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Lamotrigine |
Lamictal |
Lamotrigine Systematic (IUPAC) name 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine Identifiers CAS number 84057-84-1 ATC code N03AX09 PubChem 3878 DrugBank APRD00570 Chemical data Formula C9H7Cl2N5 Mol. weight 256.091 g/mol Pharmacokinetic data Bioavailability 98% Protein binding 55% Metabolism Hepatic Half life 24-34 hours (healthy adults) Excretion Renal Therapeutic considerations Pregnancy cat. C (USA) Legal status N/A(USA); POM (UK) R ...
Wikipedia - [full article]
Lamotrigine Clinical Trials
- Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
ClinicalTrials.gov Identifier: NCT00068445 - Active, not recruiting
Quality of Life; neurotoxicity; Pain; unspecified adult solid tumor, protocol specific
- Lamotrigine Alone Compared to Lamotrigine Plus Antidepressant for the Treatment of Bipolar II Depression
ClinicalTrials.gov Identifier: NCT00475137 - Not yet recruiting
Bipolar II Depression
- A Multicenter, Double-Blind, Study on the Efficacy and Safety of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With a Recent Manic or Mixed Episode
ClinicalTrials.gov Identifier: NCT00277212 - Recruiting
Bipolar I Disorder With a Recent Manic or Mixed Episode
- A Study To Investigate The Antidepressant Effect Of Lamotrigine In Patients With Bipolar Disorder Using Lithium
ClinicalTrials.gov Identifier: NCT00224510 - Active, not recruiting
Bipolar Depression
- Lamotrigine in the Treatment of Binge Eating Disorder Associated With Obesity
ClinicalTrials.gov Identifier: NCT00277641 - Recruiting
Binge Eating Disorder Associated With Obesity
- Combination Therapy for the Treatment of Bipolar Disorders
ClinicalTrials.gov Identifier: NCT00063362 - Active, not recruiting
Bipolar Disorder
- Patient, Provider, and Healthcare System Factors Associated with in Suboptimal Prescribing for Older Patients with Epilepsy
ClinicalTrials.gov Identifier: NCT00144001 - Active, not recruiting
Epilepsy
- Acute Treatment of Bipolar II Depression
ClinicalTrials.gov Identifier: NCT00074776 - Active, not recruiting
Bipolar Depression
- Developmental Effects On Children Of Women Who Take Antiepileptic Drugs During Pregnancy
ClinicalTrials.gov Identifier: NCT00021866 - Active, not recruiting
Epilepsy; Seizure; Cognition Disorders
- Evaluation of Lamotrigine on Neuropathic Facial Pain Using fMRI
ClinicalTrials.gov Identifier: NCT00243152 - Recruiting
Facial Neuropathy
- Study of Hormonal Sideeffects in Patients Taking Levetiracetam, Carbamazepine or Lamotrigine for Epilepsy
ClinicalTrials.gov Identifier: NCT00460070 - Recruiting
Epilepsy
- Lamotrigine Versus Levetiracetam in the Initial Monotherapy of Epilepsy
ClinicalTrials.gov Identifier: NCT00242606 - Recruiting
Epilepsy
- Lamotrigine Extended-Release in Elderly Patients With Epilepsy
ClinicalTrials.gov Identifier: NCT00516139 - Recruiting
Epilepsy
- Divalproex vs. Lamotrigine for Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00451542 - Active, not recruiting
Bipolar Disorder
- Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated Patients
ClinicalTrials.gov Identifier: NCT00223262 - Active, not recruiting
Memory Impairment Due to Corticosteroid Use.; Hypomania Due to Corticosteroid Use.; Hippocampal Atrophy Due to Corticosteroid.
