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Tenofovir |
PMPA; TDF; Tenofovir Disoproxil Fumarate; Viread |
Tenofovir Systematic (IUPAC) name 1-(6-aminopurin-9-yl) propan-2-yloxymethylphosphonic acid Identifiers CAS number 147127-20-6 ATC code J05AF07 PubChem 464205 DrugBank APRD01248 Chemical data Formula C9H14N5O4P Mol. weight 287.213 g/mol Pharmacokinetic data Bioavailability 25% Protein binding < 1% Metabolism ? Half life 17 hours Excretion Renal Therapeutic considerations Pregnancy cat. B (U.S.) Legal status ℞-only (U.S.), POM ( ...
Wikipedia - [full article]
Tenofovir Clinical Trials
- Comparison of Elvucitabine/Efavirenz/Tenofovir Versus Lamivudine/Efavirenz/Tenofovir in HIV-1 Infected, Treatment Naive Subjects
ClinicalTrials.gov Identifier: NCT00350272 - Active, not recruiting
HIV Infections
- Extended Safety Study of Tenofovir Disoproxil Fumarate (TDF) Among HIV-1 Negative Men
ClinicalTrials.gov Identifier: NCT00131677 - Active, not recruiting
HIV Infection
- A 96 Week Study to Compare Tenofovir Versus Tenofovir Plus Emtricitabine for the Treatment of Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00507507 - Recruiting
Chronic Hepatitis B
- The Safety of Tenofovir Disoproxil Fumarate Taken with Other Anti-HIV Drugs to Treat HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00007436 - Active, not recruiting
HIV Infections
- A Study to Compare Tenofovir Versus Hepsera (Adefovir) for the Treatment of HBeAg Negative Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00117676 - Active, not recruiting
Chronic Hepatitis B
- A Study to Compare Tenofovir versus Hepsera (adefovir) for the Treatment of Hepatitis Be Antigen (HBeAg) Positive Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00116805 - Active, not recruiting
Chronic Hepatitis B
- Tenofovir Disoproxil Fumarate in HIV-Infected Patients Who Have Not Had Success with Other Anti-HIV Drug Combinations
ClinicalTrials.gov Identifier: NCT00011089 - Active, not recruiting
HIV Infections
- Study of Treatment of Antiretroviral-Naive, HIV-1-Infected Patients Comparing Tenofovir Disoproxil Fumarate Administered in Combination with Lamivudine and Efavirenz Vs. Stavudine, Lamivudine and Efavirenz.
ClinicalTrials.gov Identifier: NCT00158821 - Active, not recruiting
HIV-1
- Tenofovir Disoproxil Fumarate (DF)/Emtricitabine/Efavirenz Versus Combivir/Efavirenz in Antiretroviral-Naive HIV-1 Infected Subjects
ClinicalTrials.gov Identifier: NCT00112047 - Active, not recruiting
HIV Infections
- A 48 week study looking at the effectiveness of giving saquinavir/ritonavir, twice daily plus emtricitabine/tenofovir, once daily compared to giving lopinavir/ritonavir twice daily plus emtricitabine/tenofovir once daily in HIV-1 patients not previously t
ClinicalTrials.gov Identifier: NCT00105079 - Active, not recruiting
HIV Infections
- Bangkok Tenofovir Study
ClinicalTrials.gov Identifier: NCT00119106 - Recruiting
HIV Infections
- Effect of Tenofovir Disoproxil Fumarate on Lipid Levels in HIV Infected Adults on Stable Anti-HIV Drug Therapy
ClinicalTrials.gov Identifier: NCT00109603 - Active, not recruiting
HIV Infections; Dyslipidemia; Hyperlipidemia; Hypercholesterolemia; Hypertriglyceridemia
- Safety and Blood Levels of Tenofovir Disoproxil Fumarate in HIV Infected Pregnant Women and Their Babies
ClinicalTrials.gov Identifier: NCT00120471 - Recruiting
HIV Infections
- Efavirenz Or Atazanazir/Ritonavir Given with Emtricitabine/Tenofovir Disoproxil Fumarate Or Abacavir/Lamivudine in HIV Infected Treatment-Naive Adults
ClinicalTrials.gov Identifier: NCT00118898 - Active, not recruiting
HIV Infections
