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Sodium Oxybate |
Xyrem |
Gamma-Hydroxybutyric acid Systematic (IUPAC) name 4-Hydroxybutanoic acid Identifiers CAS number 591-81-1 ATC code ?? PubChem 3037032 DrugBank ? Chemical data Formula C4H8O3 Mol. weight 104.11 Pharmacokinetic data Bioavailability ? Metabolism ? Half life ? Excretion ? Therapeutic considerations Pregnancy cat. ? Legal status Schedule I (USA); Class C (UK) Routes Usually Oral; IV GHB redirects here. See also Great High ...
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Sodium Oxybate Clinical Trials
- Trial of Xyrem® (Sodium Oxybate) for the Treatment of Narcolepsy
ClinicalTrials.gov Identifier: NCT00132873 - Recruiting
Narcolepsy
- Safety and efficacy of Xyrem oral solution (sodium oxybate) compared with placebo in narcoleptic patients
ClinicalTrials.gov Identifier: NCT00049803 - Completed
Narcolepsy
- Trial Comparing the Effects of Xyrem (sodium oxybate) with Placebo for the Treatment of Fibromyalgia
ClinicalTrials.gov Identifier: NCT00087555 - Completed
Fibromyalgia
- Exploratory Clinical Study to Evaluate Sodium Oxybate (Xyrem) on Potential Endocrine Changes
ClinicalTrials.gov Identifier: NCT00345800 - Recruiting
Narcolepsy With Cataplexy
- Safety and Efficacy Study of Xyrem® (Sodium Oxybate) in Subjects With Fibromyalgia.
ClinicalTrials.gov Identifier: NCT00423605 - Recruiting
Fibromyalgia
- A Safety and Efficacy Study of Xyrem® (Sodium Oxybate) to Treat Fibromyalgia.
ClinicalTrials.gov Identifier: NCT00423813 - Recruiting
Fibromyalgia
- Enhancing Slow Wave Sleep With Sodium Oxybate
ClinicalTrials.gov Identifier: NCT00506974 - Recruiting
Sleep
- Physiological, Behavioral and Subjective Effects of Drugs (GHB)
ClinicalTrials.gov Identifier: NCT00058955 - Recruiting
Sedative abuse
- Xyrem(Sodium Oxybate) and Ambien(Zolpidem Tartrate) in the Treatment of Chronic Insomnia.
ClinicalTrials.gov Identifier: NCT00383643 - Recruiting
Chronic Insomnia
- Sodium Oxybate in the Treatment of Binge Eating Disorder
ClinicalTrials.gov Identifier: NCT00514995 - Recruiting
Binge Eating Disorder
- Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
ClinicalTrials.gov Identifier: NCT00086281 - Active, not recruiting
Obstructive Sleep Apnea Syndrome
- Trial Comparing Effects of Xyrem taken Orally and Modafinil with Placebo in Treating Daytime Sleepiness in Narcolepsy
ClinicalTrials.gov Identifier: NCT00066170 - Completed
Narcolepsy
- A Study to Assess the Effect of Montelukast Sodium with Concomitant Administration of Inhaled Budesonide in Asthmatic Patients.
ClinicalTrials.gov Identifier: NCT00140946 - Active, not recruiting
Asthma
- Dietary Patterns, Sodium Intake and Blood Pressure (DASH - Sodium)
ClinicalTrials.gov Identifier: NCT00000608 - Active, not recruiting
Cardiovascular Diseases; Heart Diseases; Hypertension; Vascular Diseases
- Safety Study of Fondaparinux Sodium to Prevent Venous Thromboembolic Events (APOLLO)
ClinicalTrials.gov Identifier: NCT00038961 - Active, not recruiting
Venous Thrombosis
- Study of T900607-sodium in previously treated patients with ovarian cancer.
