Tolcapone

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Article: Tolcapone

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Tolcapone
Systematic (IUPAC) name
2-dihydroxyamino-4- (4-methylbenzoyl)- cyclohexa-2,4-diene-1,6-dione
Identifiers
CAS number	134308-13-7
ATC code	N04BX01
PubChem	4659569
DrugBank	APRD00445
Chemical data
Formula	C₁₄H₁₁NO₅
Mol. weight	273.241 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	2-3.5 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound with a relative molecular mass of 273.25. The chemical name of tolcapone is 3,4-dihydroxy-4’-methyl-5-nitrobenzophenone. Its empirical formula is C14H11NO5.

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