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Modafinil |
Provigil |
Modafinil Systematic (IUPAC) name 2-benzhydrylsulfinylethanamide Identifiers CAS number 68693-11-8 ATC code N06BA07 PubChem 4236 DrugBank APRD00534 Chemical data Formula C15H15NO2S Mol. weight 273.351 g/mol Pharmacokinetic data Bioavailability ? Protein binding 60% Metabolism Hepatic, including CYP3A4 and other pathways Half life 23-215 hours Excretion Urine (as metabolites) Therapeutic considerations Pregnancy cat. C Legal status Schedul ...
Wikipedia - [full article]
Modafinil Clinical Trials
- Randomised Placebo-Controlled Trial of Modafinil for Methamphetamine Dependence
ClinicalTrials.gov Identifier: NCT00123370 - Active, not recruiting
Amphetamine Dependence
- Modafinil to Treat Fatigue in Post-Polio Syndrome
ClinicalTrials.gov Identifier: NCT00067496 - Active, not recruiting
Postpoliomyelitis Syndrome
- Randomised Placebo-Controlled Trial of Modafinil for Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00123383 - Active, not recruiting
Cocaine Dependence
- The Effects of MODafinil on Waking Function and on Sleep in Individuals with Promary Insomnia
ClinicalTrials.gov Identifier: NCT00124384 - Recruiting
Primary Insomnia
- Modafinil for the Treatment of Cocaine Dependence - 1
ClinicalTrials.gov Identifier: NCT00100100 - Active, not recruiting
Cocaine-Related Disorders
- Modafinil in Treating Fatigue in Patients Receiving Chemotherapy for Cancer
ClinicalTrials.gov Identifier: NCT00042848 - Active, not recruiting
Fatigue; unspecified adult solid tumor, protocol specific
- Effects of Modafinil on Brain Function in Patients with Schizophrenia
ClinicalTrials.gov Identifier: NCT00057707 - Recruiting
Schizophrenia; Schizoaffective Disorder
- Modafinil Treatment for Cocaine-Dependent Individuals - 1
ClinicalTrials.gov Identifier: NCT00129285 - Recruiting
Cocaine-Related Disorders
- Evaluation of Modafinil as a Cocaine Treatment Medication and Interactions with Cocaine - 1
ClinicalTrials.gov Identifier: NCT00033046 - Active, not recruiting
Cocaine-Related Disorders; Drug Administration Schedule; Infusions, Intravenous
- Modafinil in Treating Fatigue and Behavioral Change in Patients With Primary Brain Cancer
ClinicalTrials.gov Identifier: NCT00052286 - Active, not recruiting
adult brain tumor; Fatigue; cognitive/functional effects
- Assessment of Interactions Between Intravenous Methamphetamine and Modafinil - 1
ClinicalTrials.gov Identifier: NCT00265278 - Active, not recruiting
Amphetamine-Related Disorders
- Modafinil for Fatigue in HIV/AIDS
ClinicalTrials.gov Identifier: NCT00118378 - Recruiting
HIV Infections; Fatigue
- Modafinil in Treating Fatigue in Patients With Cancer
ClinicalTrials.gov Identifier: NCT00112515 - Active, not recruiting
Depression; cognitive/functional effects; Quality of Life; Fatigue; unspecified adult solid tumor, protocol specific
- Modafinil in Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00142402 - Active, not recruiting
Multiple Sclerosis
- Modafinil-Alcohol Interactions in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00305292 - Active, not recruiting
Alcohol
- Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy
ClinicalTrials.gov Identifier: NCT00107796 - Completed
Narcolepsy
- Modafinil to Reduce Persistent Fatigue in Patients Following Treatment for Cancer
ClinicalTrials.gov Identifier: NCT00178373 - Active, not recruiting
Cancer; Fatigue; Chemotherapy
- Modafinil for Treatment of Cognitive Dysfunction in Schizophrenia
ClinicalTrials.gov Identifier: NCT00423943 - Recruiting
Schizophrenia; Schizoaffective Disorder
- Modafinil Combined With Cognitive Behavior Therapy to Treat Cocaine Addiction - 1
ClinicalTrials.gov Identifier: NCT00218387 - Recruiting
Cocaine Dependence
- Memory and Attention Problems in Lupus: New Treatment Trial With Modafinil
ClinicalTrials.gov Identifier: NCT00297284 - Recruiting
Systemic Lupus Erythematosus
- Modafinil Augmentation Therapy for Excessive Daytime Sleepiness and Negative Symptoms in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00546403 - Recruiting
Schizophrenia
- Safety and Tolerability of Modafinil for Methamphetmaine Dependence
ClinicalTrials.gov Identifier: NCT00569374 - Recruiting
Methamphetamine Dependence
- Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents
ClinicalTrials.gov Identifier: NCT00258479 - Recruiting
Tobacco Use Disorder
- Ph2 Modafinil Meth - 1
ClinicalTrials.gov Identifier: NCT00520286 - Not yet recruiting
