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Sirolimus |
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Sirolimus Systematic (IUPAC) name [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*, 19S*,26aR*]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5, 19-dihydroxy-3- [2-(4-hydroxy-3-methoxycyclohexyl) -1-methylethenyl]-14, 16-dimethoxy-4,10,12, 18-tetramethyl-8-(2-propenyl)-15, 19-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclotricosine-1,7,20, 21(4H,23H)-tetrone, monohydrate. Identifiers CAS number 53123-88-9 ATC code L04AA10 PubChem 6436030 DrugBank ...
Wikipedia - [full article]
Sirolimus Clinical Trials
- Efficacy and Safety of Sirolimus in Combination with Tacrolimus
ClinicalTrials.gov Identifier: NCT00141804 - Active, not recruiting
Kidney Transplantation
- Sirolimus Therapy for Idiopathic and Lupus Membranous Nephropathy
ClinicalTrials.gov Identifier: NCT00050713 - Active, not recruiting
Membranous Glomerulonephritis
- Long-term administration of sirolimus (rapamune™) in solid organ transplant recipients study
ClinicalTrials.gov Identifier: NCT00037531 - Active, not recruiting
Organ Transplantation
- Sirolimus in Treating Patients With Angiomyolipoma of the Kidney
ClinicalTrials.gov Identifier: NCT00126672 - Recruiting
Angiomyolipoma
- Evaluation of Calcineurin Inhibitor and Sirolimus (Rapamune) Treatment in Liver Allograft Recipients
ClinicalTrials.gov Identifier: NCT00086346 - Active, not recruiting
Liver Transplantation; Hepatic Transplantation
- Sirolimus and Thymoglobulin to Prevent Kidney Transplant Rejection
ClinicalTrials.gov Identifier: NCT00006178 - Active, not recruiting
Kidney Failure
- Study Evaluating Sirolimus in the Prevention of New Non-Melanoma Skin Cancer in Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00129961 - Active, not recruiting
NMSC in maintenance renal transplant recipients
- A Study to Compare Treatment with Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
ClinicalTrials.gov Identifier: NCT00005113 - Active, not recruiting
End-Stage Renal Disease; Kidney Transplantation
- Sirolimus as Secondary Therapy in Treating Patients With Chronic Graft-Versus-Host Disease That Did Not Respond to Previous Systemic Treatment
ClinicalTrials.gov Identifier: NCT00079183 - Active, not recruiting
Graft Versus Host Disease
- Use of Sirolimus vs. Tacrolimus For African-American Renal Transplant Recipients
ClinicalTrials.gov Identifier: NCT00252655 - Active, not recruiting
Kidney Transplantation
- Influence of Genes on Sirolimus Metabolism in Patients With Kidney Transplantation
ClinicalTrials.gov Identifier: NCT00352547 - Active, not recruiting
Renal Transplant
- Sirolimus in Treating Patients With Glioblastoma Multiforme
ClinicalTrials.gov Identifier: NCT00047073 - Active, not recruiting
recurrent adult brain tumor; adult glioblastoma; adult giant cell glioblastoma; adult gliosarcoma
- Sirolimus-Eluting BX VELOCITYTM Balloon-Expandable Stent in a Compassionate Use Registry (SECURE)
ClinicalTrials.gov Identifier: NCT00231244 - Active, not recruiting