ClinicalTrials.gov Identifier: NCT00043446 - Active, not recruiting
Ovarian Neoplasms
- Extension Study of Enteric-Coated Mycophenolate Sodium With Short-Term or no Steroid Use Compared With Enteric-Coated Mycophenolate Sodium With Standard Steroid Therapy in de Novo Kidney Recipients
ClinicalTrials.gov Identifier: NCT00240955 - Active, not recruiting
Renal Transplantation
- Risedronate Sodium on Bone in Postmenopausal Women with Hormone-Receptor-Positive Early Breast Cancer
ClinicalTrials.gov Identifier: NCT00082277 - Active, not recruiting
Breast Cancer
- Study of T900607-sodium in chemotherapy naive patients with hepatocellular carcinoma.
ClinicalTrials.gov Identifier: NCT00043433 - Active, not recruiting
Hepatocellular Carcinoma
- T138067 Sodium in Treating Patients With Advanced Refractory Cancer
ClinicalTrials.gov Identifier: NCT00003359 - Active, not recruiting
Leukemia; Lymphoma; Multiple Myeloma
- Safety and Efficacy Study of the Use of Sodium Pyruvate Bronchodilation in Asthmatics
ClinicalTrials.gov Identifier: NCT00262652 - Active, not recruiting
Mild to Moderate Asthma
- Prevention of Contrast Nephropathy by Sodium Bicarbonate Versus Sodium Chloride and N-Acetylcysteine
ClinicalTrials.gov Identifier: NCT00353340 - Recruiting
Acute Renal Failure Contrast Nephropathy
- Follow-Up Study of Safety of Enteric-Coated Mycophenolate Sodium in Patients Who Successfully Completed Study CERL080A301
ClinicalTrials.gov Identifier: NCT00149929 - Active, not recruiting
Renal transplant
- Follow-Up Study of Safety of Enteric-Coated Mycophenolate Sodium in Patients Who Successfully Completed Study CERL080A0107
ClinicalTrials.gov Identifier: NCT00149916 - Active, not recruiting
Renal transplant
- Follow-Up Study of Safety of Enteric-Coated Mycophenolate Sodium in Patients Who Successfully Completed Study CERL080A302
ClinicalTrials.gov Identifier: NCT00149864 - Active, not recruiting
Renal transplant
- Study Conducted in China of the Efficacy and Safety of Enteric-Coated Mycophenolate Sodium Versus Mycophenolate Mofetil in Adult De Novo Renal Transplant Patients
ClinicalTrials.gov Identifier: NCT00149903 - Active, not recruiting
Renal transplant
- A One-Year, Open Label Study to Investigate the Safety and the Effect of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Combination with Cyclosporine Microemulsion in De Novo Kidney Transplant Recipients.
ClinicalTrials.gov Identifier: NCT00154245 - Active, not recruiting
Kidney Transplantation
- Pegaptanib Sodium (Macugen) Compared to Sham Injection in Patients with Diabetic Macular Edema (DME) Involving the Center of the Macula
ClinicalTrials.gov Identifier: NCT00148811 - Active, not recruiting
Diabetic Macular Edema
- Genasense™ (Oblimersen Sodium), Fludarabine, and Rituximab in Subjects with Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00078234 - Active, not recruiting
Chronic Lymphocytic Leukemia
- Safety Study of Oral Sodium Phenylbutyrate in Subjects with ALS (Amyotrophic Lateral Sclerosis)
ClinicalTrials.gov Identifier: NCT00107770 - Active, not recruiting
Amyotrophic Lateral Sclerosis
- Phase III Randomized Study of Sodium Dichloroacetate in Children with Congenital Lactic Acidosis
ClinicalTrials.gov Identifier: NCT00004490 - Active, not recruiting
Lactic Acidosis
- Dose-Response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room
ClinicalTrials.gov Identifier: NCT00135668 - Recruiting
Controlled Hypotension
- Conversion Trial from Mycophenolate Mofetil (MMF) to Enteric-Coated Mycophenolate Sodium (EC-MPS) in Stable Transplanted Patients Suffering from Gastrointestinal (GI) Adverse Events While on Mycophenolate Mofetil Therapy (MMF) Therapy.