Methamphetamine Dependence
- Modafinil as an Adjunctive on Cognitive Functioning in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00314639 - Recruiting
Schizophrenia and Schizophrenia Spectrum Psychosis
- Community-Based Modafinil Treatment of Women With Cocaine Dependence and HIV-High Risk Behavior
ClinicalTrials.gov Identifier: NCT00368290 - Recruiting
Cocaine Dependence
- A Placebo-Controlled Double-Blind Combined Treatment of Modafinil and CBT for Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00344565 - Recruiting
Cocaine Dependence
- Comparison of Modafinil and Methylphenidate in Treatment of Excessive Daytime Sleepiness in Patients With Parkinson's Disease
ClinicalTrials.gov Identifier: NCT00393562 - Recruiting
Parkinson's Disease
- Study of PROVIGIL ® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome
ClinicalTrials.gov Identifier: NCT00107809 - Completed
Sleep Apnea, Obstructive
- Effects of Modafinil on the Tolerability and Efficacy for Cognition of Atypical Antipsychotic Drugs in Patients With Schizophrenia or Schizoaffective Disorder
ClinicalTrials.gov Identifier: NCT00373672 - Recruiting
Schizophrenia; Schizoaffective Disorder
- Study to Evaluate the Efficacy of Modafinil Treatment in Patients With Attention Deficit Hyperactivity Disorder (ADHD) Who Are Responders to Modafinil Treatment
ClinicalTrials.gov Identifier: NCT00343811 - Completed
Attention Deficit Hyperactivity Disorder
- Modafinil vs Placebo for the Treatment of Methamphetamine Dependence
ClinicalTrials.gov Identifier: NCT00469508 - Recruiting
Methamphetamine Dependence
- Trial of Effects of Oral Xyrem and Zolpidem on Sleep-Disordered Breathing in Obstructive Sleep Apnea Patients
ClinicalTrials.gov Identifier: NCT00086281 - Active, not recruiting
Obstructive Sleep Apnea Syndrome
- PROVIGIL® (Modafinil) Treatment in Children and Adolescents With Excessive Sleepiness Associated With Narcolepsy or Obstructive Sleep Apnea/Hypopnea Syndrome
ClinicalTrials.gov Identifier: NCT00107848 - Completed
Narcolepsy; Sleep Apnea, Obstructive
- A Pilot Trial of Modafinil for Treatment of Methamphetamine Dependence
ClinicalTrials.gov Identifier: NCT00538655 - Not yet recruiting
Methamphetamine Addiction
- Pharmacotherapy Dosing Regimen in Cocaine Dependent Individuals - 12
ClinicalTrials.gov Identifier: NCT00218062 - Recruiting
Cocaine Abuse; Cocaine-Related Disorders
- Pharmacotherapy Dosing Regimen in Cocaine and Opiate Dependent Individuals - 8
ClinicalTrials.gov Identifier: NCT00218036 - Recruiting
Cocaine Abuse; Cocaine-Related Disorders
- Modafinil in Opioid Induced Sedation
ClinicalTrials.gov Identifier: NCT00267332 - Terminated
Cancer; Pain
- Modafinil, Sleep, and Cognition in Cocaine Dependence
ClinicalTrials.gov Identifier: NCT00582491 - Recruiting
Cocaine Dependence; Substance-Induced Sleep Disorder; Substance-Induced Cognitive Disorder
- Provigil (Modafinil) Study by Taiwan Biotech Co.
ClinicalTrials.gov Identifier: NCT00174174 - Completed
Narcolepsy; Cataplexy; Sleep Disorders; Hypersomnolence; Excessive Sleepiness
- Modafinil and Naltrexone for the Treatment of Cocaine and Alcohol Dependence - 3
ClinicalTrials.gov Identifier: NCT00142818 - Recruiting
Alcohol-Related Disorders; Alcoholism; Cocaine Abuse, Cocaine-Related Disorders; alcohol & drug use
- Study to Assess Satisfaction With Modafinil Treatment in Children and Adolescents With ADHD
ClinicalTrials.gov Identifier: NCT00228540 - Completed
ADHD
- A Placebo-Controlled Trial of Modafinil (Provigil) Added to Clozapine in Patients With Schizophrenia
ClinicalTrials.gov Identifier: NCT00573417 - Completed
Schizophrenia
- Evaluate the Safety and Efficacy of Modafinil in Children and Adolescents With ADHD
ClinicalTrials.gov Identifier: NCT00214981 - Completed
Attention Deficit/Hyperactivity Disorder; ADHD
- Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD
ClinicalTrials.gov Identifier: NCT00315276 - Completed
Attention Deficit Hyperactivity Disorder; ADHD
- Trial Comparing Effects of Xyrem taken Orally and Modafinil with Placebo in Treating Daytime Sleepiness in Narcolepsy
ClinicalTrials.gov Identifier: NCT00066170 - Completed
Narcolepsy
- Modafinil for Atypical Depression
ClinicalTrials.gov Identifier: NCT00215176 - Completed
Atypical Depression
- Neuromodulation and Language Acquisition (Project stage Ia)
ClinicalTrials.gov Identifier: NCT00102284 - Terminated
Healthy
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