Coronary Artery Disease
- Diabetes Drug Eluting Sirolimus Stent Experience in Restenosis Trial (The Dessert Study)
ClinicalTrials.gov Identifier: NCT00497172 - Active, not recruiting
Coronary Artery Disease
- Study of Unrelated Cord Blood Transplantation Using Tacrolimus and Sirolimus
ClinicalTrials.gov Identifier: NCT00133367 - Recruiting
Multiple Myeloma; Non-Hodgkin''s Lymphoma; Hodgkin''s Disease; Myelogenous Leukemia; Lymphoblastic Leukemia
- Sirolimus Blood Concentrations on Conversion From Oral Solution to Tablets
ClinicalTrials.gov Identifier: NCT00166842 - Active, not recruiting
Transplantation; Kidney Transplantation; Immunosuppression
- The Pharmacokinetics of Sirolimus When Combined With Cyclosporine or Tacrolimus in Renal Transplant Patients
ClinicalTrials.gov Identifier: NCT00166816 - Active, not recruiting
Transplantation; Kidney Transplantation; Immunosuppression
- Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant
ClinicalTrials.gov Identifier: NCT00188955 - Active, not recruiting
Kidney Transplantation
- Long Term Efficacy and Safety of Firebird Sirolimus-Eluting Stent In Complex Coronary Lesions
ClinicalTrials.gov Identifier: NCT00552656 - Active, not recruiting
Coronary Disease
- Sirolimus and Mycophenolate Mofetil as Graft Versus Host Disease Prophylaxis in Myeloablative Matched Related Donor Hematopoietic Cell Transplant
ClinicalTrials.gov Identifier: NCT00350181 - Active, not recruiting
Leukemia; Lymphoma, Non-Hodgkin
- Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants
ClinicalTrials.gov Identifier: NCT00433485 - Active, not recruiting
Neoplastic Syndrome; Non-Melanomatous Skin Cancer
- Sirolimus, Tacrolimus, and Methotrexate in Preventing Acute Graft-Versus-Host Disease in Patients With Hematologic Cancer Who are Undergoing Donor Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00089037 - Active, not recruiting
childhood Hodgkin's lymphoma; childhood non-Hodgkin's lymphoma; Graft Versus Host Disease; hematopoietic and lymphoid cancer
- Sirolimus-Eluting Stent vs. Intravascular Brachytherapy in In-Stent Restenotic Coronary Artery Lesions(SISR)
ClinicalTrials.gov Identifier: NCT00231257 - Active, not recruiting
In-Stent Restenosis
- The Effect of Sirolimus on the Pharmacokinetics of Tacrolimus
ClinicalTrials.gov Identifier: NCT00166829 - Recruiting
Kidney Transplantation
- Study of the 2.25mm Sirolimus-Eluting Stent in the Treatment of Patients With Coronary Artery Lesions
ClinicalTrials.gov Identifier: NCT00232739 - Active, not recruiting
Coronary Artery Disease
- Study of the 4.0mm Sirolimus-Eluting Stent in the Treatment of Patients With Coronary Artery Lesions
ClinicalTrials.gov Identifier: NCT00232752 - Active, not recruiting
Coronary Artery Disease
- Evaluation of Two Reduced Sirolimus Doses in Treatment of de Novo Coronary Artery Lesions (REDOX)
ClinicalTrials.gov Identifier: NCT00233766 - Active, not recruiting
Coronary Artery Disease
- To Compare the Efficacy and Safety of a Therapy of Tacrolimus With Sirolimus or MMF in Kidney Transplantation.