ClinicalTrials.gov Identifier: NCT00149942 - Active, not recruiting
Kidney and liver transplantation
- Clinical Investigation Into the Efficacy and Tolerability of Inhaled Treprostinil Sodium in Patients with Severe PAH
ClinicalTrials.gov Identifier: NCT00147199 - Recruiting
Pulmonary Arterial Hypertension
- Efficacy, Tolerability and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) with Cyclosporine Microemulsion and Steroids in Pediatric De Novo Renal Transplant Patients
ClinicalTrials.gov Identifier: NCT00154206 - Active, not recruiting
De novo pediatric renal transplantation
- Safety and Tolerability of Enteric-Coated Mycohenolate Sodium (EC-MPS) in Renal Transplant Patients with GI Intolerance
ClinicalTrials.gov Identifier: NCT00150020 - Recruiting
Renal Transplantation
- Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
ClinicalTrials.gov Identifier: NCT00004493 - Recruiting
Lactic Acidosis
- Effects of Divalproex Sodium on Food Intake, Energy Expenditure, and Posture Allocation
ClinicalTrials.gov Identifier: NCT00287053 - Active, not recruiting
Healthy
- A Study of Sitaxsentan Sodium in Subjects With Diastolic Heart Failure
ClinicalTrials.gov Identifier: NCT00303498 - Active, not recruiting
Ventricular Dysfunction, Left
- Sodium Stibogluconate and Interferon in Treating Patients With Advanced Solid Tumors, Lymphoma, or Myeloma
ClinicalTrials.gov Identifier: NCT00311558 - Active, not recruiting
Cancer
- Extension Study on the Safety and Efficacy of Enteric-Coated Mycophenolate Sodium in Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00239070 - Active, not recruiting
Renal Transplantation
- Extension Study of the Safety and Efficacy of Enteric-Coated Mycophenolate Sodium in Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00241059 - Active, not recruiting
Renal Transplantation
- Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet
ClinicalTrials.gov Identifier: NCT00518765 - Active, not recruiting
Hypertension
- Sodium Salicylate in Treating Patients With Advanced Myelodysplastic Syndrome, Acute Myelogenous Leukemia, or Chronic Lymphocytic Leukemia
ClinicalTrials.gov Identifier: NCT00004245 - Active, not recruiting
adult acute myeloid leukemia; atypical chronic myeloid leukemia; childhood acute myeloid leukemia and other myeloid malignancies; ...
- Effect of Nitrite on Exercise Physiology and Metabolism
ClinicalTrials.gov Identifier: NCT00105222 - Active, not recruiting
- Nitrite Infusion Studies
ClinicalTrials.gov Identifier: NCT00102271 - Active, not recruiting
- Safety and Efficacy of Enteric-Coated Mycophenolate Sodium (EC-MPS) Plus Valsartan in Patients With Kidney Transplants (MYTHOS
ClinicalTrials.gov Identifier: NCT00308425 - Active, not recruiting
De Novo Renal Transplantation
- Phase II Randomized Study of Alendronate Sodium for Osteopenia in Patients with Gaucher's Disease
ClinicalTrials.gov Identifier: NCT00004488 - Recruiting
Gaucher's Disease; Osteopenia
- Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00229138 - Active, not recruiting
Kidney Transplantation
- A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.