- Epilepsy Hormone Study
ClinicalTrials.gov Identifier: NCT00137709 - Recruiting
Epilepsy
- A Study in Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized Seizures
ClinicalTrials.gov Identifier: NCT00292461 - Recruiting
Epilepsy
- An Evaluation of BW430C (Lamotrigine) Versus Placebo in the Prevention of Mood Episodes in Bipolar I Disorder Patients
ClinicalTrials.gov Identifier: NCT00550407 - Recruiting
Bipolar Disorder
- An Open-Label Trial Measuring Satisfaction and Convenience of Two Formulations of Lamotrigine in Subjects With a Mood Disorder
ClinicalTrials.gov Identifier: NCT00579982 - Recruiting
Mood Disorder
- Six Month Trial of Lamotrigine Vs. Sodium Valproate for Treatment of Mixed Mania
ClinicalTrials.gov Identifier: NCT00206778 - Recruiting
Mixed Mania Bipolar Disorder
- Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7
ClinicalTrials.gov Identifier: NCT00015106 - Completed
Cocaine-Related Disorders
- Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age
ClinicalTrials.gov Identifier: NCT00238576 - Recruiting
Bipolar Disorder
- Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression
ClinicalTrials.gov Identifier: NCT00305578 - Recruiting
Bipolar Depression
- Study of Efficacy of Lamotrigine in Therapy of Bronchial Asthma
ClinicalTrials.gov Identifier: NCT00153244 - Completed
Bronchial Asthma
- Lamotrigine Monotherapy in Pediatric Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00176228 - Recruiting
Bipolar Disorder
- A Study to Evaluate LAMICTAL Extended-release Therapy in Patients with Primary Generalized Tonic Clonic Seizures
ClinicalTrials.gov Identifier: NCT00104416 - Active, not recruiting
Tonic-Clonic Seizures; Epilepsy
- Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study
ClinicalTrials.gov Identifier: NCT00088452 - Active, not recruiting
Childhood Absence Epilepsy; Petit Mal Epilepsy; Epilepsy; Seizures
- Lamotrigine for the Treatment of Mania in Youth Ages 6-17 With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00181844 - Recruiting
Bipolar Disorder; Mania
- Lamotrigine Add-on Therapy for Bipolar Disorder and Cocaine Dependency
ClinicalTrials.gov Identifier: NCT00280293 - Recruiting
Bipolar Disorder; Cocaine Dependence
- A Randomised Controlled Trial of Neuroprotection With Lamotrigine in Secondary Progressive Multiple Sclerosis
ClinicalTrials.gov Identifier: NCT00257855 - Recruiting
Secondary Progressive Multiple Sclerosis
- A Clinical Evaluation of BW430C (Lamotrigine) in Bipolar I Disorder - Long-Term Extension of Study SCA104779 -
ClinicalTrials.gov Identifier: NCT00566020 - Not yet recruiting
Bipolar Disorder
- Observational Study of Lamotrigine
ClinicalTrials.gov Identifier: NCT00299793 - Completed
Epilepsy
- Venlafaxine Augmentation
ClinicalTrials.gov Identifier: NCT00253266 - Not yet recruiting
Treatment Resistant Depression
- Bioequivalence And Lack Of Food Effects Of 300mg Lamotrigine XR
ClinicalTrials.gov Identifier: NCT00412191 - Completed
Epilepsy
- Antiglutamate Anticonvulsants in the Treatment of Alcohol Withdrawal Syndrome
ClinicalTrials.gov Identifier: NCT00241995 - Completed
Topiramate; Lamotrigine; Memnatine; Diazepam; Placebo
- Venlafaxine Versus Lamotrigine in the Treatment of Bipolar I/II Depression
ClinicalTrials.gov Identifier: NCT00188643 - Completed
Bipolar Disorder
- Study to Compare Two Formulations of Lamotrigine in Healthy Subjects
ClinicalTrials.gov Identifier: NCT00410371 - Completed
Healthy Volunteers
- Prophylactic Effect of Lamotrigine Compared With Lithium in Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00226135 - Completed
Bipolar Disorder
- Bioequivalence And Effect Of Food And Water On Lamotrigine in Healthy Volunteers
ClinicalTrials.gov Identifier: NCT00449774 - Completed
Healthy Volunteers
- An Open-Label Extension Study Of Lamotrigine In Subjects With Bipolar Disorder
ClinicalTrials.gov Identifier: NCT00360126 - Completed
Bipolar Disorder Type I and Type II
- CSP #428 - Treatment of Seizures in the Elderly Population
ClinicalTrials.gov Identifier: NCT00007670 - Completed
seizures in the elderly
- Drug-Drug Interaction Study of Aripiprazole and Lamotrigine in Patients With Bipolar Type I Disorder
ClinicalTrials.gov Identifier: NCT00321516 - Completed
Bipolar Disorder
- Lamotrigine in Treatment Resistant Depression in Adolescents
ClinicalTrials.gov Identifier: NCT00284791 - Suspended
Adolescent Depression
- Lamotrigine and Oral Contraceptives
ClinicalTrials.gov Identifier: NCT00266149 - Terminated
Epilepsy
- Neurobiology of Opioid Dependence: 1 - 1
ClinicalTrials.gov Identifier: NCT00000192 - Completed
Opioid-Related Disorders
- Open-Label Evaluation Of LAMICTAL (Lamotrigine) For The Treatment Of Absence Seizures
ClinicalTrials.gov Identifier: NCT00144872 - Completed
Typical Absence Epilepsy
- Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
ClinicalTrials.gov Identifier: NCT00012558 - Completed
Mood Disorders; Affective Disorders, Psychotic; Bipolar Disorder; Cyclothymic Disorder
Resources
- Lamictal (Drug Digest)
- Lamotrigine (Drug Digest)
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