ClinicalTrials.gov Identifier: NCT00296361 - Active, not recruiting
Kidney Transplantation
- Double or Single Dose Sirolimus-Eluting Stents in Diabetic Patients With de Novo Coronary Artery Lesions
ClinicalTrials.gov Identifier: NCT00233714 - Active, not recruiting
Coronary Artery Disease
- Study of Sirolimus-Coated BX VELOCITY Balloon-Expandable Stent in Treatment of de Novo Native Coronary Artery Lesions (SIRIUS)
ClinicalTrials.gov Identifier: NCT00232765 - Active, not recruiting
Coronary Artery Disease
- MGA031, Sirolimus and Tacrolimus in Islet Transplantation
ClinicalTrials.gov Identifier: NCT00265473 - Recruiting
Type 1 Diabetes Mellitus; Hypoglycemia
- Sirolimus and MMF as GVHD Prophylaxis After RIC Transplantation
ClinicalTrials.gov Identifier: NCT00548717 - Recruiting
Graft-vs-Host Disease
- Sirolimus Eluting Stenting in Acute Myocardial Infarction
ClinicalTrials.gov Identifier: NCT00288210 - Active, not recruiting
Myocardial Infarction
- Phase 1 Study With Sorafenib and Sirolimus
ClinicalTrials.gov Identifier: NCT00509613 - Recruiting
Advanced Solid Tumor; Refractory to Standard Therapies
- Study Evaluating of Calcineurin Inhibitors Versus Sirolimus in Renal Allograft Recipient
ClinicalTrials.gov Identifier: NCT00452361 - Recruiting
Kidney Transplantation
- Sirolimus Based Immunosuppression for Patients Undergoing Kidney Transplantation in the Eurotransplant Senior Program
ClinicalTrials.gov Identifier: NCT00461357 - Active, not recruiting
Kidney Function After Transplantation; Outcome After Kidney Transplantation
- Improving Immunosuppressive Treatment for Patients with Severe Aplastic Anemia
ClinicalTrials.gov Identifier: NCT00061360 - Active, not recruiting
Aplastic Anemia
- Erlotinib and Sirolimus in Treating Patients With Recurrent Malignant Glioma
ClinicalTrials.gov Identifier: NCT00509431 - Recruiting
Brain and Central Nervous System Tumors
- Sirolimus-Based Immunosuppression Therapy in OLT for Patients With HCC Exceeding Milan Criteria
ClinicalTrials.gov Identifier: NCT00554125 - Recruiting
Hepatocellular Carcinoma
- Thymoglobulin, Sirolimus and Mycophenolate Mofetil for Prevention of Acute GVHD
ClinicalTrials.gov Identifier: NCT00506948 - Recruiting
Hematological Malignancies; Myelodysplastic Syndrome; Leukemia; Lymphoma
- Efficacy of Sirolimus-Based, Steroid Avoidance Immunosuppression African Americans
ClinicalTrials.gov Identifier: NCT00189202 - Recruiting
End Stage Renal Disease; Kidney Transplantation
- Steroid Withdrawal in Pediatric Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00023244 - Active, not recruiting
End-Stage Renal Disease
- Pediatric Kidney Transplant without Calcineurin Inhibitors
ClinicalTrials.gov Identifier: NCT00023231 - Active, not recruiting
End-Stage Renal Disease
- Tacrolimus and Sirolimus as Prophylaxis After Allogenic Non-Myeloablative Peripheral Blood Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00282282 - Recruiting
Graft Versus Host Disease; GVHD
- Study of the Safety and Efficacy of Conversion From a CNI to Sirolimus in Renally-Impaired Heart Transplant Recipients
ClinicalTrials.gov Identifier: NCT00369382 - Recruiting
Graft Rejection; Kidney Failure
- Sirolimus in Treating Patients With HIV-Related Kaposi's Sarcoma
ClinicalTrials.gov Identifier: NCT00450320 - Recruiting
Sarcoma
- Study Comparing Sirolimus/Prograf vs Sirolimus/CsA in High-Risk Renal Transplant Recipients
ClinicalTrials.gov Identifier: NCT00470665 - Completed
Renal Allograft Recipients
- Study Evaluating Sirolimus in Kidney Transplant Recipients.
ClinicalTrials.gov Identifier: NCT00167947 - Recruiting
Kidney Failure; Graft Vs Host Disease
- Comparison of Sirolimus to Tacrolimus for Long Term Therapy in Kidney Transplant With No Steroids
ClinicalTrials.gov Identifier: NCT00170053 - Recruiting
Kidney Diseases
- Study Evaluating Sirolimus in Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00195273 - Recruiting
Graft vs Host Disease; Kidney Transplantation
- Efficacy and Safety of Sirolimus for Treating Lymphangioleiomyomatosis (LAM)
ClinicalTrials.gov Identifier: NCT00414648 - Recruiting
Lymphangioleiomyomatosis
- Daclizumab and Sirolimus to Treat Uveitis
ClinicalTrials.gov Identifier: NCT00078689 - Active, not recruiting
Uveitis
- EUROPEAN TRIAL OF IMMUNOSUPPRESSION IN SPK Tx.
