Article: Ifosfamide

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Ifosfamide
Systematic (IUPAC) name
3-(2-chloroethyl)-2
-[(2-chloroethyl)amino]tetrahydro
-2H-1,3,2-oxazaphosphorine 2-oxide
Identifiers
CAS number ?
ATC code ??
PubChem ?
DrugBank ?
Chemical data
Formula C7H15Cl2N2O2P
Mol. weight 261.1
Pharmacokinetic data
Bioavailability 100%
Metabolism Hepatic
Half life 60-80% in 72 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

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Legal status

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Routes intravenously


Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous, and is given as a treatment for a variety of cancers, including:

  • Testicular cancer
  • Breast cancer
  • Lymphoma (Non-Hodgkin)
  • Soft tissue sarcoma
  • Osteogenic sarcoma
  • Lung cancer
  • Cervical cancer
  • Ovarian cancer
  • Bone cancer

Ifosfamide is often used in conjunction with mesna to avoid internal bleeding in the patient.

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