RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells and slow the growth of non-Hodgkin's lymphoma. It is not yet known whether combining more than one chemotherapy drug with interferon alfa is more effective than chemotherapy alone in treating patients with low-grade non-Hodgkin's lymphoma.

PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without interferon alfa in treating patients with low-grade non-Hodgkin's lymphoma.

OBJECTIVES: I. Compare the remission induction rates and toxicity of chlorambucil plus dexamethasone with or without idarubicin in patients with stage II-IV low grade non-Hodgkin's lymphoma.

II. Assess the additional value of a period of consolidation/maintenance treatment utilizing low dose interferon alfa or standard dose interferon alfa versus no further treatment in relationship to the duration of event-free survival in these patients.

PROTOCOL OUTLINE: This is a randomized, open label, controlled, multicenter study. Patients are randomized into one of two arms for induction chemotherapy.

Arm I: Patients receive oral chlorambucil three times daily for 3 consecutive days, oral idarubicin daily for 3 consecutive days, and oral dexamethasone twice daily for 5 consecutive days every 21 days.

Arm II: Patients receive oral chlorambucil three times daily for 3 consecutive days and oral dexamethasone twice daily for 5 consecutive days every 21 days.

Treatment for both arms continues for up to 6 courses in the absence of disease progression or unacceptable toxicity.

After 6 courses of chemotherapy, patients are reassessed. If they have achieved maximal complete response or good partial response, patients are randomized into one of three arms.

Arm I: Patients receive no further treatment until disease progresses.

Arm II: Patients receive low dose interferon alfa subcutaneously three times per week for a maximum of 3 years in the absence of disease progression.

Arm III: Patients receive standard dose interferon alfa subcutaneously three times a week for a maximum of 3 years in the absence of disease progression.

Patients are followed every 8-12 weeks for 3 years.

PROJECTED ACCRUAL: There will be 200 patients accrued into this study with approximately 150 patients entering the second phase of this study.

Ages Eligible for Study:  15 Years   -   70 Years

Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

• Histologically confirmed B cell low grade non-Hodgkin's lymphoma; Stage II, III or IV
• Measurable disease
• No chronic lymphatic leukemia, prolymphocytic leukemia and hairy cell leukemia, angioimmunoblastic lymphadenopathy, mycosis fungoides, Sezary's syndrome and T-zone lymphoma, plasmacytoma, T cell lymphomas, or centroblastic lymphoma
• No CNS disease

[A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology.]

--Prior/Concurrent Therapy--

• Biologic therapy: Not specified
• Chemotherapy: No prior chemotherapy; No other concurrent chemotherapy
• Endocrine therapy: Not specified
• Radiotherapy: No prior extensive radiotherapy for any malignant disease; Prior radiotherapy for localized disease that subsequently relapses permitted
• Surgery: Not specified

--Patient Characteristics--

• Age: 15 to 70
• Performance status: ECOG 0-2
• Life expectancy: Not specified
• Hematopoietic: Granulocyte count at least 2,000/mm3; Platelet count at least 150,000/mm3
• Hepatic: Bilirubin no greater than 1.96 mg/dL AST/ALT no greater than 2 times upper limit of normal
• Renal: Creatinine no greater than 1.65 mg/dL OR Creatinine clearance no greater than 40 mL/min
• Cardiovascular: No history of myocardial infarction in the past 12 months; No severe or uncontrolled cardiac failure
• Other: No history of malignant disease except basal cell carcinoma or carcinoma in situ of the cervix; No active peptic ulceration, significant dyspepsia, or history of hematemesis or melena; No concurrent medical or psychological condition that may preclude study participation; Not pregnant; Effective contraception required of all fertile patients