This research project aims to study the effects of microdermabrasion, a technique causing minimal injury used to improve the appearance of fine lines, wrinkles, and scars. Subjects will undergo microdermabrasion, which is a gentle “sand-blasting” of the skin. We are interested in determining how this procedure works at rebuilding the skin following microdermabrasion.

Condition	Treatment or Intervention	Phase
healthy skin skin wrinkling	Procedure: Microdermabrasion	Phase II Phase III

Further Study Details: 

Primary Outcomes: Observing changes over time with respect to the following biochemical endpoints: Procollagen I and III, matrix metalloproteinases (MMPs 1, 3, and 9), and several cytokines including Interleukins and Tumor Necrosis Factor.
Secondary Outcomes: Changes in clinical features associated with sun-damaged or wrinkled skin.
Expected Total Enrollment:  260

Microdermabrasion is rapidly becoming one of the most popular cosmetic procedures performed by dermatologists and plastic surgeons. Microdermabrasion is a process that uses a high-pressure stream of aluminum oxide crystals and negative pressure to superficially peel the upper layer of the skin. Its purported benefits include improvement of photoaged skin, acne, and facial scarring. The appeal of microdermabrasion is its effectiveness, simplicity, low patient and operator risk, and rapid recovery. Clinically, studies have illustrated beneficial effects on photodamaged skin. Histologically, microdermabrasion has reproducible effects on the epidermis and dermis. Studies have shown a consistent increase in epidermal thickness as well as changes in the elastin content of the dermis while changes in collagen content have not been observed. The reported clinical and histologic changes seen in previous studies suggest that alterations in the dermis precipitated by epidermal injury may be responsible for the beneficial effects of microdermabrasion on photoaging and scarring. In fact, others have reported that skin fibroblasts under tension may increase collagen synthesis. Disruption of the epidermal barrier initiates a repair process that restores barrier function within hours to days, depending on the severity of the damage. This repair process involves increased synthesis of barrier lipids, followed by formation of new corneocytes. Elevated lipid synthesis largely occurs as a result of increased gene expression of the major enzymes responsible for lipid biosynthesis.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Accepts Healthy Volunteers

Criteria

Inclusion Criteria:

• Ages 18 or older
• Patients must be available for follow up visits for biopsies to comply with the requirements of the protocol.
• Patients must sign and understand the informed consent prior to participation in the study.

Exclusion Criteria:

• Oral retinoid (vitamin-A like drugs) use within one year of entry into the study
• Topical retinoid use within 3 months of the study
• Patients with a history of excessive scarring
• Patients with significant medical history or concurrent illness which investigators feel is not safe for study participation
• Patients who have had any type of facial rejuvenation procedure or treatment (such as Botox injections, collagen implants, or chemical peels) within the past six months
• Non-compliant patients
• Pregnant women

Please refer to this study by ClinicalTrials.gov identifier  NCT00111254

Ted A Hamilton, MS      734-936-6394    tedah@umich.edu

Michigan
      University of Michigan Department of Dermatology, Ann Arbor,  Michigan,  48109,  United States; Recruiting

Study ID Numbers:  Derm 486
Record last reviewed:  May 2005
Last Updated:  May 18, 2005
Record first received:  May 18, 2005
ClinicalTrials.gov Identifier:  NCT00111254
Health Authority: United States: Institutional Review Board (Awaiting confirmation)
ClinicalTrials.gov processed this record on 2005-05-24