Article: Tranylcypromine

Tranylcypromine
Systematic (IUPAC) name
2-phenylcyclopropan-1-amine
Identifiers
CAS number	155-09-9
ATC code	N06AF04
PubChem	5530
DrugBank	APRD00645
Chemical data
Formula	C9H11N
Mol. weight	133.19
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	4.4 - 8 hours
Excretion	Urine Feces
Therapeutic considerations
Pregnancy cat.	C (United States
Legal status	Unscheduled
Routes	Oral

Tranylcypromine (sold under the brand name Parnate®) is a monoamine oxidase inhibitor (MAOI) used as an antidepressant drug.

Pharmacology

Tranylcypromine is a non-hydrazine, irreversible monoamine oxidase inhibitor, and has a rapid onset of action.

The antidepressant activity of tranylcypromine is thought to be due to the fact that it increases the concentration of epinephrine, norepinephrine, and serotonin throughout the nervous system. This is achieved through the inhibition of monoamine oxidase.

Indications

Tranylcypromine is used for the treatment of major depressive episodes, without melancholia.

Contraindications

As with other MAOIs, those who are taking tranylcypromine must adhere to rigid dietary specifications in order to prevent complications.

Overdose

Symptoms of tranylcypromine overdose may include: insomnia, restlessness, anxiety, agitation, mental confusion, hypotension, dizziness, weakness, somnolence, hypertension, and headache.

Foods high in tyramine can precipitate hypertensive crisis. Tyramine can be found in cheeses, wine, and certain meats. MAOIs inhibit tyramine breakdown, thus dietary intake should be avoided.