Saquinavir hard-gel capsule 27 (Invirase) was the first PI approved by the FDA, in December 1995. A carboxamide derivative specifically designed to inhibit HIV proteinase and prevent post-translational formation of viral proteins, saquinavir is a potent inhibitor of HIV-1 and HIV-2 proteinases without prior metabolic activation. At 12 nM concentration, saquinavir has a 50% inhibition of normal HIV, and at 11 nM it has a 50% inhibition of ZDV-resistant HIV.

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... SAQUINAVIR (Invirase®, Fortovase®) is an antiviral drug called a protease inhibitor. Saquinavir is used to treat human immunodeficiency virus (HIV) infection. Saquinavir may reduce the amount of HIV in the blood and increase the number of CD4 cells (T-cells) in the blood. Saquinavir is used in combination with other drugs to treat the HIV virus. You may still develop other infections or conditions associated with HIV. Saquinavir will not cure or prevent HIV infection or AIDS. Generic saquinavir capsules are not yet available. ...
Drug Digest - more...

Saquinavir Systematic (IUPAC) name N-[1-benzyl-2-hydroxy-3- [3-(t ...
Wikipedia - [full article]

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