- Safety of Tenofovir Disoproxil Fumarate (TDF) in HIV Infected Pregnant Women and Their Infants
ClinicalTrials.gov Identifier: NCT00076791 - Recruiting
HIV Infections
- Tenofovir Alone Versus Tenofovir With Emtricitabine to Treat Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00524173 - Recruiting
Chronic Hepatitis B e Antigen Positive; Chronic Hepatitis B e Antigen Negative
- Immediate Versus Deferred Start of Anti-HIV Therapy in HIV Infected Adults Being Treated for Tuberculosis
ClinicalTrials.gov Identifier: NCT00108862 - Recruiting
HIV Infections; Tuberculosis
- Efficacy of Tenofovir-Emtricitabine and Efavirenz in HIV Infected Patients with Tuberculosis
ClinicalTrials.gov Identifier: NCT00115609 - Recruiting
HIV Infections; Tuberculosis
- Effectiveness of Nucleoside Supplementation and Substituting Tenofovir Disoproxil Fumarate for Other Drugs in Anti-HIV Regimens in Reversing Fat Loss in HIV Infected Adults
ClinicalTrials.gov Identifier: NCT00119379 - Recruiting
HIV Infections; Lipodystrophy; Metabolic Diseases; Nutrition Disorders
- Abacavir/Lamivudine Versus Emtricitabine/Tenofovir Both In Combination With Lopinavir/Ritonavir For The Treatment Of HIV
ClinicalTrials.gov Identifier: NCT00244712 - Active, not recruiting
HIV Infections
- Safety and Effectiveness of Tenofovir Disoproxil Fumarate (Tenofovir DF) Plus Other Anti-HIV Drugs in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002450 - Completed
HIV Infections
- Viral Dynamics and Pharmacokinetics of Abacavir and Tenofovir
ClinicalTrials.gov Identifier: NCT00214890 - Recruiting
HIV Infections
- Tenofovir DF (Disoproxil Fumarate) in Combination with Emtricitabine in HIV-1 Patients
ClinicalTrials.gov Identifier: NCT00106379 - Completed
HIV Infections
- A Two Year Study of the Clinical Efficacy of the Combination of Emtricitabine, Tenofovir, and Nevirapine.
ClinicalTrials.gov Identifier: NCT00344461 - Recruiting
HIV
- Pharmacokinetic Study of the Vaginal Microbicide Agent 1% Tenofovir Gel
ClinicalTrials.gov Identifier: NCT00561496 - Recruiting
HIV Infections
- The Safety and Effectiveness of PMPA Prodrug in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002396 - Active, not recruiting
HIV Infections
- Tenofovir in HIV/HBV Coinfection
ClinicalTrials.gov Identifier: NCT00192595 - Active, not recruiting
HIV Infection; Hepatitis B Coinfection
- Tenofovir/Emtricitabine for PMTCT in Africa and Asia (ANRS 12109 TEmAA)
ClinicalTrials.gov Identifier: NCT00334256 - Recruiting
HIV Infection; Pregnancy
- Comparing the Safety, Effectiveness, and Tolerability of Three Anti-HIV Drug Regimens for Treatment-Naive Patients
ClinicalTrials.gov Identifier: NCT00050895 - Active, not recruiting
HIV Infections
- A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
ClinicalTrials.gov Identifier: NCT00036452 - Active, not recruiting
HIV Infections
- A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy
ClinicalTrials.gov Identifier: NCT00102206 - Active, not recruiting
HIV Infections
- Anti-HIV Drugs During Pregnancy
ClinicalTrials.gov Identifier: NCT00042289 - Active, not recruiting
HIV Infections
- RMS-Reyataz Study in Treatment in Naive Subjects to Compare the Efficacy and Safety Between Boosted Reyataz and Kaletra When in Combination With Fixed Dose Truvada
ClinicalTrials.gov Identifier: NCT00272779 - Active, not recruiting
HIV
- Evolution of L74V or K65R Mutations in VIremic Subjects on Tenofovir Disoproxil Fumarate (TDF) or Abacavir (ABC) (EVITA)
ClinicalTrials.gov Identifier: NCT00312169 - Recruiting
HIV Infections
- Once-Daily PI/NNRTI Therapy Combinations for Treatment Naive, HIV Infected Patients in Resource-limited Conditions