ClinicalTrials.gov Identifier: NCT00330460 - Active, not recruiting
Osteoporosis; Osteopenia
- Photodynamic Therapy Using Porfimer Sodium in Treating Patients Who Are Undergoing Surgery for Recurrent Malignant Astrocytoma
ClinicalTrials.gov Identifier: NCT00118222 - Active, not recruiting
Mixed Gliomas; adult anaplastic astrocytoma; recurrent adult brain tumor; adult giant cell glioblastoma; adult gliosarcoma
- Dialysate Sodium Individualization in Hemodialysis
ClinicalTrials.gov Identifier: NCT00259714 - Recruiting
Hypertension in Hemodialysis Patients
- Double-Blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
ClinicalTrials.gov Identifier: NCT00194116 - Active, not recruiting
Bipolar Disorder
- Phase II Study of Sodium Phenylbutyrate, Sodium Benzoate, Sodium Phenylacetate, and Dietary Intervention for Urea Cycle Disorders
ClinicalTrials.gov Identifier: NCT00004767 - Completed
Amino Acid Metabolism, Inborn Errors
- A Multicenter, Randomized Placebo Controlled Pilot MicroCT Study to Estimate the Effect of Treatment With Denosumab (AMG 162) and Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density
ClinicalTrials.gov Identifier: NCT00293813 - Active, not recruiting
Osteoporosis
- Extension Study of Enteric-Coated Mycophenolate Sodium in Combination With Full Dose or Reduced Dose Cyclosporine Microemulsion in Patients With de Novo Kidney Transplants
ClinicalTrials.gov Identifier: NCT00238940 - Active, not recruiting
Renal Transplantation
- Pleurectomy/Decortication With or Without Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate
ClinicalTrials.gov Identifier: NCT00165503 - Active, not recruiting
Pleural Mesothelioma; Malignant Pleural Mesothelioma
- Extrapleural Pneumonectomy With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Amifostine and Sodium Thiosulfate
ClinicalTrials.gov Identifier: NCT00165516 - Active, not recruiting
Pleural Mesothelioma; Malignant Pleural Mesothelioma
- Extension Study to Assess Tolerability and Safety of Enteric-Coated Mycophenolate Sodium in Renal Transplant Recipients Who Received Mycophenolate Mofetil
ClinicalTrials.gov Identifier: NCT00238966 - Active, not recruiting
Renal Transplantation
- Study of Enteric-Coated Mycophenolate Sodium Maintenance Therapy in Patients With Renal Transplant Receiving Cyclosporine Microemulsion and Steroids,
ClinicalTrials.gov Identifier: NCT00239057 - Active, not recruiting
Maintenance Renal Transplantation
- Enteric-Coated Mycophenolate Sodium on Quality of Life in Patients With Gastrointestinal Symptoms Related to Mycophenolate Mofetil Therapy After Kidney Transplantation
ClinicalTrials.gov Identifier: NCT00239005 - Not yet recruiting
Renal Transplant
- Clinical Study to Evaluate the Tolerability, Safety and Efficacy of Enteric-Coated Mycophenolate Sodium After Equimolar Conversion From Mycophenolate Mofetil (MMF) in Patients With Renal Transplant
ClinicalTrials.gov Identifier: NCT00171379 - Active, not recruiting
Prevention of Acute Rejection After Kidney Transplantation
- Clinical Study to Evaluate the Tolerability, Safety and Efficacy of Enteric-Coated Mycophenolate Sodium, After Equimolar Conversion From Mycophenolate Mofetil (MMF), in Patients With Stable Renal Transplant Receiving Tacrolimus
ClinicalTrials.gov Identifier: NCT00171392 - Active, not recruiting
Prevention of Acute Rejection After Kidney Transplantation
- Extension Study on the Efficacy and Safety of Enteric-Coated Mycophenolate Sodium Administered in de Novo Kidney Transplant Patients
