. The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

Inclusion Criteria:

• Smoke at least 10 cigarettes per day for the previous 6 months
• Expired CO > 9 ppm
• Motivated to quit smoking
• Able to read and write English
• Willing to complete required study assessments

Exclusion Criteria:

• Uncontrolled hypertension (systolic >180mm Hg or diastolic >110mm Hg)
• History of bipolar disorder or psychosis
• Myocardial infarction or other serious cardiac problem in the previous 4 weeks
• History of diagnosed anorexia and/or bulimia
• Diagnosis of Alcohol Dependence in the previous 6 months by participant self-report or drinking 6 or more drinks on six or more days a week
• History of seizure and/or serious head injury involving loss of consciousness
• Use of contraindicated medications (MAO inhibitors, bupropion, lithium, anticonvulsants, antipsychotics)
• Currently pregnant or breast-feeding
• Unwilling to use effective contraception during the treatment phase
• More than one participant from the same household
• Allergic reactions to 3 or more classes of drugs