ClinicalTrials.gov Identifier: NCT00084136 - Active, not recruiting
HIV Infections
- Safety and Acceptability of a Vaginal Microbicide
ClinicalTrials.gov Identifier: NCT00111943 - Active, not recruiting
HIV Infections; Hepatitis B, Chronic
- Antiretroviral Switch From Didanosine to Tenofovir in HIV/HCV Co-Infected Patients
ClinicalTrials.gov Identifier: NCT00358696 - Recruiting
HIV
- Emtricitabine/Tenofovir Disoproxil Fumarate for HIV Prevention in Men
ClinicalTrials.gov Identifier: NCT00458393 - Recruiting
HIV Infections
- Safety and Efficacy of Tenofovir DF in HIV-1 Infected Adolescents Failing Their Current Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00352053 - Recruiting
HIV Infections
- Nevirapine or Atazanavir/Ritonavir Given With Emtricitabine/Tenofovir DF in HIV-1-Infected Treatment Naive Adults
ClinicalTrials.gov Identifier: NCT00389207 - Recruiting
HIV Infections
- Efficacy of Tenofovir and Emtricitabine in ARV-Naive Patients With HIV/HBV co-Infection
ClinicalTrials.gov Identifier: NCT00476463 - Recruiting
Hepatitis B Virus; HIV Infections
- Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children (Ages 2- <12)
ClinicalTrials.gov Identifier: NCT00528957 - Recruiting
HIV Infections
- Using Drug Levels and Drug Resistance Testing to Select Effective Anti-HIV Drug Combinations in Patients With Drug-resistant HIV
ClinicalTrials.gov Identifier: NCT00027339 - Active, not recruiting
HIV Infections
- Efficacy and Tolerance of Peg-Interferon Alpha 2a Added to Tenofovir and Emtricitabine in AgHBe Positive HBV-HIV co-Infected Patients
ClinicalTrials.gov Identifier: NCT00391638 - Recruiting
Hepatitis B; HIV Infections
- Tenofovir Disoproxil Fumarate to Treat Pediatric HIV
ClinicalTrials.gov Identifier: NCT00024986 - Completed
HIV Infection
- Phase III Open Label Atazanavir (BMS-232632) in Combination with Ritonavir or Saquinavir, and Lopinavir/Ritonavir, each with Tenofovir and a Nucleoside in Subjects with HIV
ClinicalTrials.gov Identifier: NCT00035932 - Active, not recruiting
HIV Infections
- Study of Anti-HIV Therapy Intensification
ClinicalTrials.gov Identifier: NCT00034086 - Active, not recruiting
HIV Infections
- Study Comparing Tenofovir Disoproxil Fumarate (TDF), Emtricitabine/TDF, & Entecavir in the Treatment of Chronic HBV in Subjects w/Decompensated Liver Disease.
ClinicalTrials.gov Identifier: NCT00298363 - Recruiting
Chronic Hepatitis B
- Testing the Safety of Tenofovir Vaginal Gel in Pregnant Women Who Are Having a C-Section
ClinicalTrials.gov Identifier: NCT00572273 - Not yet recruiting
Pregnancy
- Early Intensification of Antiretroviral Therapy Including Enfuvirtide in HIV-1-Related Progressive Multifocal Leucoencephalopathy
ClinicalTrials.gov Identifier: NCT00120367 - Active, not recruiting
Leukoencephalopathy, Progressive Multifocal; HIV Infections
- FOTO: Five Consecutive Days on Treatment With Efavirenz, Tenofovir, and Emtricitabine Followed by Two Days Off Treatment Versus Continuous Treatment
ClinicalTrials.gov Identifier: NCT00414635 - Recruiting
HIV Infections
- A Study to Evaluate the Pharmacokinetic Profile (How the Body Absorbs, Distributes, Metabolizes, and Eliminates a Drug), of TMC125 Plus Tenofovir/Emtricitabine Once Daily With or Without Darunavir/r Once Daily in Antiretroviral (ARV) Nave HIV-1 Patients (
ClinicalTrials.gov Identifier: NCT00534352 - Recruiting
HIV-1 Infection
- Simple Once Daily Triple Regimen Including Tenofovir, Emtricitabine and Efavirenz in HIV-1 Infected Patients (ANRS 1207)
ClinicalTrials.gov Identifier: NCT00158457 - Completed
HIV Infection
- The STEAL Study