ClinicalTrials.gov Identifier: NCT00239018 - Active, not recruiting
De Novo Kidney Transplantation
- Sodium Channel Expression in Human Teeth
ClinicalTrials.gov Identifier: NCT00575263 - Recruiting
Dental Pulp Disease
- ATX-101 (Sodium Deoxycholate for Injection) for the Treatment of Superficial Lipomas
ClinicalTrials.gov Identifier: NCT00422188 - Recruiting
Lipoma
- Prevention of Contrast Induced Nephropathy With Sodium Bicarbonate
ClinicalTrials.gov Identifier: NCT00472563 - Recruiting
Acute Kidney Failure
- Sodium Thiosulfate Treatment of Vascular Calcification in ESRD
ClinicalTrials.gov Identifier: NCT00568399 - Recruiting
Hemodialysis; Cardiovascular Diseases
- Corticosteroid Therapy of Septic Shock - Corticus
ClinicalTrials.gov Identifier: NCT00147004 - Active, not recruiting
Shock, Septic
- Ketoconazole With or Without Alendronate Sodium in Treating Patients With Metastatic Prostate Cancer
ClinicalTrials.gov Identifier: NCT00019695 - Active, not recruiting
Stage IV Prostate Cancer; Bone Metastases; Adenocarcinoma of the Prostate; Recurrent Prostate Cancer
- Boronophenylalanine-Fructose Complex (BPA-F) and/or Sodium Borocaptate (BSH) Followed By Surgery in Treating Patients With Thyroid Cancer, Head and Neck Cancer, or Liver Metastases
ClinicalTrials.gov Identifier: NCT00062348 - Recruiting
Endocrine Cancer; Gastrointestinal Cancer; Head and Neck Cancer; metastatic cancer
- Formation and Severity of Pressure Ulcers Associated With 4% Albumin Vs. 0.9% Sodium Chloride
ClinicalTrials.gov Identifier: NCT00228657 - Active, not recruiting
Pressure Ulcer, Area; Pressure Ulcer, Grade; Albumin Level; Risk Score; Length of ICU Stay
- The Efficacy Study of Sodium Hyaluronate to Treat Symptomatic Hip Osteoarthritis
ClinicalTrials.gov Identifier: NCT00330135 - Active, not recruiting
Symptomatic Hip Osteoarthritis
- Efficacy of Combination Product (Sumatriptan Succinate/Naproxen Sodium) in Eletriptan Non-Responders.
ClinicalTrials.gov Identifier: NCT00382993 - Recruiting
Migraine
- Efficacy of Combination Product (Sumatriptan Succinate/Naproxen Sodium) in Eletriptan Non-Responders.
ClinicalTrials.gov Identifier: NCT00383162 - Recruiting
Migraine
- Sodium Phenylbutyrate for Treating Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder
ClinicalTrials.gov Identifier: NCT00345605 - Active, not recruiting
Argininosuccinic Aciduria; Amino Acid Metabolism, Inborn Errors; Urea Cycle Disorders
- Clinical Trial of Sodium Bicarbonate to Prevent Contrast-Induced Nephropathy
ClinicalTrials.gov Identifier: NCT00424320 - Recruiting
Acute Kidney Failure
- Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors
ClinicalTrials.gov Identifier: NCT00238173 - Active, not recruiting
Bone Marrow Suppression; Brain and Central Nervous System Tumors; Drug Toxicity; Long-Term Effects Secondary to Cancer Therapy in Children
- An Approved Drug to Study a New Indication for Allergic Rhinitis
ClinicalTrials.gov Identifier: NCT00127647 - Active, not recruiting
Rhinitis, Allergic, Seasonal
- Effect of High and Low Sodium Diets on Blood Pressure in Hypertensive Patients Treated With Aliskiren
ClinicalTrials.gov Identifier: NCT00441064 - Recruiting
Hypertension
- Study to Assess Effects of Age, Weight, and Body Composition on the Pharmacokinetics of IV Diclofenac Sodium
ClinicalTrials.gov Identifier: NCT00509743 - Recruiting
Healthy
- Gene Therapy for the Treatment of Brain Tumors
ClinicalTrials.gov Identifier: NCT00001328 - Active, not recruiting
Brain Neoplasm; Neoplasm Metastasis
- Safety and Efficacy of Risedronate in the Treatment of Osteogenesis Imperfecta in Children
