiting
Clinical Trials Office - New Patient Services 800-826-4673 becomingapatient@coh.org
General Robert Huyser Cancer Center at David Grant Medical Center, Travis Air Force Base, California, 94535, United States; Recruiting
Peter J. Chenaille, MD 707-423-7176
Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, 90095-1781, United States; Recruiting
Stephen A. Feig, MD 310-825-5268
Kaiser Permanente Medical Center - Sacramento, Sacramento, California, 95825, United States; Recruiting
Vincent A. Kiley, MD 916-973-7331 vincent.kiley@kp.org
Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, 95051-5386, United States; Recruiting
Carolyn Lucille Russo, MD 408-236-5028 carolyn.l.russo@kp.org
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego, San Diego, California, 92120, United States; Recruiting
Wellington Loh, MD 619-516-6144
Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda, California, 92354, United States; Recruiting
Antranik Bedros, MD 909-558-8626 abedro@ahs.llumc.edu
Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, Los Angeles, California, 90048, United States; Recruiting
Moshe Arditi, MD 310-423-4471
Santa Barbara Cottage Hospital, Santa Barbara, California, 93102, United States; Recruiting
Felicity Hodder, MD 805-682-7111 fhodder@cottagehealthsystem.org
Southern California Permanente Medical Group, Downey, California, 90242, United States; Recruiting
Willye B. Powell, MD 562-803-2472
UCSF Comprehensive Cancer Center, San Francisco, California, 94143, United States; Recruiting
Katherine K. Matthay, MD 415-476-3831
Colorado
Children's Hospital Cancer Center, Denver, Colorado, 80218, United States; Recruiting
Roger Howard Giller, MD 303-861-6892 giller.roger@tchden.org
Presbyterian - St. Luke's Medical Center, Denver, Colorado, 80218, United States; Recruiting
Stephen R. Palmer, MD 719-471-2462
Connecticut
Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center, Farmington, Connecticut, 06360-7106, United States; Recruiting
Arnold J. Altman, MD 860-545-9630
District of Columbia
Children's National Medical Center, Washington, District of Columbia, 20010-2970, United States; Recruiting
Nita Louise Seibel, MD 202-884-2144 nseibel@cnmc.org
Lombardi Cancer Center at Georgetown University Medical Center, Washington, District of Columbia, 20007, United States; Recruiting
Aziza Shad, MD 202-444-2224 shada@georgetown.edu
Florida
Broward General Medical Center, Fort Lauderdale, Florida, 33316, United States; Recruiting
Rudolph R. Roskos, MD 954-355-4527 rroskos@nbhd.org
Georgia
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Scottish Rite Campus, Atlanta, Georgia, 30342, United States; Recruiting
Howard M. Katzenstein, MD 404-785-0853 howard.katzenstein@choa.org
Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center, Savannah, Georgia, 31405, United States; Recruiting
Tribhawan S. Vats, MD 912-350-8194 vatsri@memorialhealth.com
MBCCOP-Medical College of Georgia Cancer Center, Augusta, Georgia, 30912-4000, United States; Recruiting
Roger A. Vega, MD 706-721-3626
Medical Center of Central Georgia, Macon, Georgia, 31201, United States; Recruiting
Hassan Dannawi, MD 478-633-1104 dannawi.hassan@mccg.org
Idaho
Mountain States Tumor Institute - Boise, Boise, Idaho, 83712, United States; Recruiting
J. Martin Johnston, MD 208-381-2782 johnstom@slrmc.org
Illinois
Lutheran General Cancer Care Center, Park Ridge, Illinois, 60068-1174, United States; Recruiting
Jong-Hyo Kwon, MD 847-723-5962 jong-hyo.kwon_md@advocatehealth.com
Southern Illinois University School of Medicine, Springfield, Illinois, 62794-9658, United States; Recruiting
Gregory Brandt, MD 217-545-5817 gbrandt@siumed.edu
University of Chicago Cancer Research Center, Chicago, Illinois, 60601, United States; Recruiting
James B. Nachman, MD 773-702-6808
