Rapamune is used together with cyclosporine and a steroid medication to prevent your body from rejecting a kidney transplant.

Special Warnings Concerning Rapamune:

In order to prevent transplant rejection, Rapamune suppresses the body’s immune system. This also decreases the ability of the body's immune system to protect against other diseases. While taking Rapamune there is an increased risk of infection and possible development of lymphoma (cancer of the immune system).

General Precautions with Rapamune:

Rapamune can increase your blood cholesterol and triglyceride levels, which may require treatment.

Your doctor will monitor your kidney function and may adjust the dose of some of your immunosuppressant medications based on the test results.

Women of childbearing age should begin using an effective birth control method before starting to take Rapamune, continue during Rapamune treatment, and for 12 weeks after stopping Rapamune.

Before receiving any vaccinations, tell your doctor that you are taking Rapamune. Some vaccinations may be less effective during treatment with Rapamune, and certain vaccinations should be avoided.

Avoid sources of infection. Rapamune weakens your body's immune system and increases your risk of infection. Notify your doctor at the first sign of fever, chills, or a sore throat.