ClinicalTrials.gov Identifier: NCT00106028 - Active, not recruiting
Osteogenesis Imperfecta
- Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in Renal Transplant Patients
ClinicalTrials.gov Identifier: NCT00239083 - Recruiting
Kidney Transplantation
- Study Evaluating Pantoprazole Sodium Enteric-Coated Spheroid Suspension In Infants With Presumed GERD
ClinicalTrials.gov Identifier: NCT00259012 - Recruiting
Gastroesophageal Reflux
- Effects of Sodium Intake on(PK)/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker
ClinicalTrials.gov Identifier: NCT00310778 - Recruiting
Healthy
- Low Sodium Diet and Behavioral Intervention for Reversing Arterial Stiffening in Overweight Individuals
ClinicalTrials.gov Identifier: NCT00366990 - Recruiting
Cardiovascular Diseases; Obesity
- A Prospective Study of the Effect of Topical Sodium Hyaluronate Immediately Post-PKP on Time to Reepithelialization
ClinicalTrials.gov Identifier: NCT00570648 - Recruiting
Corneal Transplantation
- Comparison of Study Drug With Alendronate on How it Effects Glucocorticoid-Induced Osteoporosis
ClinicalTrials.gov Identifier: NCT00051558 - Active, not recruiting
Osteoporosis
- Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in de Novo Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00312143 - Active, not recruiting
De Novo Kidney Transplant Recipients
- Carboplatin, Cyclophosphamide, and Etoposide or Etoposide Phosphate With or Without Sodium Thiosulfate in Treating Patients With High-Grade Glioma
ClinicalTrials.gov Identifier: NCT00075387 - Recruiting
adult anaplastic astrocytoma; adult anaplastic ependymoma; adult anaplastic oligodendroglioma; adult brain tumor; adult glioblastoma; ...
- Efficacy and Safety of Enteric-Coated Mycophenolate Sodium (EC-MPS) in de Novo Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00238953 - Recruiting
Renal Transplantation
- A Study to Examine the Effectiveness and Safety of Oral Ibandronate Given Once Monthly in Postmenopausal Women with Osteopenia
ClinicalTrials.gov Identifier: NCT00129623 - Active, not recruiting
Bone Disease, Metabolic; Osteopenia
- A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients with AIDS Who Have Not Had Success with Ganciclovir
ClinicalTrials.gov Identifier: NCT00002301 - Active, not recruiting
Cytomegalovirus Retinitis; HIV Infections
- Study of the Safety and Effectiveness of Rabeprazole in Treatment of Helicobacter Pylori Infection in Adults.
ClinicalTrials.gov Identifier: NCT00216450 - Active, not recruiting
Bacterial Infections; Helicobacter Infections
- Investigation Into the Therapeutic Dosage of Fondaparinux Sodium, a Medication Used to Prevent Blood Clots in Morbidly Obese Volunteers
ClinicalTrials.gov Identifier: NCT00436787 - Recruiting
Venous Thrombosis; Pulmonary Embolism
- Risperidone and Divalproex Sodium With MRI Assessment in Pediatric Bipolar
ClinicalTrials.gov Identifier: NCT00176202 - Recruiting
Bipolar Disorder
- Urine Chloride/Creatinine Ratio for Estimation of Urine Sodium
ClinicalTrials.gov Identifier: NCT00324883 - Recruiting
Hypertension
- SOLID-Effect of Risedronate Sodium at Distal Radius in Colle's Fracture.
ClinicalTrials.gov Identifier: NCT00460733 - Recruiting
Colles' Fracture
- Safety and Efficacy of Sitaxsentan in the Treatment of Pulmonary Arterial Hypertension
ClinicalTrials.gov Identifier: NCT00034307 - Active, not recruiting
Pulmonary Hypertension
Resources
- Sodium Oxybate (Drug Digest)
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