University of Illinois Medical Center, Chicago, Illinois, 60612, United States; Recruiting
Mary Lou Schmidt, MD 312-996-6143 mls3@uic.edu
Indiana
Riley Children Cancer Center at Riley Hospital for Children, Indianapolis, Indiana, 46202-5225, United States; Recruiting
Robert Fallon, MD, PhD 317-274-8784 rfallon@iupui.edu
Iowa
Blank Children's Hospital, Des Moines, Iowa, 50308, United States; Recruiting
Torrey Leighton Mitchell, MD 515-241-8912 mitchetl@ihs.org
Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, 52242-1009, United States; Recruiting
Raymond Tannous, MD 319-356-1905
Kentucky
Kosair Children's Hospital, Louisville, Kentucky, 40202-3830, United States; Recruiting
Salvatore J. Bertolone, MD 502-852-8450
Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington, Kentucky, 40536-0284, United States; Recruiting
Martha F. Greenwood, MD 859-323-6771 mfgree0@pop.uky.edu
Louisiana
MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, 70112, United States; Recruiting
Jill Gilbert, MD 504-568-5613 jgilbe@lsuhsc.edu
Maryland
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital, Baltimore, Maryland, 21215, United States; Recruiting
Joseph Michael Wiley, MD 410-601-5864 jwiley@lifebridehealth.org
Massachusetts
Baystate Regional Cancer Program at D'Amour Center for Cancer Care, Springfield, Massachusetts, 01107, United States; Recruiting
David A. Steele, MD 413-794-9338 david.steele@bhs.org
Michigan
Breslin Cancer Center at Ingham Regional Medical Center, Lansing, Michigan, 48910, United States; Recruiting
Renuka Gera, MD 517-334-2337
Bronson Methodist Hospital, Kalamazoo, Michigan, 49007-5364, United States; Recruiting
Leonard August Mattano, MD, PhD 616-341-6350
CCOP - Beaumont, Royal Oak, Michigan, 48073-6769, United States; Recruiting
Jeanne Archer, PhD, APN 248-551-8299 carcher@beaumon.edu
DeVos Children's Hospital, Grand Rapids, Michigan, 49503, United States; Recruiting
David Robert Freyer, DO 616-391-2086
Josephine Ford Cancer Center at Henry Ford Health System, Detroit, Michigan, 48202, United States; Recruiting
Hassan M. Yaish, MD 313-916-3138
University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, 48109-0914, United States; Recruiting
Raymond J. Hutchinson, MD 734-936-8785
William Beaumont Hospital - Royal Oak, Royal Oak, Michigan, 48073-6769, United States; Recruiting
Charles A. Main, MD 248-551-0360
Minnesota
Children's Hospitals and Clinics - Minneapolis/St. Paul, Minneapolis, Minnesota, 55404, United States; Recruiting
Maura C. O'Leary, MD 612-813-5940
Mayo Clinic Cancer Center, Rochester, Minnesota, 55905, United States; Recruiting
Carola A.S. Arndt, MD 507-284-2511 carndt@mayo.edu
St. Mary's - Duluth Clinic Cancer Center, Duluth, Minnesota, 55805, United States; Recruiting
Jacquelyn Dawn Wiermaa, MD 218-786-3625
University of Minnesota Cancer Center, Minneapolis, Minnesota, 55455, United States; Recruiting
Joseph P. Neglia, MD, MPH 612-625-6903 jneglia@umn.edu
Missouri
Children's Mercy Hospital, Kansas City, Missouri, 64108, United States; Recruiting
Maxine L. Hetherington, MD 816-234-3265
Nebraska
Children's Hospital of Omaha, Omaha, Nebraska, 68114, United States; Recruiting
Minnie Abromowitch, MD 402-955-3949 mabromo@unmc.edu
UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha, Nebraska, 68198-2168, United States; Recruiting
Peter F. Coccia, MD 402-559-7257 pcoccia@unmc.edu
Nevada
Sunrise Hospital and Medical Center, Las Vegas, Nevada, 89109, United States; Recruiting
Jonathan Bernstein, MD 702-732-0971 jonbern1@aol.com
New Jersey
Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick, New Jersey, 08903, United States; Recruiting
Richard A. Drachtman, MD 732-235-5437 drachtri@umdnj.edu
Newark Beth Israel Medical Center, Newark, New Jersey, 07112-2094, United States; Recruiting