ClinicalTrials.gov Identifier: NCT00192634 - Recruiting
HIV
- Nine Month Course of Anti-HIV Medications for People Recently Infected with HIV
ClinicalTrials.gov Identifier: NCT00090779 - Recruiting
HIV Infections
- Zidovudine / Lamivudine + Nevirapine Twice Daily, Versus Tenofovir + Lamivudine + Nevirapine Once Daily in ARV-Naive Patients
ClinicalTrials.gov Identifier: NCT00199979 - Recruiting
Hiv Infection With Antiretroviral Therapy Indication; CD4 Below 350/µL or Below 15%
- Entecavir Plus Tenofovir Combination Therapy Versus Entecavir Monotherapy in Naive Subjects With Chronic Hepatitis B
ClinicalTrials.gov Identifier: NCT00410072 - Recruiting
Hepatitis B, Chronic
- A Comparison of Adefovir and Tenofovir for the Treatment of Lamivudine-Resistant Hepatitis B Virus in People With HIV
ClinicalTrials.gov Identifier: NCT00033163 - Completed
HIV Infections; Hepatitis B
- NNRTI- Versus PI-Containing Regimens for HIV Infected Women After They Have Taken Nevirapine to Prevent Mother-To-Child Transmission of HIV
ClinicalTrials.gov Identifier: NCT00089505 - Recruiting
HIV Infections
- Comparison of Three Anti-HIV Regimens to Prevent Nevirapine Resistance in Women who Take Nevirapine During Pregnancy
ClinicalTrials.gov Identifier: NCT00099632 - Recruiting
HIV Infections
- Study of Lopinavir, Ritonavir, Tenofovir and Emtricitabine in HIV-Infected Antiretroviral Naïve Subjects
ClinicalTrials.gov Identifier: NCT00043966 - Completed
HIV Infections
- Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery
ClinicalTrials.gov Identifier: NCT00540605 - Not yet recruiting
HIV Infections
- Study of Tenofovir Disoproxil Fumarate (TDF) for Prevention of HIV
ClinicalTrials.gov Identifier: NCT00122486 - Completed
HIV Infections
- A Compassionate Use Study of Tenofovir Disoproxil Fumarate as Treatment for HIV Infection
ClinicalTrials.gov Identifier: NCT00002453 - Completed
HIV Infections
- Effectiveness of ABT-378/Ritonavir Plus Lamivudine Plus Efavirenz Plus Tenofovir DF in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00038220 - Completed
HIV Infections
- Pharmacokinetics of Emtricitabine/Tenofovir + Efavirenz in HIV-Infected Patients With Tuberculosis
ClinicalTrials.gov Identifier: NCT00474435 - Not yet recruiting
Tuberculosis; HIV Infections
- Pharmacokinetic and Efficacy of SQV/r 1500/100 Plus Tenofovir/Emtricitabine 300/200 mg
ClinicalTrials.gov Identifier: NCT00476983 - Not yet recruiting
Saquinavir/Ritonavir BID or Lopinavir/Ritonavir BID
- Tenofovir Disoproxil Fumarate (TDF) in HIV-1 Patients Who Have Never Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00016588 - Completed
HIV Infections
- Virological and Clinical Anti-HBV Efficacy of Tenofovir and Emtricitabine in Patients with HIV/HBV Co-Infection
ClinicalTrials.gov Identifier: NCT00127959 - Completed
HIV-1 infection; Hepatitis B virus infection
- TMC278-TiDP6-C209: A Clinical Trial in Treatment naïve HIV-1 Patients Comparing TMC278 to Efavirenz in Combination With Tenofovir + Emtricitabine.
ClinicalTrials.gov Identifier: NCT00540449 - Not yet recruiting
HIV-1; HIV Infections; Human Immunodeficiency Virus Type 1
- Botswana Tenofovir Oral HIV Prophylaxis Trial
ClinicalTrials.gov Identifier: NCT00111150 - Terminated
HIV Infection
- A Study Exploring an Induction-Maintenance Kaletra-Based Therapy Versus a Sustiva-Based Regimen in Previously Non-Treated, HIV-1/HCV Co-Infected Subjects
ClinicalTrials.gov Identifier: NCT00121017 - Not yet recruiting
HIV Infection; Hepatitis C
- To Determine if There Are Pharmacokinetic Interactions at Plasma or Intracellular Level Between Nucleosides and Tenofovir.