ClinicalTrials.gov Identifier: NCT00140543 - Active, not recruiting
Diabetes Mellitus, Type 1; Diabetic Nephropathy
- The Comparison of Tacrolimus and Sirolimus Immunosuppression Based Drug Regimens in Kidney Transplant Recipients
ClinicalTrials.gov Identifier: NCT00275535 - Recruiting
Kidney Diseases
- A Study of the Combination of Sirolimus and Sutent in Patients With Advanced Solid Tumors That Are Non-Curable With Standard Therapy
ClinicalTrials.gov Identifier: NCT00402415 - Recruiting
Tumors
- Sirolimus in Treating Patients With Metastatic or Unresectable Solid Tumors
ClinicalTrials.gov Identifier: NCT00368914 - Recruiting
Unspecified Adult Solid Tumor, Protocol Specific
- Combination Therapy to Prevent Kidney Transplant Rejection
ClinicalTrials.gov Identifier: NCT00078559 - Active, not recruiting
Kidney Transplantation
- Islet Cell Transplants for Diabetes
ClinicalTrials.gov Identifier: NCT00014911 - Active, not recruiting
Diabetes Mellitus, Insulin-Dependent
- Sirolimus in Treating Young Patients With Relapsed or Refractory Acute Leukemia or Non-Hodgkin's Lymphoma
ClinicalTrials.gov Identifier: NCT00068302 - Recruiting
recurrent childhood lymphoblastic lymphoma; recurrent childhood small noncleaved cell lymphoma; recurrent childhood large cell lymphoma; ...
- Gefitinib and Sirolimus in Treating Patients With Recurrent or Refractory Stage IIIB or Stage IV Non-Small Cell Lung Cancer
ClinicalTrials.gov Identifier: NCT00098462 - Recruiting
recurrent non-small cell lung cancer; stage IIIB non-small cell lung cancer; stage IV non-small cell lung cancer
- Study of a Long-Term Combination of Mycophenolate Mofetil and Sirolimus in Patients Who Received a Liver Transplant
ClinicalTrials.gov Identifier: NCT00118742 - Active, not recruiting
Liver Diseases; Liver Transplantation
- Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who are Undergoing Donor Stem Cell Transplant for Hematologic Cancer
ClinicalTrials.gov Identifier: NCT00105001 - Recruiting
childhood Hodgkin's lymphoma; childhood non-Hodgkin's lymphoma; Graft Versus Host Disease; hematopoietic and lymphoid cancer
- Influence of Sirolimus and MMF on Vascular Function and Markers of Cellular Function in Renal Transplant Recipients
ClinicalTrials.gov Identifier: NCT00204321 - Recruiting
Renal Transplantation
- Sirolimus Treatment in Patients With Autosomal Dominant Polycystic Kidney Disease: Renal Efficacy and Safety
ClinicalTrials.gov Identifier: NCT00491517 - Recruiting
Polycystic Kidney
- Antithymocyte Globulin and Sirolimus in Treating Patients With Relapsed Multiple Myeloma
ClinicalTrials.gov Identifier: NCT00317798 - Recruiting
Drug Toxicity; Multiple Myeloma and Plasma Cell Neoplasm
- Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular Degeneration
ClinicalTrials.gov Identifier: NCT00304954 - Recruiting
Macular Degeneration; Neovascularization