Peri Kamalakar, MD 973-926-7161 pkamalak@sghcs.com
St. Barnabas Medical Center, Livingston, New Jersey, 07039, United States; Recruiting
Brenda Sison, MD 973-322-2800
St. Joseph's Hospital and Medical Center, Paterson, New Jersey, 07503, United States; Recruiting
Mary Ann Bonilla, MD 973-754-3230 bonillam@sjhmc.org
Valerie Fund Children's Center at Atlantic Health, Summit, New Jersey, 07901, United States; Recruiting
Hazem Helmy Mahmoud, MD 973-971-6731
New York
Albert Einstein Cancer Center at Albert Einstein College of Medicine, Bronx, New York, 10461, United States; Recruiting
Eva Radel, MD 718-920-7844
Brookdale University Hospital and Medical Center, Brooklyn, New York, 11212, United States; Recruiting
Kusum Viswanathan, MD 718-240-5904
Brooklyn Hospital Center, Brooklyn, New York, 11201-5493, United States; Recruiting
Swayamprabha Sadanandan, MD 718-250-6074 sws9001@nyp.org
Cancer Center of Albany Medical Center, Albany, New York, 12208, United States; Recruiting
Jennifer M. Pearce, MD 518-262-5513 pearcej@mail.amc.edu
Comprehensive Cancer Center at Maimonides Medical Center, Brooklyn, New York, 11219, United States; Recruiting
Ludovico Guarini, MD 718-283-8173 lguarini@maimonidesmed.org
Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York, 10032, United States; Recruiting
Linda Granowetter, MD 212-305-8652 lg519@columbia.edu
Long Island Cancer Center at Stony Brook University Hospital, Stony Brook, New York, 11794, United States; Recruiting
Robert Ingalls Parker, DSc 631-444-4000
Memorial Sloan-Kettering Cancer Center, New York, New York, 10021, United States; Recruiting
Peter G. Steinherz, MD 212-639-7951
New York Medical College, Valhalla, New York, 10595, United States; Recruiting
M. Fevzi Ozkaynak, MD 914-493-7997 mehmet_ozkaynak@nymc.edu
New York Weill Cornell Cancer Center at Cornell University, New York, New York, 10021, United States; Recruiting
Patricia J.V. Giardina, MD 212-746-3400
Schneider Children's Hospital, New Hyde Park, New York, 11042, United States; Recruiting
Arlene Sara Redner, MD 718-470-3460
SUNY Downstate Medical Center, Brooklyn, New York, 11203, United States; Recruiting
Sreedhar P. Rao, MD 718-270-1693
SUNY Upstate Medical University Hospital, Syracuse, New York, 13210, United States; Recruiting
Ronald L. Dubowy, MD 315-464-5294 dubowyr@upstate.edu
North Carolina
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, 28232-2861, United States; Recruiting
Daniel P. McMahon, MD 704-355-1130 dmcmahon@carolinas.org
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, 27599, United States; Recruiting
Stuart Gold, MD 919-966-0985 stubaby@med.unc.med
Mission Hospitals, Asheville, North Carolina, 28801, United States; Recruiting
Orren Beaty, DO, PhD 823-213-5770 orren.beaty@msj.org
North Dakota
Dakota Cancer Institute at Innovis Health - Dakota Clinic, Fargo, North Dakota, 58103-4940, United States; Recruiting
Janet K. Tillisch, MD 701-364-4964
Meritcare Roger Maris Cancer Center, Fargo, North Dakota, 58122, United States; Recruiting
Nathan L. Kobrinsky, MD 701-234-2735
Ohio
Children's Hospital Medical Center of Akron, Akron, Ohio, 44308-1062, United States; Recruiting
Steven J. Kuerbitz, MD 330-543-8730 skuerbitz@chmca.org
Children's Medical Center - Dayton, Dayton, Ohio, 45404, United States; Recruiting
Emmett H. Broxson, MD, FAAP 937-641-3111 broxsone@childrensdayton.org
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229-3039, United States; Recruiting
John Peter Perentesis, MD 513-636-6090
Columbus Children's Hospital, Columbus, Ohio, 43205-2696, United States; Recruiting
Amanda Termuhlen, MD 614-722-3552
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio, 44106-5065, United States; Recruiting
Susan Wiersma, MD 216-844-3345 srw3@po.cwru.edu
St. Vincent Mercy Medical Center, Toledo, Ohio, 43608, United States; Recruiting