ClinicalTrials.gov Identifier: NCT00335192 - Completed
HIV
- Efficacy and Safety of Tenofovir DF/Atazanavir Enhanced with Low Dose of Ritonavir in HIV-Infected Patients with Multiple Treatment Failures
ClinicalTrials.gov Identifier: NCT00122577 - Terminated
HIV Infections
- Phase II Comparator Study of Substitution of Tenofovir or Abacavir Receiving Thymidine Analogue as Part of HAART.
ClinicalTrials.gov Identifier: NCT00270556 - Completed
HIV
- A Study to Probe the Safety and Durability of Tenofovir and a Cell Cycle Agent to Maintain Viral Suppression
ClinicalTrials.gov Identifier: NCT00344981 - Completed
HIV Infections; AIDS
- Drug Interaction Study With Famotidine, Atazanavir, and Atazanavir/Ritonavir/Tenofovir
ClinicalTrials.gov Identifier: NCT00365339 - Completed
HIV Infections
- Immuno-Virological Efficacy of Combination With Trizivir +Tenofovir in Multiresistant HIV Patients
ClinicalTrials.gov Identifier: NCT00356616 - Completed
HIV Infections
- Study of Tenofovir Disoproxil Fumarate (TDF) for Prevention of HIV
ClinicalTrials.gov Identifier: NCT00122512 - Terminated
Human Immunodeficiency Virus
- Study Comparing Reducing the Dose of Stavudine Versus Switching to Tenofovir in HIV-Infected Patients Receiving Antiretroviral Therapy
ClinicalTrials.gov Identifier: NCT00312832 - Completed
HIV Infections; Lipoatrophy
- Daily Tenofovir DF to Prevent HIV Infection Among Sex Workers in Cambodia
ClinicalTrials.gov Identifier: NCT00078182 - Terminated
HIV Infections; HIV Seronegativity
- A Study of PMPA in HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002180 - Completed
HIV Infections
- Safety and Acceptability of the Anti-Microbe Vaginal Gel, PMPA Gel
ClinicalTrials.gov Identifier: NCT00028132 - Completed
HIV Infections
- A Comparison of Two Drug Combinations Used in HIV-Infected Patients Who Never Have Taken Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00005573 - Completed
HIV Infections
- Safety and Effectiveness of Adding PMPA Prodrug to an Anti-HIV Drug Combination to Treat HIV-Infected Patients
ClinicalTrials.gov Identifier: NCT00002415 - Completed
HIV Infections
- Effect of Tenofovir DF on Bone Metabolism in Children
ClinicalTrials.gov Identifier: NCT00088309 - Completed
HIV Infections
- Dual Versus Triple Protease Inhibitor Combinations, Including Ritonavir, in HIV Infected People
ClinicalTrials.gov Identifier: NCT00028366 - Completed
HIV Infections
- Effects of Anti-HIV Therapy on Treatment for Hepatitis C in HCV/HIV Infected Adults
ClinicalTrials.gov Identifier: NCT00100581 - Completed
HIV Infections; Hepatitis C
- Preventing Sexual Transmission of HIV With Anti-HIV Drugs
ClinicalTrials.gov Identifier: NCT00074581 - Completed
HIV Infections; HIV Seronegativity
- Comparing Standard-Dose Versus Adjusted-Dose Lopinavir/Ritonavir Therapy in HIV-Infected Persons with Drug Resistance
ClinicalTrials.gov Identifier: NCT00046033 - Completed
HIV Infections
- Effect of an Enfuvirtide-based Anti-HIV Drug Regimen on Latent HIV Reservoirs in Treatment Naive Adults
ClinicalTrials.gov Identifier: NCT00051831 - Suspended
HIV Infections
- Three Month Course of Anti-HIV Medications for People Recently Infected with HIV
ClinicalTrials.gov Identifier: NCT00087464 - Terminated
HIV Infections
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