- GISSOC II: Sirolimus Eluting Stent Versus Bare Metal Stent in Chronic Total Coronary Occlusions
ClinicalTrials.gov Identifier: NCT00220558 - Recruiting
Coronary Artery Disease
- A Phase II Study of Rapamycin (Rapamune, Sirolimus) and Trastuzumab (Herceptin) for Patients With HER-2 Receptor Positive Metastatic Breast Cancer
ClinicalTrials.gov Identifier: NCT00411788 - Recruiting
Breast Cancer
- Polymorphism of the Cytochrome P450-System and the MDR-System in Renal Transplants Receiving the Immunosuppressive Drugs Tacrolimus, Sirolimus, Everolimus or Cyclosporine A
ClinicalTrials.gov Identifier: NCT00223054 - Recruiting
Renal Transplantation
- Sirolimus Before Surgery in Treating Patients With Advanced Localized Prostate Cancer
ClinicalTrials.gov Identifier: NCT00311623 - Recruiting
Prostate Cancer
- Sirolimus and Bevacizumab in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
ClinicalTrials.gov Identifier: NCT00467194 - Recruiting
Liver Cancer
- Trial of Efficacy and Safety of Sirolimus in Tuberous Sclerosis and LAM
ClinicalTrials.gov Identifier: NCT00490789 - Recruiting
Tuberous Sclerosis; Lymphangioleiomyomatosis
- Renal Allograft Recipients Study
ClinicalTrials.gov Identifier: NCT00038948 - Active, not recruiting
Renal Allograft Recipients
- Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia
ClinicalTrials.gov Identifier: NCT00319878 - Recruiting
Anemia, Aplastic
- Sirolimus in Treating Patients With Advanced Pancreatic Cancer
ClinicalTrials.gov Identifier: NCT00499486 - Recruiting
Pancreatic Cancer
- Bypass Surgery Versus Angioplasty Using Sirolimus-Eluting Stent in Patients With Left Main Coronary Artery Disease
ClinicalTrials.gov Identifier: NCT00422968 - Recruiting
Coronary Artery Disease
- A Study to Evaluate the Discontinuation Effect of Clopidogrel After Drug Eluting Stent Implantation in Non-Diabetic Patients
ClinicalTrials.gov Identifier: NCT00493779 - Recruiting
Non-Diabetic Subjects With One or More Sirolimus or Paclitaxel Drug-Eluting Stents
- Sirolimus in Preventing Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov Identifier: NCT00077480 - Recruiting
chronic myeloproliferative disorders; Graft Versus Host Disease; Leukemia; Lymphoma; myelodysplastic and myeloproliferative diseases; ...
- A Study of the mTOR Inhibitor Rapamycin (Rapamune, Sirolimus) in Combination With Abraxane in Advanced Solid Cancers
ClinicalTrials.gov Identifier: NCT00337376 - Recruiting
Advanced Solid Cancers
- Zotarolimus-Versus Sirolimus-Versus PacliTaxel-Eluting Stent for Acute Myocardial Infarction Patients
ClinicalTrials.gov Identifier: NCT00422565 - Recruiting
Myocardial Infarction
- Erlotinib and Sirolimus for the Treatment of Metastatic Renal Cell Carcinoma
ClinicalTrials.gov Identifier: NCT00353301 - Recruiting
Advanced Renal Cell Carcinoma
- Pilot Trial of Treatment of Poor-Prognosis Iga Nephropathy With Low Exposure to Sirolimus.