Rama Jasty, MD 419-251-8215 rjasty@mco.edu
Toledo Children's Hospital, Toledo, Ohio, 43601, United States; Recruiting
Richard M. Shore, MD 419-471-5437
Oregon
CCOP - Columbia River Oncology Program, Portland, Oregon, 97225, United States; Recruiting
Keith S. Lanier, MD 503-216-6260
Doernbecher Children's Hospital at Oregon Health & Science University, Portland, Oregon, 97239-3098, United States; Recruiting
H. Stacy Nicholson, MD, MPH 503-494-1543
Pennsylvania
Children's Hospital at Milton S. Hershey Medical Center, Hershey, Pennsylvania, 17033, United States; Recruiting
John E. Neely, MD 717-531-6012 jen6@psu.edu
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, United States; Recruiting
Richard Berry Womer, MD 215-590-2229 rwomer@mail.med.upenn.edu
Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15213, United States; Recruiting
Arthur Kim Ritchey, MD 412-692-5055 kim.ritchey@chp.edu
Geisinger Medical Center, Danville, Pennsylvania, 17822-1320, United States; Recruiting
Jeffrey Taylor, MD 570-271-6848
Rhode Island
Rhode Island Hospital, Providence, Rhode Island, 02903, United States; Recruiting
Sam W. Lew, MD 401-444-5171
South Dakota
Sioux Valley Hospital and University of South Dakota Medical Center, Sioux Falls, South Dakota, 57117-5039, United States; Recruiting
Jakica Tancabelic, MD 605-333-7171 jtancabe@usd.edu
Tennessee
East Tennessee Children's Hospital, Knoxville, Tennessee, 37901, United States; Recruiting
Ray C. Pais, MD 865-541-8266 hemonc@etch.com
East Tennessee State University Cancer Center at Johnson City Medical Center, Johnson City, Tennessee, 37614-0622, United States; Recruiting
David K. Kalwinsky, MD 423-433-6200 sjcrhta@msha,cin
Vanderbilt Children's Hospital, Nashville, Tennessee, 37232-6310, United States; Recruiting
James A. Whitlock, MD 615-936-1762
Texas
CCOP - Scott and White Hospital, Temple, Texas, 76508, United States; Recruiting
Lucas Wong, MD 254-724-1053 lwong@swmail.sw.org
Children's Hospital of Austin, Austin, Texas, 78701, United States; Recruiting
Sharon K. Lockhart, MD 512-324-8480 slockhart@stcaustin.com
Covenant Children's Hospital, Lubbock, Texas, 79410, United States; Recruiting
John Iacuone, MD 806-725-4840
MBCCOP - South Texas Pediatrics, San Antonio, Texas, 78229-3900, United States; Recruiting
Anne-Marie Langevin, MD 210-704-3405 langevin@uthscsa.edu
MD Anderson Cancer Center at University of Texas, Houston, Texas, 77030-4009, United States; Recruiting
Joann Ater, MD 713-792-6665 jater@mdanderson.org
Medical City Dallas Hospital, Dallas, Texas, 75230, United States; Recruiting
Carl Lenarsky, MD 972-566-6647 carl.lenarsky@usoncology.com
Methodist Cancer Center at Methodist Specialty and Transplant Hospital, San Antonio, Texas, 78229-3902, United States; Recruiting
Jaime Estrada, MD 210-575-8130
Texas Tech University Health Sciences Center School of Medicine, Amarillo, Texas, 79106, United States; Recruiting
Curtis Wade Turner, MD 806-354-5434 curtis.turner@ttuhsc.edu
Virginia
Children's Hospital of the King's Daughters, Norfolk, Virginia, 23507, United States; Recruiting
Rebecca L. Byrd, MD 757-668-7243 byrdrl@chkd.org
Washington
Children's Hospital and Regional Medical Center - Seattle, Seattle, Washington, 98105, United States; Recruiting
Douglas Hawkins, MD 206-987-3096
Deaconess Medical Center, Spokane, Washington, 99210-0248, United States; Recruiting
Steven K. Bergstrom, MD 509-473-7012 bergst@empirehealth.org
Group Health Central Hospital, Seattle, Washington, 98112, United States; Recruiting
Philip Herzog, MD 425-883-5291
Mary Bridge Children's Hospital and Health Center, Tacoma, Washington, 98415-0299, United States; Recruiting
William J. Thomas, MD 253-403-4915 hemonc@multicare.org
West Virginia
Cabell Huntington Hospital, Huntington, West Virginia, 25701, United States; Recruiting
Andrew Pendleton, MD 304-691-1384 dpendlet@marshall.edu
Mary Babb Randolph Cancer Center at West Virginia University Hospitals, Morgantown, West Virginia, 26506-9300, United States; Recruiting
Frank G. Keller, MD 304-293-1217
Wisconsin
Bellin Memorial Hospital, Green Bay, Wisconsin, 54301, United States; Recruiting
Dorothy J. Ganick, MD 920-433-6025
CCOP - Marshfield Clinic Research Foundation, Marshfield, Wisconsin, 54449, United States; Recruiting
Tarit Kumar Banerjee, MD, FACP 715-387-5511
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse, Wisconsin, 54601, United States; Recruiting
Robert S. Ettinger, MD 608-782-7300 rsetting@gundluth.org
Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin, 54449-5772, United States; Recruiting
Harlan James Nickerson, MD 715-387-5018
University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, 53792-6164, United States; Recruiting
Diane Puccetti, MD 608-263-0320
Australia, New South Wales
Sydney Children's Hospital, Randwick, New South Wales, 2031, Australia; Recruiting
Glenn Marshall, MD, MBBS 61-2-9382-1721 g.marshall@unsw.edu.au
Australia, Western Australia
Princess Margaret Hospital for Children, Perth, Western Australia, 6001, Australia; Recruiting
David L. Baker, MD, MBBS, FRACP, FRCPA 61-8-9340-8234
Canada, British Columbia
British Columbia Children's Hospital, Vancouver, British Columbia, V6H 3V4, Canada; Recruiting
Paul C.J. Rogers, MB, ChB, FRCPC, MBA, FRCP 604-875-2322 progers@cw.bc.ca
Canada, Manitoba
CancerCare Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada; Recruiting
Rochelle A. Yanofsky, MD 204-787-4163 rochelle.yanofsky@cancercare.mb.ca
Canada, Newfoundland and Labrador
Janeway Children's Health and Rehabilitation Centre, St. John's, Newfoundland and Labrador, A1B 3V6, Canada; Recruiting
John (Jack) Hand, MD 709-777-4799 hcc.hanjg@hccsj.nf.ca
Canada, Nova Scotia
IWK Health Centre, Halifax, Nova Scotia, B3J 3G9, Canada; Recruiting
Dorothy R. Barnard, MD 902-470-8291 dorothy.barnard@iwk.nshealth.ca
Canada, Ontario
Children's Hospital of Western Ontario, London, Ontario, N6C 2V5, Canada; Recruiting
Anne Elizabeth Lois Cairney, MD 519-685-8494 beth.cairney@lhsc.on.ca
Canada, Saskatchewan
Allan Blair Cancer Centre at Pasqua Hospital, Regina, Saskatchewan, S4T 7T1, Canada; Recruiting
Christina Ten Suan Goh, MD 306-766-2205 tgoh@scf.sk.ca
Saskatoon Cancer Centre, Saskatoon, Saskatchewan, S7N 4H4, Canada; Recruiting
Ali S. Kaiser, MD 306-655-2684
New Zealand
Starship Children's Health, Auckland, New Zealand; Recruiting
Lochie Teague, MD 64-9-307-4949 ext. 6295 lochiet@adhb.govt.nz
Switzerland
Swiss Pediatric Oncology Group Bern, Bern, CH 3010, Switzerland; Recruiting
Annette Ridolfi-Luethy, MD 41-31-632-9372
Swiss Pediatric Oncology Group Geneva, Geneva, CH 1211, Switzerland; Recruiting
Pierre Wacker, MD 41-22-382-3311
Swiss Pediatric Oncology Group Lausanne, Lausanne, CH 1011, Switzerland; Recruiting
Maja Beck Popovic, MD 41-21-314-3567
Study chairs or principal investigators
Joann Ater, MD, Study Chair, M.D. Anderson Cancer Center
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
Study ID Numbers: CDR0000065394; COG-A9952; CCG-A9952; POG-A9952; CCG-9952; NCT00002944
Record last reviewed: May 2004
Last Updated: April 4, 2005
Record first received: November 1, 1999
ClinicalTrials.gov Identifier: NCT00002944
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Record last reviewed: May 2004
Last Updated: April 4, 2005
Record first received: November 1, 1999
ClinicalTrials.gov Identifier: NCT00002944
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2005-04-08
Source: ClinicalTrials.gov
Cache Date: April 8, 2005
Resources
- TG (Drug Digest)
- Thioguanine (Drug Digest)
email this page
print this page
bookmark this page
feedback on this page