ClinicalTrials.gov Identifier: NCT00396721 - Recruiting
Glomerulonephritis, IGA; Nephropathy, IGA; IGA Nephropathy
- AIRSAC Trial - Comparison of a Tacrolimus/Sirolimus/Prednisone Regimen Versus Tacrolimus/Azathioprine/Prednisone Immunosuppressive Regimen in Lung Transplantation
ClinicalTrials.gov Identifier: NCT00321906 - Recruiting
Delayed Graft Function; Graft Rejection
- Sirolimus-Based Immunosuppression in Liver Transplantation for High Risk Hepatocellular Carcinoma Patients
ClinicalTrials.gov Identifier: NCT00328770 - Recruiting
Liver Graft Recipients With High Risk Hepato-Cellular Carcinoma
- Intra-Individual Comparison of Sirolimus and Paclitaxel Coated Stent (FRE-RACE Study)
ClinicalTrials.gov Identifier: NCT00130546 - Recruiting
Coronary Artery Disease
- Sirolimus in Autoimmune Lymphoproliferative Syndrome: A Pilot Series
ClinicalTrials.gov Identifier: NCT00392951 - Recruiting
Autoimmune Lymphoproliferative Syndrome (ALPS)
- Evaluating the Use of Thymoglobulin, Sirolimus, and Donor Bone Marrow with Kidney Transplantation Patients
ClinicalTrials.gov Identifier: NCT00062712 - Completed
Kidney Transplantation
- Sirolimus-Eluting vs Zotarolimus-Eluting Stents for Chronic Total Coronary Occlusions
ClinicalTrials.gov Identifier: NCT00428454 - Recruiting
Coronary Artery Disease; Coronary Disease; Coronary Stenosis
- Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD)
ClinicalTrials.gov Identifier: NCT00406393 - Recruiting
Leukemia, Myelocytic, Acute; Leukemia, Lymphocytic, Acute; Leukemia, Myeloid, Chronic; Myelodysplastic Syndromes
- Sirolimus as Treatment of Steroid-Refractory or Steroid-Dependent Chronic Graft-Versus-Host Disease
ClinicalTrials.gov Identifier: NCT00388362 - Recruiting
Graft vs Host Disease
- Kidney Transplants in People with HIV Infection
ClinicalTrials.gov Identifier: NCT00023478 - Active, not recruiting
HIV Infections; End-Stage Renal Disease
- Tacrolimus and Methotrexate With or Without Sirolimus in Preventing Graft-Versus-Host Disease in Young Patients Undergoing Donor Stem Cell Transplant for Acute Lymphoblastic Leukemia in Complete Remission
ClinicalTrials.gov Identifier: NCT00382109 - Recruiting
Graft Versus Host Disease; Leukemia
- Pediatric Kidney Transplant Study of Sirolimus, Mycophenolate Mofetil, and Corticosteroids vs Calcineurin Inhibitor Based Immunosuppression
ClinicalTrials.gov Identifier: NCT00555373 - Not yet recruiting
Renal Transplant
- Treating Multiple Sclerosis With Sirolimus, an Immune System Suppressor
ClinicalTrials.gov Identifier: NCT00095329 - Completed
Multiple Sclerosis
- Zotarolimus-Eluting Stent Versus Sirolimus-Eluting Stent Versus PacliTaxel-Eluting Stent for Coronary Lesions
ClinicalTrials.gov Identifier: NCT00418067 - Recruiting
Coronary Artery Disease
- Sirolimus to Prevent GVHD after Stem Cell Transplant for Blood Cancers
ClinicalTrials.gov Identifier: NCT00074490 - Recruiting
Hematologic Neoplasms; Neural Tube Defects; Myeloproliferative Disorders
- Sirolimus for Focal Segmental Glomerulosclerosis
ClinicalTrials.gov Identifier: NCT00040508 - Completed
Focal Glomerulosclerosis
- Sirolimus- and Paclitaxel-Eluting Stents for Small Vessels
ClinicalTrials.gov Identifier: NCT00146575 - Completed
Coronary Disease
- Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are Receiving a Bone Marrow Transplant
ClinicalTrials.gov Identifier: NCT00002790 - Active, not recruiting
Chronic Myelogenous Leukemia; Graft Versus Host Disease; childhood acute lymphocytic leukemia; Myelodysplastic Syndrome; Chronic Lymphocytic Leukemia; ...
- Improving the Results of Bone Marrow Transplantation for Patients with Severe Congenital Anemias
ClinicalTrials.gov Identifier: NCT00061568 - Recruiting
Congenital Hemolytic Anemia; Diamond-Blackfan Anemia
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